Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model Brinc D, Le-Tien H, Crow AR, Semple JW, Freedman J, Lazarus AH 2010 Transfusion View Researchers Basic research
Using Raman spectroscopy to assess hemoglobin oxygenation in red blood cell concentrate: an objective proxy for morphological index to gauge the quality of stored blood? Atkins CG, Schulze HG, Chen D, Devine DV, Blades MW, Turner RF 2017 Analyst View Researchers New or improved product or process
Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties Abu-Khader A, Law KW, Jahan S, Manesia JK, Pasha R, Hovey O, Pineault N 2019 Stem Cells View Researchers Basic research
Initial flow cytometric evaluation of the Clearllab lymphoid screen Hedley BD, Cheng G, Luider J, Kern W, Lozanski G, Chin-Yee I, Lowes LE, Keeney M, Careaga D, Magari R, Tejidor L 2018 Cytometry B Clin Cytom View Researchers Basic research
Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia: a systematic review Kjaer M, Bertrand G, Bakchoul T, Massey E, Baker JM, Lieberman L, Tanael S, Greinacher A, Murphy MF, Arnold DM, Baidya S, Bussel J, Hume H, Kaplan C, Oepkes D, Ryan G, Savoia H, Shehata N, Kjeldsen-Kragh J, International Collaboration for Transfusion Medicine Guidelines 2018 Vox Sang View Researchers Clinical research
Hemostatic efficacy of pathogen-inactivated versus untreated platelets: a randomized controlled trial van der Meer PF, Ypma PF, van Geloven N, van Hilten JA, van Wordragen-Vlaswinkel RJ, Eissen O, Zwaginga JJ, Trus M, Beckers EAM, te Boekhorst P, Tinmouth A, Lin Y, Hsia C, Lee D, Norris PJ, Goodrich RP, Brand A, Hervig T, Heddle NM, van der Bom JG, Kerkhoffs J-LH 2018 Blood View Researchers Clinical research
Alpha-Dystroglycan Supports Platelet Aggregation and Thrombus Formation Wang Y, Gallant RC, Neves MAD, Lei X, Gupta S, Coelho R, Wong T, Cohn RD, Campbell KP, Ni H 2019 Blood View Researchers Basic research
Defining certainty of net benefit: a GRADE concept paper Alper BS, Oettgen P, Kunnamo I, Iorio A, Ansari MT, Murad MH, Meerpohl JJ, Qaseem A, Hultcrantz M, Schunemann HJ, Guyatt G, GRADE Working Group 2019 BMJ Open View Researchers Clinical research
Human red blood cell stroma: an alternative to traditional allogeneic adsorption methods Wilson EM, Branch DR 2019 Transfusion View Researchers Basic research
A call for caution in use of pertussis vaccine effectiveness studies to estimate waning immunity: A Canadian Immunization Research Network Study Crowcroft NS, Schwartz KL, Savage RD, Chen C, Johnson C, Li Y, Marchand-Austin A, Bolotin S, Deeks SL, Jamieson FB, Drews SJ, Russell ML, Svenson LW, Simmonds K, Righolt CH, Bell C, Mahmud SM, Kwong JC 2020 Clin Infect Dis View Researchers Clinical research
The efficacy of ice recrystallization inhibitors in rat lung cryopreservation using a low cost technique for ex vivo subnormothermic lung perfusion Lautner L, Himmat S, Acker JP, Nagendran J 2020 Cryobiology View Researchers Basic research
Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress Ariens R, Becattini C, Bender M, Bergmeier W, Castoldi E, Devreese K, Ellis M, Gailani D, Ignjatovic V, James PD, Kerrigan S, Lambert M, Lee LH, Levi M, Maugeri N, Meijers J, Melero-Martin J, Michelson AD, Mingozzi F, Neeves K, Ni H, Olsson A-K, Prohászka Z, Ranson M, Riva N, Senis Y, van Ommen CH, Vaughan DE, Weisel J 2020 J Thromb Haemost View Researchers Basic research
New insights into IVIg mechanisms and alternatives in autoimmune and inflammatory diseases Norris PAA, Kaur G, Lazarus AH 2020 Curr Opin Hematol View Researchers Basic research
The timing of gamma irradiation and its effect on cell-free and microvesicle-bound hemoglobin. The BEST collaborative study William N, Bicahlo B, Hansen A, de Korte D, Acker JP, Biomedical Excellence for Safer Transfusion Collaborative 2022 Transfusion View Researchers Basic research
Necrotizing enterocolitis and mortality after transfusion of ABO non-identical blood Parvizian MK, Barty R, Heddle NM, Li N, McDougall T, Mukerji A, Fusch C, Solh Z 2021 Transfusion View Researchers Clinical research
