Our Funded Research Projects

Updated April 2024

Title Principal Investigator / Supervisor Program Project Start Date Sort ascending Project End Date Total $ Awarded
Development of a small molecule-based stem and progenitor expansion protocol to accelerate engraftment after cord blood transplantation Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MANESIA, Javed
Postdoctoral Fellowship Program 101200.0
A multifaceted intervention to optimize red blood cell transfusion practice in two provinces Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle
Intramural Research Grant Program 332942.0
Data sharing with CBMTG registry Principal Investigator: ALLAN, David

Co-Investigator(s) / Trainee: PAULSON, Kristjan
Small Project Funding Program 15000.0
Plasma versus plasma protein concentrate transfusion for coagulopathic control Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: NI, Heyu
Intramural Research Grant Program 224417.0
Improving pathogen inactivation: the dengue virus-induced platelet proteome Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: TEGEGN, Tseday Zewdu
Graduate Fellowship Program 104000.0
Human monoclonal CD44 antibodies as potential IVIg replacements Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu
Intramural Research Grant Program 336000.0
ROTEM-guided transfusion protocols - impact on the manufacturer Principal Investigator: TRUDEAU, Jacqueline

Co-Investigator(s) / Trainee: PETRASZKO, Tanya, LI, Cecilia
Small Project Funding Program 15000.0
Neonatal outcomes after transfusion of ABO non-identical blood (Neo-ABO) Principal Investigator: SOLH, Ziad

Co-Investigator(s) / Trainee: HEDDLE, Nancy, COOK, Richard J., FUSCH, Christoph
Small Project Funding Program 14988.7
Pre-transfusion furosemide for TACO Principal Investigator: SKEATE, Robert

Co-Investigator(s) / Trainee: CALLUM, Jeannie
Small Project Funding Program 15000.0
National evaluation of platelet transport bags to reduce wastage Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee: CALLUM, Jeannie, LIN, Yulia, LIEBERMAN, Lani, PENDERGRAST, Jacob, CSERTI-GAZDEWICH, Christine
Small Project Funding Program 9740.0
Use of red blood cell antigen genotyping to assess RhD diversity in sickle cell disease patients Principal Investigator: SHIH, Andrew

Co-Investigator(s) / Trainee: BERARDI, Philip, CLARKE, Gwen, HANNON, Judith, HEDDLE, Nancy, VERHOVSEK, Madeleine
Small Project Funding Program 15000.0
Social media for knowledge translation and education 3 (SoMe-KTE3): Transfusion, thrombosis, and hemostasis Principal Investigator: SHIH, Andrew

Co-Investigator(s) / Trainee: CHAN, Teresa, DE WIT, Kristin, BHAGIRATH, Vinai, YEH, Calvin, CASTELLUCI, Lana, ELAHIE, Allahna, HEDDLE, Nancy, THOMA, Brent
BloodTechNet Award Program 30000.0
Podcast for FNAIT and ICTMG red cell specifications for hemoglobinopathies guidelines Principal Investigator: SHEHATA, Nadine

Co-Investigator(s) / Trainee:
BloodTechNet Award Program 6200.0
The Stem Cell Club: educating medical and nursing students to develop professional skills Principal Investigator: FINGRUT, Warren

Co-Investigator(s) / Trainee:
BloodTechNet Award Program 24458.0
Small molecule ice recrystallization inhibitors as cryo-additives for red blood cell cryopreservation Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: POISSON, Jessica
Graduate Fellowship Program 82000.0
Red cell genotyping using buccal swab DNA Principal Investigator: BERARDI, Philip

Co-Investigator(s) / Trainee: GOLDMAN, Mindy R., HANNON, Judith, CLARKE, Gwen, LIWSKI, Robert
Small Project Funding Program 15000.0
Platelet desialylation: novel mechanism of platelet clearance and immune tolerance Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: LI, June
Graduate Fellowship Program 104000.0
Incidence of intracranial hemorrhage in pediatric oncology patients Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee:
Small Project Funding Program 15000.0
Dengue virus replication by anucleate cells: impact on pathogen reduction efficacy Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: FELGENHAUER, Ulrike
Graduate Fellowship Program 52000.0
Role of blood component manufacturing on microvesicle-induced transfusion-related immune modulation Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: HOLOVATI, Jelena, BRANCH, Donald, ZHANG, Haibo
Intramural Research Grant Program 250660.0
Monoclonal antibodies with anti-D-like activity in the amelioration of murine immune thrombocytopenia (ITP) Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SEMPLE, John W., NI, Heyu
Intramural Research Grant Program 400000.0
Organ donation in Canada: Engaging with stakeholders and proposing solutions to current legal and ethical challenges Principal Investigator: GRUBEN, Vanessa

