Our Funded Research Projects

Updated April 2021

Title Principal Investigator / Supervisor Program Project Start Date Project End Date Sort ascending Total $ Awarded
IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes Principal Investigator: NING, Shuoyan

Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer
Intramural Research Grant Program $270,352
Modulation of biofilm formation, virulence, and antimicrobial resistance by Staphylococcus aureus during platelet storage Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: SAD, Subash, MAH, Thien-Fah
Intramural Research Grant Program $323,253
Fc receptors and IVIg in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: CSERTI-GAZDEICH, Christine, LIN, Yulia, CALLUM, Jeannie, SHOLZBERG, Michelle, NI, Heyu
Intramural Research Grant Program $432,000
New solution for cord blood unit preservation Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: KAUSHAL, Richa
Graduate Fellowship Program $116,500
Anti-GPIb mediated thrombocytopenia: Implications for IVIG and other therapies Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: LAZARUS, Alan, BRANCH, Donald
Intramural Research Grant Program $412,010
Identification of mechanisms leading to antibody independent RBC hemolysis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: FRIAS BOLIGAN, Kayluz
Postdoctoral Fellowship Program $150,000
Small molecule drug development of phagocytosis inhibitors Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P.
Intramural Research Grant Program $428,468
New platform for targeted gene editing of hematopoietic stem cells for cellular
therapy
Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MAGANTI, Harinad
Postdoctoral Fellowship Program $150,000
Plasma transfusion or plasma protein product infusion in a murine model of trauma Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward
Intramural Research Grant Program $257,415
Donor factors and product quality Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: YAZDANBAKHSH, Mahsa
Graduate Fellowship Program $52,000
Mechanisms of anti-αIIb mediated miscarriage in fetal and neonatal alloimmune thrombocytopenia Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: CHEN, Zi Yan
Graduate Fellowship Program $52,000
Deformability based cell sorting enabling quality control of stored red blood cells Principal Investigator: MA, Hongshen

Co-Investigator(s) / Trainee: ISLAMZADA, EMEL
Graduate Fellowship Program $112,333
Perioperative Transfusion Threshold : A Population-Based Observational Study Principal Investigator: FERGUSSON, Dean

Co-Investigator(s) / Trainee: VERRET, Michael
Graduate Fellowship Program $52,000
Development of a drug to replace IVIg, and ADCC as cause for unexplained hemolysis post-transfusion Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: ALMIZRAQ, Ruqayyah
Postdoctoral Fellowship Program $150,000
Reducing IVIG usage by developing novel prophylaxis therapies against FNAIT Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: PASMAN, Yfke
Postdoctoral Fellowship Program $150,000
Support of HLA laboratory directors in-training for rotations in specialized laboratories Principal Investigator: WAGNER, Eric

Co-Investigator(s) / Trainee: KEOWN, Paul, LIWSKI, Robert, CAMPBELL, Patricia, BERKA, Noureddine, WANG, Jinguo, MOSTAFA, Ahmed, CHEE-LOONG, Saw, RICHARD, Lucie, CHARGÉ, Sophie, DHARSEE, Fatima
BloodTechNet Award Program $8,490
Demonstration of genetic blood group transition in patients undergoing ABO-mismatched hematopoietic stem cell transplantation by peripheral blood quantitative polymerase chain reaction targeting the ABO locus Principal Investigator: SHIH, Andrew

Co-Investigator(s) / Trainee: LAZO-LANGER, Alejandro, D'SOUZA, David, CALLUM, Jeannie, LEUNG, Eric, CHIN-YEE, Ian
Blood Efficiency Accelerator Program $15,990
Transcriptome analyses of Staphylococcus aureus grown in platelet concentrates with focus on virulence Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: DA SILVA PAREDES, Carina
Graduate Fellowship Program $52,000
A machine learning based framework to analyze blood product transactional data for reducing discards Principal Investigator: CHENG, Calvino

Co-Investigator(s) / Trainee: ABIDI, Syed Sibte Raza, BLAKE, John, LIWSKI, Robert, QUINN, Jason, ABUSHAREKH, Ashraf, ABIDI, Samina, XIANG, Richard
Blood Efficiency Accelerator Program $29,950
Blood and stem cell donation for men who have sex with men in Canada: A toolkit for healthcare professionals Principal Investigator: FINGRUT, Warren

