Our Funded Research Projects

Updated April 2024

Title Principal Investigator / Supervisor Program Project Start Date Project End Date Total $ Awarded Sort descending
Role of blood component manufacturing on microvesicle-induced transfusion-related immune modulation Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: HOLOVATI, Jelena, BRANCH, Donald, ZHANG, Haibo
Intramural Research Grant Program 250660.0
Plasma transfusion or plasma protein product infusion in a murine model of trauma Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward
Intramural Research Grant Program 257414.8
Residual risk of transfusion-transmitted cytomegalovirus infection: incidence and pathogenesis Principal Investigator: PREIKSAITIS, Jutta

Co-Investigator(s) / Trainee: O'BRIEN, Sheila F., FEARON, Margaret, NAHIRNIAK, Susan
Intramural Research Grant Program 260451.0
Cold- versus room-temperature storage of platelets for bleeding in hematologic malignancy trials (CoVeRTS-HM Trial) Principal Investigator: MACK, Johnathan

Co-Investigator(s) / Trainee: TINMOUTH, Alan, FERGUSSON, Dean, SABLOFF, Mitchell
Blood Efficiency Accelerator Program 26385.0
IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes Principal Investigator: NING, Shuoyan

Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer
Intramural Research Grant Program 270352.1
Controlling coagulopathy and bleeding in a mouse model of hemorrhagic shock Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: NAZY, Ishac
Intramural Research Grant Program 274854.0
Can pre-operative anemia be timely identified and optimized in patients awaiting primary arthroplasty surgery? A randomized clinical trial Principal Investigator: GRAMMATOPOULOS, George

Co-Investigator(s) / Trainee: FERGUSSON, Dean, RAMSAY, Tim, TINMOUTH, Alan, GAGNE, Sylvain, MACK, Johnathan, BELZILE, Etienne, BEALE, Paul, THAVORN, Kednapa, TOUCHIE, Donna, GERMAIN, Genevieve, LAROCHE, Vincent
Intramural Research Grant Program 276081.0
Are cervical cancer brachytherapy outcomes associated with pre-brachytherapy hemoglobin values and transfusion practice? An observational study comparing two academic centres. Principal Investigator: SOLH, Ziad

Co-Investigator(s) / Trainee: LAZO-LANGER, Alejandro, D'SOUZA, David, CALLUM, Jeannie, LEUNG, Eric, CHIN-YEE, Ian
Blood Efficiency Accelerator Program 27669.5
TAD-POL (Transfusion-Associated-Dyspnea: Prospective observation and laboratory assessment) Principal Investigator: CSERTI-GAZDEWICH, Christine

Co-Investigator(s) / Trainee: BRANCH, Donald, LAZARUS, Alan, CALLUM, Jeannie, LIN, Yulia, PENDERGRAST, Jacob, LIEBERMAN, Lani, SHEHATA, Nadine, PAVENSKI, Katerina, SKEATE, Robert
Intramural Research Grant Program 278027.5
Influence of eryptosis and storage on transfused red cell recovery in sepsis Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: BRANCH, Donald, LIAW, Patricia, HEDDLE, Nancy, QADRI, Syed
Intramural Research Grant Program 283569.0
Red Cell Transfusion Rate and Allosensitization in Patients with End Stage Kidney Disease Principal Investigator: ZIMMERMAN, Deborah

Co-Investigator(s) / Trainee: FERGUSSON, Dean, FORSTER, Alan, KNOLL, Greg, CALLUM, Jeannie, TINMOUTH, Alan, MACK, Johnathan, CLARK, Edward, RAMSAY, Tim, PERELMAN, Iris
Blood Efficiency Accelerator Program 29015.7
A Simulation Model to Inform Best Practices for Inventory Management of Group O Negative Red Blood Cells Principal Investigator: RUTHERFORD, Alexander