Co-Investigator(s) / Trainee:
James Kreppner Fellowship Program 150000.0
DNA aptamers for detection of red blood cells destined for rapid post-transfusion clearance Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: DONKOR, David
Postdoctoral Fellowship Program 150000.0
Recombinant Fc multimers to replace IVIG Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: LEWIS, Bonnie
Graduate Fellowship Program 104000.0
Study of the mechanisms implicated in platelets microparticle internalization by blood cells Principal Investigator: BOILARD, Eric

Co-Investigator(s) / Trainee: MARCOUX, Genevieve
Graduate Fellowship Program 104000.0
Transfusion-Related Acute Lung Injury and delayed TRALI: a prospective study in critically ill children Principal Investigator: EMERIAUD, Guillaume

Co-Investigator(s) / Trainee: DU PONT-THIBIDEAU, Genevieve, FONTELA, Patricia S. , GAUVIN, France, GILFOYLE, Elaine, HUTCHISON, James S., LACROIX, Jacques, MENON, Kusum, ROBITAILLE, Nancy, TINMOUTH, Alan T., TROTTIER, Helen
Canadian Blood Services-CIHR Partnership Operating Grant Program 477651.0
Examining the relationship between repeated blood donations in female donors on maternal/neonatal outcomes: a cohort study Principal Investigator: TINMOUTH, Alan

Co-Investigator(s) / Trainee: CHASSE, Michael, FERGUSSON, Dean A., GOLDMAN, Mindy R., O'BRIEN, Sheila F., SPRAGUE, Ann, van WALRAVEN, Carl, WALKER, Mark C., WILSON, Kumanan
Canadian Blood Services-CIHR Partnership Operating Grant Program 135657.0
Aneurysmal SubArachnoid Hemorrhage - Red blood cell transfusion And outcome (SAHaRA): a pilot randomized controlled trial Principal Investigator: ENGLISH, Shane

Co-Investigator(s) / Trainee: McINTYRE, Lauralyn A. , ALGIRD, Almunder , BOUTIN, Amélie , CHASSE, Michael , DOWLATSHAHI, Dariush , FERGUSSON, Dean A. , GRIESDALE, Donald , KRAMER, Andreas H. , LAUZIER, François , LUM, Cheemun , MARSHALL, Shawn C. , PAGLIARELLO, Giuseppe , SINCLAIR, John , TINMOUTH, Alan T. , TURGEON, Alexis F.
Canadian Blood Services-CIHR Partnership Operating Grant Program 157172.0
Defining disease mechanisms in Immune Thrombocytopenia (ITP) and their association with clinical outcomes Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: COOK, Richard J., NAZY, Ishac
Canadian Blood Services-CIHR Partnership Operating Grant Program 317469.0
Identification of host cellular immune mechanisms responsible for the initiation and/or modulation of Transfusion Related Acute Lung Injury (TRALI) Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: KUEBLER, Wolfgang M.
Canadian Blood Services-CIHR Partnership Operating Grant Program 398982.0
Myocardial Ischemia and Transfusion. The MINT rollover trial Principal Investigator: HEBERT, Paul

Co-Investigator(s) / Trainee: CARSON, Jeffrey L., DEVEREAUX, Philip J., EIKELBOOM, John W., FERGUSSON, Dean A., GOODMAN, Shaun G. , MCALISTER, Finlay A. , TINMOUTH, Alan T.
Canadian Blood Services-CIHR Partnership Operating Grant Program 140210.0
Polymer-based manufacturing tolerogenic miRNA-based therapeutics Principal Investigator: SCOTT, Mark

Co-Investigator(s) / Trainee: HORWITZ, Marc S.
Canadian Blood Services-CIHR Partnership Operating Grant Program 491125.0
Prospective observational study of organ deceased donor management in 3 ICUs - a pilot study (the DONATE pilot study) Principal Investigator: MEADE, Maureen