Co-Investigator(s) / Trainee: GOLDMAN, Mindy, SHIH, Andrew, ELMOAZZEN, Heidi, ALLAN, David, PETRASZKO, Tanya, YAN, Matthew, COUPAL, Dylan, SEGALL, Romy, CHOWDHURY, Fuad, CAI, Helen, KUMAR, Shamini Vijaya, TRAADE, Daniel, ROSENFELD, Aaron, KAVEH, Farrokhi
BloodTechNet Award Program $20,000
Evaluating unintentional warming of glycerolized red cell concentrates Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: CLARKE, Gwen, TURNER, Tracy, OLAFSON, Carly, MYKHAILOVA, Olga
Blood Efficiency Accelerator Program $25,000
Anti-RBC monoclonal antibodies as a replacement for IVIg and anti-D in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: BRANCH, Donald, DUNN, Shannon
Intramural Research Grant Program $400,000
Measurement of heavy metals in donor blood in Canada Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: SERRANO, Katherine, LEVIN, Elena, MURPHY, Michael, BARAKAUSKAS, Vilte, HADJESFAMDOARI, Narges, ARRIETA, Angele, RICHARDSON-SANCHEZ, Tomas
Blood Efficiency Accelerator Program $29,971
A study to understand C1 esterase inhibitor distribution and patterns of use in Canada Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: HEDDLE, Nancy, KEITH, Paul, WASERMAN, SUSAN, WEBERT, Kathryn, NING, Shuoyan, SHIH, Andrew, MORRISON, Doug, YAN, Matthew
Blood Efficiency Accelerator Program $29,859
Are cervical cancer brachytherapy outcomes associated with pre-brachytherapy hemoglobin values and transfusion practice? An observational study comparing two academic centres. Principal Investigator: SOLH, Ziad

Co-Investigator(s) / Trainee: LAZO-LANGER, Alejandro, D'SOUZA, David, CALLUM, Jeannie, LEUNG, Eric, CHIN-YEE, Ian
Blood Efficiency Accelerator Program $27,670
PREMISE: Point-of-care hemoglobin accuracy and transfusion outcomes in non-cardiac surgery Principal Investigator: MARTEL, Guillaume

Co-Investigator(s) / Trainee: TINMOUTH, Alan, FERGUSSON, Dean, MCISAAC, Daniel, SHAW, Julie, RAMSAY, Tim, PRESSEAU, Justin, WHERRETT, Christopher, CARRIER, François-Martin, SEELY, Andrew, BRYSON, Gregory
Intramural Research Grant Program $392,974
Development of porcine equivalent RCC and plasma units for translatable ex vivo organ perfusion research Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: FREED, Darren
Intramural Research Grant Program $121,834
Revisiting the universal donor: Does exposure to O blood products affect patient outcomes? Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: ACKER, Jason, BUCKSTEIN, Rena, CALLUM, Jeannie, COOK, Richard, HEDDLE, Nancy, SOLH, Ziad, WEBERT, Kathryn, BARTY, Rebecca, LEBER, Brian, LALIT, Saini
Intramural Research Grant Program $378,365
New cryosolution for stem cell-based therapeutics Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: BEN, Robert, HARPER, Marie-Ellen, CHAKRABORTY, Nilay
Intramural Research Grant Program $180,000
Assessing the impact of donor manufacturing characteristics on survival of transfused red blood cells Principal Investigator: TINMOUTH, Alan