Co-Investigator(s) / Trainee: BLAKE, John, SHIH, Andrew, MORRISON, Douglas, SAREMI, Alireza
Blood Efficiency Accelerator Program 29500.0
A study to understand C1 esterase inhibitor distribution and patterns of use in Canada Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: HEDDLE, Nancy, KEITH, Paul, WASERMAN, SUSAN, WEBERT, Kathryn, NING, Shuoyan, SHIH, Andrew, MORRISON, Doug, YAN, Matthew
Blood Efficiency Accelerator Program 29858.6
A machine learning based framework to analyze blood product transactional data for reducing discards Principal Investigator: CHENG, Calvino

Co-Investigator(s) / Trainee: ABIDI, Syed Sibte Raza, BLAKE, John, LIWSKI, Robert, QUINN, Jason, ABUSHAREKH, Ashraf, ABIDI, Samina, XIANG, Richard
Blood Efficiency Accelerator Program 29950.0
Blood utilization epidemiological profile to evaluate appropriate use (BLUE) Principal Investigator: ZELLER, Michelle

Co-Investigator(s) / Trainee: ARNOLD, Donald, WEBERT, Kathryn, HEDDLE, Nancy, NING, Shuoyan, BARTY, Rebecca
Blood Efficiency Accelerator Program 29964.0
Measurement of heavy metals in donor blood in Canada Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: SERRANO, Katherine, LEVIN, Elena, MURPHY, Michael, BARAKAUSKAS, Vilte, HADJESFAMDOARI, Narges, ARRIETA, Angele, RICHARDSON-SANCHEZ, Tomas
Blood Efficiency Accelerator Program 29971.0
Establishing national best practices for out-of-hospital blood transfusion: A collaboration of the Canadian Prehospital and Transport Transfusion (CAN-PATT) network Principal Investigator: NOLAN, Brodie

Co-Investigator(s) / Trainee: TROJANOWSKI, Jan, SHIH, Andrew, GREENE, Adam, EVANS, Rob, MULVEY, Jamin, CHANG, Eddie, NAHIRNIAK, Susan, PEARSON, Dallas, PROKOPCHUK-GAUK, Oksana, MARTIN, Doug, MUSUKA, Charles, SEIDL, Cindy, PEDDLE, Michael, LIN, Yulia, SMITH, Justin, MACDONALD, Scott, RICHARDS, Lindsay, FARRELL, Michael, KHANDELWAL, Aditi, CALLUM, Jeannie
Blood Efficiency Accelerator Program 30000.0
Blood product demand forecast modeling using clinical predictors Principal Investigator: DOWN, Douglas

Co-Investigator(s) / Trainee: BLAKE, John , TRIFUNOV, Rick, COURTNEY, Thomas, HEDDLE, Nancy, CHIANG, Fei, LI, Na
Blood Efficiency Accelerator Program 30000.0
Optimizing Pre-Chemotherapy Anemia in Gynecologic Oncology (OPRA-2): A quality improvement initiative Principal Investigator: VICUS, Danielle

Co-Investigator(s) / Trainee: SPÉNARD, Elisabeth, LIN, Yulia, KHANDELWAL, Aditi, TANO, Ruby, JADUNANDAN, Saudia, KNIGHT, Dawn
Blood Efficiency Accelerator Program 30000.0
Demonstration of genetic blood group transition in patients undergoing ABO-mismatched allogeneic hematopoietic stem cell transplantation by peripheral blood quantitative polymerase chain reaction targeting the ABO locus – Full Study Principal Investigator: MCGINNIS, ERIC

Co-Investigator(s) / Trainee: SHIH, Andrew, WANG, Xiu Qing, STUBBINS, Ryan, HUDOBA, Monika, PETRASZKO, Tanya
Blood Efficiency Accelerator Program 30000.0
Rationale, development, and feasibility of a prehospital transfusion registry Principal Investigator: NOLAN, Brodie

Co-Investigator(s) / Trainee: PEDDLE, Michael, LIN, Yulia, KHANDELWAL, Aditi, MCGOWAN, Melissa, TROJANOWSKI, Jan, SHIH, Andrew
Blood Efficiency Accelerator Program 30000.0
Hypothermic Storage as an Alternative to Irradiation of Red Cell Concentrates Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: CLARKE, Gwen, NAHIRNIAK, Susan, BRANDON-COATHAM, Mackenzie, OLAFSON, Carly
Blood Efficiency Accelerator Program 30000.0
Assessment of the quality of granulocyte concentrates to optimise their use in transfusion therapy Principal Investigator: FERNANDES, Maria