Co-Investigator(s) / Trainee: D'ARAGON, Frederick, RIBIC, Christine, SHARPE, Michael, BALL, Ian, WILLIAMSON, David, DHANANI, Sonny, HANNA, Steven
Kenneth J. Fyke Award Program 89555.1
Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: TONG, Tik Nga (Cindy)
Graduate Fellowship Program 52000.0
Understanding the factors that influence bacterial proliferation and biofilm formation in platelet concentrates Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: LOZA CORREA, Maria
Postdoctoral Fellowship Program 151800.0
Understanding IVIg mechanism(s) of action in alleviating immune platelet destruction and thrombocytopenia Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: KAPUR, Ricky
Postdoctoral Fellowship Program 106200.0
Transfusion options in coagulopathy: Efficacy in controlling bleeding Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: QADRI, Syed
Postdoctoral Fellowship Program 151800.0
Code sepsis: defining and translating optimal resuscitation and care for children with septic shock Principal Investigator: PARKER, Melissa

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership New Investigator Program 300000.0
Mechanism of anti-D-like antibody-mediated amelioration of immune thrombocytopenia (ITP) Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: YU, Xiaojie (Ben)
Postdoctoral Fellowship Program 106200.0
Defining the components of transfusable plasma that reduce bleeding Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward, NI, Heyu
Intramural Research Grant Program 218230.0
Mechanisms of antibody-independent transfusion-related acute lung injury (TRALI) Principal Investigator: KUEBLER, Wolfgang

Co-Investigator(s) / Trainee: SEMPLE, John W.
Canadian Blood Services-CIHR Partnership Operating Grant Program 328712.0
Understanding transcriptional and epigenetic control by Gfi1b towards the development of a therapy for sickle cell disease Principal Investigator: TRUDEL, Marie

Co-Investigator(s) / Trainee: MOROY, Tarik
Canadian Blood Services-CIHR Partnership Operating Grant Program 453132.0
Release, delivery and cell programming effects of platelet microparticles and microRNAs Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: BOILARD, Eric
Canadian Blood Services-CIHR Partnership Operating Grant Program 427422.0
Short and long-term clinical effects of blood donor characteristics in transfusion recipients Principal Investigator: FERGUSSON, Dean

Co-Investigator(s) / Trainee: ACKER, Jason P., CHASSÉ, Michael, ENGLISH, Shane, FORSTER, Alan, KNOLL, Greg, McINTYRE, Lauralyn A., SHEHATA, Nadine , van WALRAVEN, Carl, WILSON, Kumanan , TINMOUTH, Alan T.
Canadian Blood Services-CIHR Partnership Operating Grant Program 103806.0
Understanding brain death: a multipurpose educational video aimed to a diverse public and professional audience Principal Investigator: SHEMIE, Sam

Co-Investigator(s) / Trainee:
Small Project Funding Program 14000.0
Legal and policy strategies to optimize organ donation in Alberta Principal Investigator: TOEWS, Maeghan

Co-Investigator(s) / Trainee:
James Kreppner Fellowship Program 150000.0
Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPlba- and anti-GPllbllla-mediated thrombocytopenia? Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 378529.0
Microfluidic devices to measure the deformability of stored red blood cells Principal Investigator: MA, Hongshen

Co-Investigator(s) / Trainee: SCOTT, Mark D.
Canadian Blood Services-CIHR Partnership Operating Grant Program 398301.0
Elucidation of the mechanism of IVIG-associated hemolysis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: PENDERGRAST, Jacob , CSERTI-GAZDEWICH, Christine , SHEHATA, Nadine , PAVENSKI, Katerina , LAU, Wendy , CALLUM, Jeannie , LIN, Yulia , LIEBERMAN, Lani , HANNACH, Barbara
Intramural Research Grant Program 393712.0
Exploratory analyses to determine if method of donor blood processing affects outcome in transfused recipients Principal Investigator: HEDDLE, Nancy

Co-Investigator(s) / Trainee: ACKER, Jason P. , ARNOLD, Donald M. , COOK, Richard J. , EIKELBOOM, John W. , O'BRIEN, Sheila F. , WEBERT, Kathryn E.
Canadian Blood Services-CIHR Partnership Operating Grant Program 159878.0