Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice Chen J, Reheman A, Gushiken FC, Nolasco L, Fu X, Moake JL, Ni H, Lopez JA 2011 J Clin Invest View Researchers Basic research
Oxford's Systematic Review Initiative: leading by example in evidence-based transfusion medicine Fergusson DA 2016 Transfus Med View Researchers Clinical research
Polymer-mediated immunocamouflage of red blood cells: effects of polymer size on antigenic and immunogenic recognition of allogeneic donor blood cells Wang D, Kyluik DL, Murad KL, Toyofuku WM, Scott MD 2011 Sci China Life Sci View Researchers Basic research
Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate Lambourne MD, Eltringham-Smith LJ, Gataiance S, Arnold DM, Crowther MA, Sheffield WP 2012 J Thromb Haemost View Researchers Basic research
Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy Deng X, Duffy SP, Myrand-Lapierre M-E, Matthews K, Santoso AT, Du Y-L, Ryan KS, Ma H 2015 Malar J View Researchers New or improved product or process
RhoA/ROCK signaling contributes to sex differences in the activation of human platelets Schubert P, Coupland D, Nombalais M, Walsh G, Devine DV 2016 Thromb Res View Researchers Basic research
Shining a light on AHG "blind" spot(s) Branch DR, Westhoff CM 2016 Transfusion View Researchers Basic research
The effects of rejuvenation during hypothermic storage on red blood cell membrane remodeling Kurach JDR, Almizraq R, Bicalho B, Acker JP, Holovati JL 2014 Transfusion View Researchers Basic research
The potential utility of methoxypoly(ethylene glycol)-mediated prevention of rhesus blood group antigen RhD recognition in transfusion medicine Wang D, Toyofuku WM, Scott MD 2012 Biomaterials View Researchers Basic research
Two-year follow-up of donors in a large national study of ferritin testing Goldman M, Uzicanin S, Osmond L, Yi Q-L, Scalia V, O'Brien SF 2018 Transfusion View Researchers Clinical research
Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial Karkouti K, Callum J, Rao V, Heddle N, Farkouh ME, Crowther MA, Scales DC 2018 BMJ Open View Researchers Clinical research
Red blood cells, still vital after all these years: Commentary on Canadian Blood Services' International Symposium 2017 Qadri SM, Donkor DA, Yan M, Ning S, Branch DR, Seghatchian J, Sheffield WP 2018 Transfus Apher Sci View Researchers Other
Megakaryocyte apoptosis in immune thrombocytopenia Vrbensky JR, Nazy I, Toltl LJ, Ross C, Ivetic N, Smith JW, Kelton JG, Arnold DM 2018 Platelets View Researchers Basic research
The association between influenza vaccination and socioeconomic status in high income countries varies by the measure used: a systematic review Lucyk K, Simmonds KA, Lorenzetti DL, Drews SJ, Svenson LW, Russell ML 2019 BMC Med Red Methodol View Researchers Clinical research
Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization McEneny-King A, Chelle P, Foster G, Keepanasseril A, Iorio A, Edginton AN 2019 J Pharmacokinet Pharmacodyn View Researchers Clinical research
The Impact of Bacterial Biofilms in Transfusion Medicine Ramirez-Arcos S 2020 Racing for the Surface View Researchers Basic research
Optimizing the supply of whole blood-derived bioproducts through the combined implementation of cryopreservation and pathogen reduction technologies and practices: An overview Bohonek M, Kutac D, Acker JP, Seghatchian J 2020 Transfus Apher Sci View Researchers New or improved product or process
Sex-mismatched red blood cell transfusions and mortality: A systematic review and meta-analysis Zeller MP, Rochwerg B, Jamula E, Li N, Hillis C, Acker JP, Runciman RJR, Lane SJ, Ahmed N, Arnold DM, Heddle NM 2019 Vox Sang View Researchers Clinical research
Cardiac donation after circulatory determination of death: protocol for a mixed-methods study of healthcare provider and public perceptions in Canada Honarmand K, Ball I, Weiss M, Slessarev M, Sibbald R, Sarti A, Meade M, D'Aragon F, Chasse M, Basmaji J, Parsons Leigh J 2020 BMJ Open View Researchers New or improved product or process
Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives William N, Acker JP 2020 Cryobiology View Researchers Basic research
Opportunities for standardization of cold stored, low-titre group O WB products Acker JP, Seghatchian J 2020 Transfus Apher Sci View Researchers New or improved product or process
ResearchUnit: Donating blood before pregnancy is safe for mothers and babies Chassé M 2020 Blood.ca website View Researchers Clinical research
Spontaneous HIT syndrome: Knee replacement, infection, and parallels with vaccine-induced immune thrombotic thrombocytopenia Warkentin TE, Greinacher A 2021 Thromb Res View Researchers Clinical research
Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity Himbert S, Qadri SM, Sheffield WP, Schubert P, D’Alessandro A, Rheinstädter MC 2021 PLoS One View Researchers Basic research
Spotlight on animal models of acute traumatic coagulopathy: An update Ask A, Eltringham-Smith L, Bhakta V, Donkor DA, Pryzdial ELG, Sheffield WP 2022 Transfus Apher Sci View Researchers Basic research
A naturally present autoantibody to senescent red blood cells? Badior KE, Bloch EM, Branch DR 2022 Transfusion View Researchers Benchmarking and standard setting
