Perinatal Testing Services - Winnipeg, MB

Canadian Blood Services, Winnipeg, MB Diagnostic Services Laboratory provides pregnancy screening for blood type and red blood cell antibodies. This screening provides information to assist physicians, midwives and nurse practitioners in ensuring the appropriate management of a pregnancy for both the mother and baby.

In addition, the Laboratory also provides serological investigation reference services to facilities that perform post natal testing.

Testing is provided by Winnipeg, MB Diagnostic Services for: Manitoba, north west Ontario, and facilities in Saskatchewan. 

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Recommended Perinatal Test Guidelines

Recommended Perinatal Test Guidelines MB

Canadian Blood Services (CBS) provides screening of pregnant women for blood type and red blood cell antibodies under a program funded by Manitoba Ministry of Health.This screening provides information to assist physicians, midwives and nurse practitioners in ensuring the appropriate management of a pregnancy for both the mother and baby.

Additional samples may be submitted for patients at increased risk of allo-immunization (previous transfusion, fetal trauma or procedure, IV  drug use, etc.).

Clinical scenarioSample submission timelines
First Pregnancy 
  • ABO and Rh(D) typing 
  • Red Cell Antibody Screen 
Initial visit and at 26-28 weeks gestation 
Rh positive – previous report on file – antibody screen negative 
  • ABO and Rh(D) typing 
  • Red Cell Antibody Screen 
Initial visit
Rh negative – antibody screen negative 
  • ABO and Rh(D) typing 
  • Red Cell Antibody Screen 
Initial visit and at 26-28 weeks gestation (sample to be collected prior to RhIG injection) Post Partum
Clinically significant antibodies detected 
  • ABO and Rh(D) typing 
  • Red Cell Antibody identification/exclusions 
  • Titration 
Maternal specimens are requested monthly for antibody titration and exclusion of other clinically significant antibodies. 
Mothers who have clinically significant antibodies with critical titres 
  • ABO and Rh(D) typing 
  • Red Cell Antibody identification / exclusions 

A clinically significant antibody will no longer be titered monthly once it has reached a critical value of ‘16’. 

If the clinically significant antibody identified is anti-K, titration is not required. Detection of anti-K is a critical result regardless of titre. 
Maternal specimens will be requested monthly for exclusion of other clinically significant antibodies. 

Father
  • ABO and Rh(D) typing 
  • Red Cell Phenotyping
When the mother has a clinically significant antibody the father’s sample is requested for phenotyping to predict the risk of hemolytic disease of the fetus and newborn (HDFN).
Cord / Neonate
  • ABO and Rh(D) typing 
  • Red Cell Phenotyping
  • DAT if required
When the mother is Rh negative or has a clinically significant antibody.
Available Perinatal Tests
Perinatal Requisitions and Forms

 

REQUISITIONS AND FORMS

Maternal Routine Testing (ABO/Rh Typing/Antibody Screen)                                                

Request for Perinatal Testing (PDF)
(Electronic Fillable Form)

Father's Rh Typing (when maternal Rh is negative) - when requested by Canadian Blood Services

Request for Perinatal Testing (PDF)
(Electronic Fillable Form)

Cord/Neonate  Testing (ABO/Rh/DAT - HDFN Investigation)

Request for Cord Neonate Blood Testing Requisition (PDF)

Post Natal Testing - Rh Negative Mothers

Request for Perinatal Testing (PDF)
(Electronic Fillable Form)

Fetal Bleed Screening Test (FMH Rapid Screen)

Request for Perinatal Testing (PDF)
(Electronic Fillable Form)

Kleihauer-Betke - Quantitative Test for Fetal Bleed

Request for Perinatal Testing (PDF)
(Electronic Fillable Form)

Fetal Genotyping from Maternal Plasma Requisitions

Testing is only available for Canadian residents. Please contact International Blood Group Reference Laboratory for testing inquires. https://ibgrl.blood.co.uk/services/molecular-diagnostics/fetal-genotyping-diagnostic/

International Blood Group Reference Laboratory (PDF)

Request for Perinatal Testing (PDF)
(Electronic Fillable Form)
Guidance for Completion of International Blood Group Laboratory Requistion
Fetal Genotyping on Maternal Plasma Updates (PDF)

Fetal Genotyping from Maternal Plasma Consent

Consent for Release of Neonatal Test Results (PDF)

Fetal Genotyping from Maternal Plasma Instructions

Fetal Genotyping on Maternal Plasma Collection Site Instructions (PDF)
Fetal Genotyping on Maternal Plasma Maternal Fetal Medicine Instructions (PDF)

Critical Values
Test interpretation — Perinatal critical values

Diagnostic Services will provide a verbal report to the requesting facility or physician in the following cases.

  • Rh positive mother where the Kleihauer Betke result indicates that a > 30 mL bleed has occurred due to trauma or at full term.
  • Positive DAT on cord blood or neonate sample.
  • Kleihauer-Betke result indicates that >1500 IU of RhIG is required..
  • Anti-K is detected in maternal sample (when first time detected in the pregnancy and/or with a new pregnancy).
  • Clinically significant antibody with a titre ≥ 16 in maternal sample (when first time detected in the pregnancy and/or with a new pregnancy). 
  • Positive Kleihauer-Betke result on a mother with an increased AFP.
Requesting Test Results

Perinatal patient test results are available by faxed request.

Monday to Friday: 7:30 a.m.–5 p.m. CT
Saturday and Sunday: 8 a.m.- 4 p.m. CT

Statutory holidays: 8 a.m.- 4 p.m. CT

Please use clinic/health care provider/hospital letterhead when requesting results and provide the following information:

  • Patient first and last name
  • PHIN (Personal Health Number)
  • Date of birth
  • Requesting physician
  • Facility/clinic fax number

Fax completed clinic/health care provider letterhead to Winnipeg Diagnostic Services at: 204-789-1006