Co-Investigator(s) / Trainee: GIRARD, Melissa, BRANCH, Donald
Blood Efficiency Accelerator Program 30000.0
Informing the distribution of COVID-19 convalescent plasma through implementation of CONCOR-1 in British Columbia Principal Investigator: SHIH, Andrew

Co-Investigator(s) / Trainee: VASARHELYI, Krisztina, MANUSHA, Stephania Anna, STEINER, Ted, MCMASTER, Robert, DALY, Patricia, LI, Na, DOWN, Douglas, HEDDLE, Nancy, PETRASZKO, Tanya, LIOW, Eric, PAVLOVICH, Sasha, RUTHERFORD, Alexander
Blood Efficiency Accelerator Program 30000.0
Social media for knowledge translation and education 3 (SoMe-KTE3): Transfusion, thrombosis, and hemostasis Principal Investigator: SHIH, Andrew

Co-Investigator(s) / Trainee: CHAN, Teresa, DE WIT, Kristin, BHAGIRATH, Vinai, YEH, Calvin, CASTELLUCI, Lana, ELAHIE, Allahna, HEDDLE, Nancy, THOMA, Brent
BloodTechNet Award Program 30000.0
Optimizing rejuvenation to improve the product quality of pathogen-inactivation and γ-irradiated red cell concentrates Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: QADRI, Syed, SCHUBERT, Peter, DEVINE, Dana
Blood Efficiency Accelerator Program 30000.0
Rapid verification variant D phenotype by genotyping in a regional laboratory Principal Investigator: BERARDI, Philip

Co-Investigator(s) / Trainee: FUNG KEE FUNG, Karen, GIULIVI, Antonio, NEURATH, Doris, CLARKE, Gwen
Blood Efficiency Accelerator Program 30000.0
Transfusion requirements in cardiac surgery (TRICS II) Principal Investigator: SHEHATA, Nadine

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership New Investigator Program 300000.0
Code sepsis: defining and translating optimal resuscitation and care for children with septic shock Principal Investigator: PARKER, Melissa

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership New Investigator Program 300000.0
Antibodies to CD44 as a potential replacement for IVIg in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SEMPLE, John W., SHEFFIELD, William
Intramural Research Grant Program 300000.0
Enabling next generation hematopoietic-based therapeutics and manufacturing Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MCCOMB, Scott, JEZIERSKI, Anna, MAGALHAES, Ana, IQBAL, Umer
Intramural Research Grant Program 300000.0
Improving blood product quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: MA, Hongshen, JOHNSON, James, D'ALESSANDRO, Angelo
Intramural Research Grant Program 304462.0
Feasibility of implementing source plasma donation with alternative eligibility criteria for men who have sex with men Principal Investigator: PRESSEAU, Justin

Co-Investigator(s) / Trainee: GOLDMAN, Mindy, O'BRIEN, Sheila, MACPHERSON, Paul, OTIS, Joanne, GERMAIN, Marc, DEVINE, Dana, ROSSER, Andrew, LAPIERRE, Don
MSM Research Grant Program 309940.0
Understanding general population impact and opportunities from changes to blood donation deferral screening and criteria for men who have sex with men Principal Investigator: LACHOWSKY, Nathan

