Our Research Publications

Updated August 2025

Title Authors Year Journal Link to Article Intended Audience Purpose
Manufacturing method affects mitochondrial DNA release and extracellular vesicle composition in stored red blood cells Bakkour S, Acker JP, Chafets DM, Inglis HC, Norris PJ, Lee TH, Busch MP 2016 Vox Sang View Researchers Basic research
Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis Alexander PE, Barty R, Fei Y, Vandvik PO, Pai M, Siemieniuk RA, Heddle NM, Blumberg N, McLeod SL, Liu J, Eikelboom JW, Guyatt GH 2016 Blood View Researchers Clinical research
Using simulation for strategic blood supply chain design in the Canadian prairies Blake J, McTaggart K 2016 Proceedings of the 6th International Conference on SIMULTECH View Blood operators New or improved product or process
Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study Heddle NM, Arnold DM, Acker JP, Liu Y, Barty RL, Eikelboom JW, Webert KE, Hsia CC, O'Brien SF, Cook RJ 2016 Lancet Haematol View Researchers Clinical research
Transfusion-transmitted malaria: is hope around the corner? O'Brien SF 2016 Lancet View Researchers Other
Acetylsalicyclic acid for the prevention and treatment of thromboembolic diseases Webert K, Kelton J 2016 Aspirin and related drugs View Health care providers Clinical research
Applications of Liposomes in Biopreservation Da Silveira Cavalcante L, Holovati J, Acker J 2016 Multiscale technologies for cryomedicine: implementation from nano to macroscale View Researchers Basic research
ResearchUnit: Data mining: digging for deeper understanding of blood components and transfusion outcomes Heddle NM, Acker JP 2016 Blood.ca website View Other Other
Strain-promoted azide-alkyne cycloaddition for protein-protein coupling in the formation of a bis-hemoglobin as a copper-free oxygen carrier Singh S, Dubinsky-Davidchik IS, Kluger R 2016 Org Biomol Chem View Researchers Basic research
Quality and Safety of Blood Products Ramirez-Arcos S, Marks DC, Acker JP, Sheffield WP 2016 J Blood Transfus View Researchers Other
ResearchUnit: Older blood as good as new: no harmful effects of storage time before transfusion Heddle N 2016 Blood.ca website View Other Other
Comments on: Bernardo et al. 2016 (Blood)Working together to block alloimmunization Stowell SR 2016 Blood View Researchers Basic research
Introducing the red cell storage lesion Chen D, Serrano K, Devine DV 2016 ISBT Sci Ser View Blood operators Basic research
Myasthenia gravis treated with autologous hematopoietic stem cell transplantation Bryant A, Atkins H, Pringle C, Allan D, Anstee G, Bence-Bruckler I, Hamelin L, Hodgins M, Hopkins HS, Huebsch L, McDiarmid S, Sabloff M, Sheppard D, Tay J, Bredeson C 2016 JAMA Neurol View Researchers Clinical research
Plasma and cryoprecipitate for transfusion Stanworth SJ, Tinmouth AT 2016 Rossi's Principles of Transfusion Medicine View Researchers Basic research
Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia Kapur R, Aslam R, Kim M, Guo L, Ni H, Segel GB, Semple JW 2016 Platelets View Researchers Basic research
Raman spectroscopy as a novel tool for monitoring biochemical changes and inter-donor variability in stored red blood cell units Atkins CG, Buckley K, Chen D, Schulze HG, Devine DV, Blades MW, Turner RFB 2016 Analyst View Researchers New or improved product or process
Stability of coagulation protein activities in single units or pools of cryoprecipitate during storage at 20–24°C for up to 24 h Sheffield WP, Bhakta V, Jenkins C 2016 Vox Sang View Blood operators New or improved product or process
Targeting FcRs to treat antibody-dependent autoimmunity Yu X, Lazarus AH 2016 Autoimmun Rev View Researchers Other
Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2 Kapur R, Semple JW 2016 Ann Transl Med View Researchers Basic research
Dengue virus persists and replicates during storage of platelet and red blood cell units Sutherland MR, Simon AY, Serrano K, Schubert P, Acker JP, Pryzdial ELG 2016 Transfusion View Researchers Basic research
Effects of methoxypoly (Ethylene glycol) mediated immunocamouflage on leukocyte surface marker detection, cell conjugation, activation and alloproliferation Kyluik-Price DL, Scott MD 2016 Biomaterials View Researchers Basic research
Evaluating the "family veto" of consent for organ donation Toews M, Caulfield T 2016 CMAJ View Health care providers Other
ResearchUnit: Hijacked: the role of platelets in dengue virus infection revealed Pryzdial EL 2016 Blood.ca website View Other Other
Resolving variable maternal D typing using serology and genotyping in selected prenatal patients Clarke G, Hannon J, Berardi P, Barr G, Cote J, Fallis R, Alport T, Lane D, Petraszko T, Ochoa G, Goldman M 2016 Transfusion View Health care providers New or improved product or process
Self-Assembly of a Functional Triple Protein: Hemoglobin-Avidin-Hemoglobin via Biotin–Avidin Interactions Singh S, Kluger R 2016 Biochemistry View Researchers Basic research
