Direct Antiglobulin Test (DAT)

Test description

This test is performed to determine whether a patient’s red blood cells have been sensitized in vivo with immunoglobulin, complement, or both. The DAT is used most commonly to investigate possible hemolytic transfusion reactions, Hemolytic Disease of the Fetus and Newborn (HDFN), autoimmune hemolytic anemia, and drug-induced immune hemolysis. The clinical significance of a DAT result should take into consideration the patient's clinical history, diagnoses, and other laboratory test results.

Direct Antiglobulin Test (PDF) 

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