Co-Investigator(s) / Trainee: BRENNAN, David, CARD, Kiffer, DRYDEN, OmiSoore, GASPAR, Mark, GILBERT, Mark, GRACE, Daniel, KNIGHT, Rodney, LEBOUCHÉ, Bertrand, MORGAN, Jeffrey, SALWAY, Travis
MSM Research Grant Program 310000.0
Defining disease mechanisms in Immune Thrombocytopenia (ITP) and their association with clinical outcomes Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: COOK, Richard J., NAZY, Ishac
Canadian Blood Services-CIHR Partnership Operating Grant Program 317469.0
Characterization of the hematopoietic reconstitution enhancing activity of osteoblasts derived from human mesenchymal stromal cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: CAMPBELL, Pearl , GARNIER, Alain
Canadian Blood Services-CIHR Partnership Operating Grant Program 320504.0
Modulation of biofilm formation, virulence, and antimicrobial resistance by Staphylococcus aureus during platelet storage Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: SAD, Subash, MAH, Thien-Fah
Intramural Research Grant Program 323252.6
Virtual transfusions competency assessment Principal Investigator: VAN VLIET, Paula

Co-Investigator(s) / Trainee: DEYDEY, Kim, WESOLOWSKI, Mike
BloodTechNet Award Program 32795.0
Mechanisms of antibody-independent transfusion-related acute lung injury (TRALI) Principal Investigator: KUEBLER, Wolfgang

Co-Investigator(s) / Trainee: SEMPLE, John W.
Canadian Blood Services-CIHR Partnership Operating Grant Program 328712.0
A multifaceted intervention to optimize red blood cell transfusion practice in two provinces Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle
Intramural Research Grant Program 332942.0
Human monoclonal CD44 antibodies as potential IVIg replacements Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu
Intramural Research Grant Program 336000.0
Transfusion of red cells in hematopoietic stem cell transplantation: The TRIST Study Principal Investigator: TAY, Jason

Co-Investigator(s) / Trainee: ALLAN, David S. , COYLE, Douglas A. , FERGUSSON, Dean A. , TINMOUTH, Alan T. , WALKER, Irwin R
Canadian Blood Services-CIHR Partnership Operating Grant Program 340817.0
Addressing racial disparity in blood, stem cell, and organ and tissue donor pools Principal Investigator: FINGRUT, Warren

Co-Investigator(s) / Trainee: OKONOFUA, Sylvia, YAN, Matthew, KHANDELWAL, Aditi, PENDERGRAST, Jacob, LEEIES, Murdoch, TINGA, Biba, HAW, Jennie, JAGELAVICIUTE, Gabriela, ROSENFELD, Aaron, KHANOLKAR, Rutvij, SEGALL, Romy, BELLINI, Jonathan, MORAKINYO, Tobi, AGYEPONG, Revée
BloodTechNet Award Program 34150.0
Platelet microRNAs during storage under blood bank conditions Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: HITZLER, Walter
Canadian Blood Services-CIHR Partnership Operating Grant Program 349548.0
Development of internet modules for serology curriculum delivery Principal Investigator: YAN, Matthew

Co-Investigator(s) / Trainee: PENDERGRAST, Jacob, TAIT, Gordon
BloodTechNet Award Program 35500.0
Translating novel clotting factor X function to treat thrombosis Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: MACVICAR, Brian, SHEFFIELD, William
Intramural Research Grant Program 369052.0
Revisiting the universal donor: Does exposure to O blood products affect patient outcomes? Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: ACKER, Jason, BUCKSTEIN, Rena, CALLUM, Jeannie, COOK, Richard, HEDDLE, Nancy, SOLH, Ziad, WEBERT, Kathryn, BARTY, Rebecca, LEBER, Brian, LALIT, Saini
Intramural Research Grant Program 378365.0
Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPlba- and anti-GPllbllla-mediated thrombocytopenia? Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 378529.0
Improving the cryostorage of blood products using novel small molecule cryoprotectants Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: ACKER, Jason P. , ALLAN, David S.
Canadian Blood Services-CIHR Partnership Operating Grant Program 384180.0
Assessing the acceptability and feasibility of a plasma donation program for gbMSM in Montréal from the point of view of cis and trans gbMSM, volunteers from Héma-Québec, current donors, and plasma product recipients Principal Investigator: OTIS, Joanne

Co-Investigator(s) / Trainee: GERMAIN, Marc, HAW, Jennie, MONTEITH, Kenneth, MYHAL, Geneviève, PRESSEAU, Justin, PIRNAT, Bojan, LAPIERRE, Don
MSM Plasma Program 390970.0