The nonhemostatic immune functions of platelets Kapur R, Semple JW 2016 Semin Hematol View Researchers Basic research
Thrombocytopenic syndromes in pregnancy Yan M, Malinowski AK, Shehata N 2016 Obstet Med View Health care providers Clinical research
Corticosteroids compared with intravenous immunoglobulin for the treatment of immune thrombocytopenia in pregnancy Sun D, Shehata N, Ye XY, Gregorovich S, De France B, Arnold DM, Shah PS, Malinowski AK 2016 Blood View Researchers Clinical research
Monovalent Fc receptor blockade by an anti-Fc? receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity Yu X, Menard M, Prechl J, Bhakta V, Sheffield WP, Lazarus AH 2016 Blood View Researchers Basic research
Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies Xu XR, Carrim N, Neves MAD, McKeown T, Stratton TW, Coelho RMP, Lei X, Chen P, Xu J, Dai X, Li BX, Ni H 2016 Thromb J View Health care providers Clinical research
Transfusion-related alloimmunization in children: epidemiology and effects of chemotherapy Solh Z, Athale U, Arnold DM, Cook RJ, Foley R, Heddle NM 2016 Vox Sang View Health care providers Clinical research
Quality assessment of established and emerging blood components for transfusion Acker J, Marks DC, Sheffield W 2016 J Blood Transfus View Blood operators Benchmarking and standard setting
Impact of informing donors of low ferritin results Goldman M, Uzicanin S, Scalia J, Scalia V, O'Brien SF 2016 Transfusion View Blood operators Clinical research
Introduction of a closed-system cell processor for red blood cell washing: postimplementation monitoring of safety and efficacy Acker JP, Hansen AL, Yi Q-L, Sondi N, Cserti-Gazdewich C, Pendergrast J, Hannach B 2016 Transfusion View Blood operators New or improved product or process
Oxford's Systematic Review Initiative: leading by example in evidence-based transfusion medicine Fergusson DA 2016 Transfus Med View Researchers Clinical research
ResearchUnit: Mastering the monocyte monolayer assay Branch D 2016 Blood.ca website View Other Other
RhoA/ROCK signaling contributes to sex differences in the activation of human platelets Schubert P, Coupland D, Nombalais M, Walsh G, Devine DV 2016 Thromb Res View Researchers Basic research
Shining a light on AHG "blind" spot(s) Branch DR, Westhoff CM 2016 Transfusion View Researchers Basic research
Understanding stakeholder important outcomes and perceptions of equity, acceptability and feasibility of a care model for haemophilia management in the US: a qualitative study Lane SJ, Sholapur NS, Yeung CH, Iorio A, Heddle NM, Sholzberg M, Pai M 2016 Haemophilia View Health care providers Other
Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice Bernardo L, Amash A, Marjoram D, Lazarus AH 2016 Blood View Researchers Basic research
Mitochondrial Inner Membrane Depolarization as a Marker of Platelet Apoptosis: Disclosure of Nonapoptotic Membrane Depolarization Gyulkhandanyan AV, Allen DJ, Mykhaylov S, Lyubimov E, Ni H, Freedman J, Leytin V 2016 Clin Appl Thromb Hemost View Researchers Basic research
Noninvasive pH monitoring for bacterial detection in platelet concentrates Loza-Correa M, Perkins H, Kumaran D, Kou Y, Qaisar R, Geelhood S, Ramirez-Arcos S 2016 Transfusion View Researchers New or improved product or process
Platelet microparticles reprogram macrophage gene expression and function Laffont B, Corduan A, Rousseau M, Duchez AC, Lee CH, Boilard E, Provost P 2016 Thromb Haemost View Researchers Basic research
Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells Aslam R, Segel GB, Burack R, Spence SA, Speck ER, Guo L, Semple JW 2016 Br J Haematol View Researchers Basic research
The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation Lewis JK, Bischof JC, Braslavsky I, Brockbank KGM, Fahy GM, Fuller BJ, Rabin Y, Tocchio A, Woods EJ, Wowk BG, Acker JP, Giwa S 2016 Cryobiology View Researchers Other
The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia Aslam R, Kapur R, Segel GB, Guo L, Zufferey A, Ni H, Semple JW 2016 Exp Hematol View Researchers Basic research
Transfusion premedication practices among pediatric health care practitioners in Canada: results of a national survey Solh Z, Chan AK, Heddle NM 2016 Transfusion View Health care providers Clinical research
The Ottawa criteria for the appropriate use of perioperative blood transfusions in liver resection using the RAND/UCLA appropriateness method. Bennett S, Fergusson D, Tinmouth A, McIsaac D, Pawlik T, Hebert P, Mcintyre L, Karanicolas P, Barkun J, Turgeon-Fournier A 2016 Can J Surg View Health care providers Clinical research
Acquired Factor XIII Inhibitor in Hospitalized and Perioperative Patients: A Systematic Review of Case Reports and Case Series Tone KJ, James TE, Fergusson DA, Tinmouth A, Tay J, Avey MT, Kilty S, Lalu MM 2016 Transfus Med Rev View Researchers Clinical research