Sheffield, William

Selected Publications

  1. Eltringham-Smith LJ, Lei X, Reheman A, Lambourne MD, Pryzdial EL, Ni H, Sheffield WP: The fibrinogen but not the Factor VIII content of transfused plasma determines its effectiveness at reducing bleeding in coagulopathic mice. Transfusion 2015; 55:1040-1050.<
  2. Sheffield WP, Lambourne MD, Eltringham-Smith LJ, Bhakta V, Arnold DM, Crowther MA: γT -S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo. J Thromb Haemost 2014; 12:1110–1115.
  3. Lambourne MD, Eltringham‐Smith LJ, Gataiance S, Arnold DM, Crowther MA, Sheffield WP: Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate. J. Thromb Haemost 2012; 10:1830–1840.

Selected Publications

  1. Bhakta V, Jenkins C, Ramirez‐Arcos S, Sheffield WP: Stability of relevant plasma protein activities in cryosupernatant plasma units during refrigerated storage for up to 5 days postthaw. Transfusion 2014; 54:418–425.
  2. Sheffield WP, Bhakta V, Talbot K, Pryzdial ELG, Jenkins C: Quality of frozen transfusable plasma prepared from whole blood donations in Canada: An update. Transfus Apher Sci 2013; 49:440–446.
  3. Sheffield WP: ResearchUnit: Supporting evidence to change regulations regarding the storage of cryosupernatant plasma. 2013; website.
  4. Sheffield WP, Bhakta V, Jenkins C, Devine DV: Conversion to the buffy coat method and quality of frozen plasma derived from whole blood donations in Canada. Transfusion 2012; 50:1043–1049.

Selected Publications

  1. Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V: A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models. J Thromb Thrombolysis 2015; 39:443-51.
  2. Scott BM, Matochko WL, Gierczak RF, Bhakta V, Derda R, Sheffield WP: Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin. PLoS One 2014; 9:e84491.
  3. Bhakta V, Gierczak RF, Sheffield WP: Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity. J Biotech 2013; 168:373–381.

Leadership Role


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2009 - CurrentMember, Scientific and Medical Advisory Committee, Hema-Quebec