Perinatal Testing Services - Winnipeg, MB
Test Catalogue
Recommended Perinatal Test Guidelines
Recommended Perinatal Test Guidelines MB
Canadian Blood Services (CBS) provides screening of pregnant women for blood type and red blood cell antibodies under a program funded by Manitoba Ministry of Health.This screening provides information to assist physicians, midwives and nurse practitioners in ensuring the appropriate management of a pregnancy for both the mother and baby.
Additional samples may be submitted for patients at increased risk of allo-immunization (previous transfusion, fetal trauma or procedure, IV drug use, etc.).
| Clinical scenario | Sample submission timelines |
|---|---|
First Pregnancy
| Initial visit and at 26-28 weeks gestation |
Rh positive – previous report on file – antibody screen negative
| Initial visit |
Rh negative – antibody screen negative
| Initial visit and at 26-28 weeks gestation (sample to be collected prior to RhIG injection) Post Partum |
Clinically significant antibodies detected
| Maternal specimens are requested monthly for antibody titration and exclusion of other clinically significant antibodies. |
Mothers who have clinically significant antibodies with critical titres
| A clinically significant antibody will no longer be titered monthly once it has reached a critical value of ‘16’. If the clinically significant antibody identified is anti-K, titration is not required. Detection of anti-K is a critical result regardless of titre. |
Father
| When the mother has a clinically significant antibody the father’s sample is requested for phenotyping to predict the risk of hemolytic disease of the fetus and newborn (HDFN). |
Cord / Neonate
| When the mother is Rh negative or has a clinically significant antibody. |
Available Perinatal Tests
- Maternal Routine Testing (ABO/Rh Typing/Antibody Screen)
- Father's Rh Typing (when maternal Rh is negative)
- Cord / Neonate Testing (ABO/Rh/DAT - HDFN Investigation)
- Post Natal Testing - Rh Negative Mothers
- Fetal Bleed Screening Test (FMH Rapid Screen)
- Kleihauer-Betke - Quantitative Test for Fetal Bleed
- RHD Genotyping
- Fetal Genotyping from Maternal Plasma
Perinatal Requisitions and Forms
REQUISITIONS AND FORMS | |
|---|---|
Maternal Routine Testing (ABO/Rh Typing/Antibody Screen) | Request for Perinatal Testing (PDF) |
Father's Rh Typing (when maternal Rh is negative) - when requested by Canadian Blood Services | Request for Perinatal Testing (PDF) |
| Cord/Neonate Testing (ABO/Rh/DAT - HDFN Investigation) | |
| Post Natal Testing - Rh Negative Mothers | Request for Perinatal Testing (PDF) |
| Fetal Bleed Screening Test (FMH Rapid Screen) | Request for Perinatal Testing (PDF) |
Kleihauer-Betke - Quantitative Test for Fetal Bleed | Request for Perinatal Testing (PDF) |
Fetal Genotyping from Maternal Plasma Requisitions Testing is only available for Canadian residents. Please contact International Blood Group Reference Laboratory for testing inquires. https://ibgrl.blood.co.uk/services/molecular-diagnostics/fetal-genotyping-diagnostic/ |
International Blood Group Reference Laboratory Requisition (PDF) (Use the link to download the Fetal Genotyping from Maternal Blood form FRM4674) Guidance for Completion of International Blood Group Laboratory Requisition |
Fetal Genotyping from Maternal Plasma Consent | |
Fetal Genotyping from Maternal Plasma Instructions | Fetal Genotyping on Maternal Plasma Collection Site Instructions (PDF) |
Critical Values
Test interpretation — Perinatal critical values
Diagnostic Services will provide a verbal report to the requesting facility or physician in the following cases.
- Rh positive mother where the Kleihauer Betke result indicates that a > 30 mL bleed has occurred due to trauma or at full term.
- Positive DAT on cord blood or neonate sample.
- Kleihauer-Betke result indicates that >1500 IU of RhIG is required..
- Anti-K is detected in maternal sample (when first time detected in the pregnancy and/or with a new pregnancy).
- Clinically significant antibody with a titre ≥ 16 in maternal sample (when first time detected in the pregnancy and/or with a new pregnancy).
- Positive Kleihauer-Betke result on a mother with an increased AFP.
Requesting Test Results
Perinatal patient test results are available by faxed request.
Monday to Friday: 7:30 a.m.–5 p.m. CT
Saturday and Sunday: 8 a.m.- 4 p.m. CT
Statutory holidays: 8 a.m.- 4 p.m. CT
Please use clinic/health care provider/hospital letterhead when requesting results and provide the following information:
- Patient first and last name
- PHIN (Personal Health Number)
- Date of birth
- Requesting physician
- Facility/clinic fax number
Fax completed clinic/health care provider letterhead to Winnipeg Diagnostic Services at: 204-789-1006