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency Dahal S, Clayton K, Been T, Fernet-Brochu R, Ocando AV, Balachandran A, Poirier M, Maldonado RK, Shkreta L, Boligan KF, Guvenc F, Rahman F, Branch D, Bell B, Chabot B, Gray-Owen SD, Parent LJ, Cochrane A 2022 Retrovirology View Researchers Basic research
A data-driven approach to determine daily platelet order quantities at hospitals Mirjalili M, Abouee-Mehrizi H, Barty R, Heddle NM, Sarhangian V 2022 Transfusion View Researchers New or improved product or process
Unique features of vaccine-induced immune thrombotic thrombocytopenia; a new anti-platelet factor 4 antibody-mediated disorder Venier LM, Clerici B, Bissola AL, Modi D, Jevtic SD, Radford M, Mahamad S, Nazy I, Arnold DM 2023 Int J Hematol View Researchers Clinical research
A method to measure permeability of red blood cell membrane to water and solutes using intrinsic fluorescence Zhurova M, Olivieri A, Holt A, Acker JP 2014 Clin Chim Acta View Researchers Basic research
Acquired Factor XIII Inhibitor in Hospitalized and Perioperative Patients: A Systematic Review of Case Reports and Case Series Tone KJ, James TE, Fergusson DA, Tinmouth A, Tay J, Avey MT, Kilty S, Lalu MM 2016 Transfus Med Rev View Researchers Clinical research
Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Crow AR, Song S, Suppa SJ, Ma S, Reilly MP, Andre P, McKenzie SE, Lazarus AH 2011 Blood View Researchers Basic research
Approaches for analysis of erythroid cell parameters and hemoglobinopathies in mouse models Trudel M, Sedzro JC 2018 Methods Mol Biol View Researchers Basic research
Cationic liposome-mediated CXCR4 gene delivery into hematopoietic stem/progenitor cells: implications for clinical transplantation and gene therapy Gul-Uludag H, Xu P, Marquez-Curtis LA, Xing J, Janowska-Wieczorek A, Chen J 2012 Stem Cells Dev View Researchers Basic research
Clinical effects of blood donor characteristics in transfusion recipients: protocol of a framework to study the blood donor-recipient continuum Chasse M, McIntyre L, Tinmouth A, Acker J, English SW, Knoll G, Forster A, Shehata N, Wilson K, van Walraven C, Ducharme R, Fergusson DA 2015 BMJ Open View Researchers Other
Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia Li C, Chen P, Vadasz B, Ma L, Zhou H, Lang S, Freedman J, Ni H 2013 Thromb Haemost View Researchers Basic research
Determining the Volume of Additive Solution and Residual Plasma in Whole Blood Filtered and Buffy Coat Processed Red Cell Concentrates Jordan A, Acker J 2015 Transfus Med Hemother View Researchers New or improved product or process
Endothelial-Specific Deletion of Autophagy Related 7 (ATG7) Attenuates Arterial Thrombosis in Mice Yau JW, Singh KK, Hou Y, Lei X, Ramadan A, Quan A, Teoh H, Kuebler WM, Al-Omran M, Yanagawa B, Ni H, Verma S 2017 J Thorac Cardiovasc Surg View Researchers Basic research
Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: Further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells Jalili A, Shirvaikar N, Marquez-Curtis L, Qiu Y, Korol C, Lee H, Turner AR, Ratajczak MZ, Janowska-Wieczorek A 2010 Exp Hematol View Researchers Basic research
Immunocamouflaged RBC for alloimmunized patients Scott M, Toyofuku W, Yang X, Raj M, Kang N 2017 Transfusion Medicine and Scientific Developments View Researchers Basic research
Induction of immunotolerance via mPEG grafting to allogeneic leukocytes Wang D, Toyofuku WM, Chen AM, Scott MD 2011 Biomaterials View Researchers Basic research
IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist von Gunten S, Shoenfeld Y, Blank M, Branch DR, Vassilev T, Kasermann F, Bayry J, Kaveri S, Simon HU 2014 Nat Rev Immunol View Researchers Other
Maternal anti-platelet beta-3 integrins impair angiogenesis and cause intracranial hemorrhage Yougbaré I, Lang S, Yang H, Chen P, Zhao X, Tai W-S, Zdravic D, Vadasz B, Li C, Piran S, Marshall A, Zhu G, Tiller H, Killie MK, Boyd S, Leong-Poi H, Wen X-Y, Skogen B, Adamson SL, Freedman J, Ni H 2015 J Clin Invest View Researchers Basic research
Mitochondrial Inner Membrane Depolarization as a Marker of Platelet Apoptosis: Disclosure of Nonapoptotic Membrane Depolarization Gyulkhandanyan AV, Allen DJ, Mykhaylov S, Lyubimov E, Ni H, Freedman J, Leytin V 2016 Clin Appl Thromb Hemost View Researchers Basic research
Noninvasive pH monitoring for bacterial detection in platelet concentrates Loza-Correa M, Perkins H, Kumaran D, Kou Y, Qaisar R, Geelhood S, Ramirez-Arcos S 2016 Transfusion View Researchers New or improved product or process
Pathogenesis of immune thrombocytopenia Cines DB, Cuker A, Semple JW 2014 Presse Med View Researchers Clinical research
Platelet microparticles reprogram macrophage gene expression and function Laffont B, Corduan A, Rousseau M, Duchez AC, Lee CH, Boilard E, Provost P 2016 Thromb Haemost View Researchers Basic research
Quality of red blood cells washed using the ACP 215 cell processor: assessment of optimal pre- and postwash storage times and conditions Hansen A, Yi QL, Acker JP 2013 Transfusion View Researchers New or improved product or process
Research opportunities in optimizing storage of red blood cell products Wagner SJ, Glynn SA, Welniak LA, NHLBI Working Group on Strategies to Optimize Red Blood Cell Products 2014 Transfusion View Researchers Other
Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells Aslam R, Segel GB, Burack R, Spence SA, Speck ER, Guo L, Semple JW 2016 Br J Haematol View Researchers Basic research