Mechanism of increased efficacy of recombinant Fc-?TP-L309C compared to IVIg to ameliorate mouse immune thrombocytopenia Lewis BJB, Binnington B, Blacquiere M, Spirig R, Käsermann F, Branch DR 2021 eJHaem View Researchers Basic research
The SSC platelet immunology register of VITT and VIITP: Toward standardization of laboratory and clinical parameters Choi PY, Grace RF, Therese Ahlen M, Nazy I, Sachs UJ, Arnold DM, McKenzie SE, Althaus K, Sharma R, Bakchoul T 2021 J Thromb Haemost View Researchers Benchmarking and standard setting
Determining the Optimal SARS-CoV-2 mRNA Vaccine Dosing Interval for Maximum Immunogenicity Asamoah-Boaheng M, Goldfarb D, Prusinkiewicz MA, Golding L, Karim ME, Barakauskas V, Wall N, Jassem AN, Marquez AC, MacDonald C, O'Brien SF, Lavoie P, Grunau B 2023 Cureus View Researchers Clinical research
Staphylococcal Enterotoxins Enhance Biofilm Formation by Staphylococcus aureus in Platelet Concentrates Chi SI, Ramirez-Arcos S 2023 Microorganisms View Researchers Basic research
‘A Most Equitable Drug’: How the Clinical Studies of Convalescent Plasma as a Treatment for SARS-CoV-2 Might Usefully Inform Post-Pandemic Public Sector Approaches to Drug Development Grundy Q, Campbell C, Ali R, Herder M, Holloway K 2023 J Law Med Ethics View Researchers Ethical, legal & social implications research
Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM 2022 Transfusion View Researchers Clinical research
Severe fetal anemia caused by anti-Jra: Burst forming unit-erythroid colony formation inhibition assay suggesting possible erythroid suppression mechanism Tran A, Yan MTS, Branch DR, Blacquiere M, Pineault N, Pasha R, Clarke G 2023 Transfusion View Researchers Clinical research
A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP) Kapur R, Catalina MD, Aslam R, Speck ER, Francovitch RF, Semple JW 2017 Br J Haematol View Researchers Basic research
Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2 Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Foller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM 2015 Sci Rep View Researchers Basic research
Cancer and platelet crosstalk: opportunities and challenges for aspirin and other anti-platelet agents Xu XR, Yousef GM, Ni H 2018 Blood View Researchers Basic research
Concentré de recherche: Vers une uniformisation des politiques d'exclusion du don de sang et de plasma Goldman M, O'Brien S, Devine D 2018 Blood.ca website View Researchers Basic research
Fibronectin orchestrates thrombosis and hemostasis Wang Y, Carrim N, Ni H 2015 Oncotarget View Researchers Other
Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial Atkins HL, Bowman M, Allan D, Anstee G, Arnold DL, Bar-Or A, Bence-Bruckler I, Birch P, Bredeson C, Chen J, Fergusson D, Halpenny M, Hamelin L, Huebsch L, Hutton B, Laneuville P, Lapierre Y, Lee H, Martin L, McDiarmid S, O'Connor P, Ramsay T, Sabloff M, Walker L, Freedman MS 2016 Lancet View Researchers Clinical research
Pathogen inactivation treatment of plasma and platelet concentrates and their predicted functionality in massive transfusion protocols Arbaeen AF, Schubert P, Serrano K, Carter CJ, Culibrk B, Devine DV 2017 Transfusion View Researchers Basic research
Platelet immunobiology: platelets as prey and predator Kapur R, Semple JW 2018 ISBT Sci Ser View Researchers Basic research
Rationale and Design of the Informing Fresh versus Old Red Cell Management (INFORM) Trial: An International Pragmatic Randomized Trial Eikelboom JW, Cook RJ, Barty R, Liu Y, Arnold DM, Crowther MA, Devereaux PJ, Ellis M, Figueroa P, Gallus A, Hirsh J, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warkentin TE, Webert KE, Heddle NM 2016 Transfus Med Rev View Researchers Clinical research
Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality Almizraq R, Tchir JD, Holovati JL, Acker JP 2013 Transfusion View Researchers Basic research
The M358R variant of α1-proteinase inhibitor inhibits coagulation factor VIIa Sheffield WP, Bhakta V 2016 Biochem Biophys Res Commun View Researchers Basic research