Co-Investigator(s) / Trainee: ACKER, Jason, FERGUSSON, Dean, CHASSÉ, Michaël
Intramural Research Grant Program $90,935
Development of a small molecule cocktail for the expansion of cord blood stem cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: BLAKE, John, AUDET, Julie
Intramural Research Grant Program $237,600
Enabling next generation hematopoietic-based therapeutics and manufacturing Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MCCOMB, Scott, JEZIERSKI, Anna, MAGALHAES, Ana, IQBAL, Umer
Intramural Research Grant Program $300,000
Evaluating the role of donor characteristics and blood component manufacturing on the quality of red cell concentrates Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: BRANCH, Donald, CLARKE, Gwen, NAHIRNIAK, Susan
Intramural Research Grant Program $398,383
Translating novel clotting factor X function to threat thrombosis Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: MACVICAR, Brian, SHEFFIELD, William
Intramural Research Grant Program $369,052
Synthesis and live cell imaging of ice recrystallization inhibitors in red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: MCMUNN, Leah
Graduate Fellowship Program $52,000
Investigating a new class of small molecule ice recrystallization inhibitors for red blood cell cryopreservation Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: AMPAW, Anna
Graduate Fellowship Program $112,333
University of Toronto QUEST Research Program Principal Investigator: CALLUM, Jeannie

Co-Investigator(s) / Trainee:
Transfusion Medicine Research Program Support Award $1,137,400
Blood product demand forecast modeling using clinical predictors Principal Investigator: DOWN, Douglas

Co-Investigator(s) / Trainee: BLAKE, John , TRIFUNOV, Rick, COURTNEY, Thomas, HEDDLE, Nancy, CHIANG, Fei, LI, Na
Blood Efficiency Accelerator Program $30,000
Evaluation and improvement of cold stored platelets Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: ZHAO, Hanqi (Wayne)
Graduate Fellowship Program $112,333
Replacement of IVIg by small molecule inhibitors of phagocytosis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: LORIAMINI, Melika
Graduate Fellowship Program $52,000
McMaster Centre for Transfusion Research Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee:
Transfusion Medicine Research Program Support Award $1,150,000
The mechanism of action of monoclonal antibody blends in the potential replacement of anti-D in HDFN Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: CRUZ-LEAL, Yoelys
Postdoctoral Fellowship Program $150,000
Pediatric Transfusion Camp Principal Investigator: LIEBERMAN, Lani

Co-Investigator(s) / Trainee: LIN, Yulia, CALLUM, Jeannie, WALSH, Catherine, CHARGÉ, Sophie, WILLIAMS, Suzanne, FARONI, David, MEMA, Briseida, LACROIX, Jacque, LAU, Wendy, ROBITAILLE, Nancy, FINAN, Emer, HUME, Heather, HASPEL, Richard, ATKINSON, Adelle, SCOLNIK, Dennis
BloodTechNet Award Program $10,500
Novel mechanisms of platelet aggregation: Roles of non-classical beta-3 integrin ligands and fibronectin in thrombosis and hemostasis Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $398,871
Canadians’ attitudes and opinions regarding cardiac donation after cardiocirculatory death: A mixed-methods study Principal Investigator: BALL, Ian

Co-Investigator(s) / Trainee: WEISS, Matt D'ARAGON, Fred PARSONS LEIGH, Jenna HONARMAND, Kimia BASMAJI, John SIBBALD, Robert
Kenneth J. Fyke Award Program $95,929
Expanding treatment options for inflammatory bowel disease: A novel mechanism of antibody-based immunotherapy Principal Investigator: SLY, Laura

Co-Investigator(s) / Trainee: HORWITZ, Marc, BRESSLER, Brian, RASSEKH, Rod, TURVEY, Stuart
Canadian Blood Services-CIHR Partnership Operating Grant Program $408,541
Fetal and neonatal alloimmune thrombocytopenia: novel mechanisms and therapeutic approaches Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $471,393
Virtual transfusions competency assessment Principal Investigator: VAN VLIET, Paula

Co-Investigator(s) / Trainee: DEYDEY, Kim, WESOLOWSKI, Mike
BloodTechNet Award Program $32,795
Donor characteristics and the quality of red cell concentrates Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: MYKHAILOVA, Olga
Postdoctoral Fellowship Program $150,000
Awareness and understanding of apheresis plasma donation and effectiveness of alternative donor screening questions for diverse gbMSM and trans populations Principal Investigator: GAHAGAN, Jacqueline

Co-Investigator(s) / Trainee: HAW, Jennie, LACHOWSKY, Nathan, DRYDEN, OmiSoore, MANNING, Eli, FOSTER, Terrie, O'BRIEN, Sheila, HACHETTE, Todd, MULLOWNEY, Mike
MSM Plasma Program $200,500