Therapeutic cells via functional modification: Influence of molecular properties of polymer grafts on in vivo circulation, clearance, immunogenicity and antigen protection Chapanian R, Constantinescu I, Medvedev N, Scott MD, Brooks DE 2013 Biomacromolecules View Researchers Basic research
Managing antithrombotic therapy in immune thrombocytopenia: development of the TH2 risk assessment score Balitsky AK, Kelton JG, Arnold DM 2018 Blood View Researchers New or improved product or process
The first case of severe acute hemolytic transfusion reaction caused by anti-Sc2 Lemay A-S, Tong TN, Branch DR, Huang M, Sumner C, Oldfield L, Hawes J, Cserti-Gazdewich CM, Lau W 2018 Transfusion View Researchers Clinical research
Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial Pai M, Adhikari NKJ, Ostermann M, Heels-Ansdell D, Douketis JD, Skrobik Y, Qushmaq I, Meade M, Guyatt G, Geerts W, Walsh MW, Crowther MA, Friedrich JO, Burry L, Bellomo R, Brandao da Silva N, Costa Filho R, Cox MJ, Alves Silva S, Cook DJ, on behalf of the PROTECT Investigators 2018 PLoS One View Researchers Clinical research
Ultraviolet-based pathogen inactivation systems: untangling the molecular targets activated in platelets Schubert P, Johnson L, Marks DC, Devine DV 2018 Front Med View Researchers Basic research
Intravenous immunoglobulin (IVIg) or IVIg-treated macrophages reduce DSS-induced colitis by inducing macrophage IL-10 production Kozicky LK, Menzies SC, Hotte N, Madsen KL, Sly LM 2019 Eur J Immunol View Researchers Basic research
Platelet rich plasma in treatment of musculoskeletal pathologies Mehrabani D, Seghatchian J, Acker JP 2019 Transfus Apher Sci View Researchers Basic research
Aging, chronic inflammation, and platelet hyperactivity Ma W, Karakas D, Chen ZY, Ni H 2020 Ann Blood View Researchers Basic research
A crosswalk tabular review on methods and outcomes from randomized clinical trials using pathogen reduced platelets Rebulla P, Garban F, van der Meer PF, Heddle NM, McCullough J 2020 Transfusion View Researchers Clinical research
Update on newer approaches to prevent or treat COVID-19 infection: What we all need the most right now!! Seghatchian J, Acker JP, Putter JS 2020 Transfus Apher Sci View Researchers New or improved product or process
Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K 2021 J Thromb Haemost View Researchers Clinical research
Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis Siemieniuk RA, Bartoszko JJ, Díaz Martinez JP, Kum E, Qasim A, Zeraatkar D, Izcovich A, Mangala S, Ge L, Han MA, Agoritsas T, Arnold D, Ávila C, Chu DK, Couban R, Cusano E, Darzi AJ, Devji T, Foroutan F, Ghadimi M, Khamis A, Lamontagne F, Loeb M, Miroshnychenko A, Motaghi S, Murthy S, Mustafa RA, Rada G, Rochwerg B, Switzer C, Vandvik PO, Vernooij RW, Wang Y, Yao L, Guyatt GH, Brignardello-Petersen R 2021 BMJ View Researchers Clinical research
Hemolysis after high-dose intravenous immunoglobulin: An under-appreciated sequelae Branch DR, Almizraq RJ, Bussel JB 2022 Am J Hematol View Researchers Basic research
Prolonged Blood Storage and Risk of Posttransfusion Acute Kidney Injury Adegboye J, Sapatnekar S, Mascha EJ, Shah K, Lioudis M, Essber H, Cohen B, Rivas E, Heddle NM, Eikelboom JW, Ellis MH, Sharon Y, Sinha R, Kurz A, Sessler DI 2022 Anesthesiology View Researchers Clinical research
A critical contribution in a time of crisis: Examining motivations and deterrents to COVID-19 convalescent plasma donation and future donation intentions among prospective Canadian donors Holloway K, Campbell C, Ali R, Huyer LD, Hart D, Haw J, Brennenstuhl S, Grundy Q 2022 Transfus Med View Researchers Ethical, legal & social implications research
Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude Li M, Tang X, Liao Z, Shen C, Cheng R, Fang M, Wang G, Li Y, Tang S, Xie L, Zhang Z, Kamau PM, Mwangi J, Lu Q, Li Y, Wang Y, MacKeigan DT, Cerenzia EG, Ni H, Lai R 2022 Blood View Researchers Basic research
RE: A better normal in Canada will need a better detection system for emerging and re-emerging respiratory pathogens O'Brien S, Goldman M, Drews S 2022 CMAJ View Researchers Clinical research