Our Research Publications
Updated November 2023
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Title | Authors | Year | Journal | Link to Article | Intended Audience Sort descending | Purpose |
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Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization | McEneny-King A, Chelle P, Foster G, Keepanasseril A, Iorio A, Edginton AN | 2019 | J Pharmacokinet Pharmacodyn | View Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization | Researchers | Clinical research |
The Impact of Bacterial Biofilms in Transfusion Medicine | Ramirez-Arcos S | 2020 | Racing for the Surface | View The Impact of Bacterial Biofilms in Transfusion Medicine | Researchers | Basic research |
Optimizing the supply of whole blood-derived bioproducts through the combined implementation of cryopreservation and pathogen reduction technologies and practices: An overview | Bohonek M, Kutac D, Acker JP, Seghatchian J | 2020 | Transfus Apher Sci | View Optimizing the supply of whole blood-derived bioproducts through the combined implementation of cryopreservation and pathogen reduction technologies and practices: An overview | Researchers | New or improved product or process |
Sex-mismatched red blood cell transfusions and mortality: A systematic review and meta-analysis | Zeller MP, Rochwerg B, Jamula E, Li N, Hillis C, Acker JP, Runciman RJR, Lane SJ, Ahmed N, Arnold DM, Heddle NM | 2019 | Vox Sang | View Sex-mismatched red blood cell transfusions and mortality: A systematic review and meta-analysis | Researchers | Clinical research |
Cardiac donation after circulatory determination of death: protocol for a mixed-methods study of healthcare provider and public perceptions in Canada | Honarmand K, Ball I, Weiss M, Slessarev M, Sibbald R, Sarti A, Meade M, D'Aragon F, Chasse M, Basmaji J, Parsons Leigh J | 2020 | BMJ Open | View Cardiac donation after circulatory determination of death: protocol for a mixed-methods study of healthcare provider and public perceptions in Canada | Researchers | New or improved product or process |
Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives | William N, Acker JP | 2020 | Cryobiology | View Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives | Researchers | Basic research |
Opportunities for standardization of cold stored, low-titre group O WB products | Acker JP, Seghatchian J | 2020 | Transfus Apher Sci | View Opportunities for standardization of cold stored, low-titre group O WB products | Researchers | New or improved product or process |
Screening of Feijoa (Acca Sellowiana (O. Berg) Burret) Fruit Effect on Proliferation and Apoptosis using Bone Marrow derived Stem Cells Model | Rasekh H, Mahrabani D, Hosseini Farahi M, Masoumi S, Acker J | 2021 | Electron J Gen Med | View Screening of Feijoa (Acca Sellowiana (O. Berg) Burret) Fruit Effect on Proliferation and Apoptosis using Bone Marrow derived Stem Cells Model | Researchers | Basic research |
Using blood donors and solid organ transplant donors and recipients to estimate the seroprevalence of cytomegalovirus and Epstein–Barr virus in Canada: A cross-sectional study | Mabilangan C, Burton C, O'Brien S, Plitt S, Eurich DT, Preiksaitis J | 2020 | JAMMI | View Using blood donors and solid organ transplant donors and recipients to estimate the seroprevalence of cytomegalovirus and Epstein–Barr virus in Canada: A cross-sectional study | Researchers | Clinical research |
Determinants of the intention to participate in a programme of plasma donation for fractionation among men who have sex with men | Veillette-Bourbeau L, Otis J, Lewin A, Godin G, Germain M, Daunais-Laurin G, Lalonde F, Caruso J, Myhal G, Pronovost F | 2021 | Vox Sang | View Determinants of the intention to participate in a programme of plasma donation for fractionation among men who have sex with men | Researchers | MSM research |
Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia | Shen C, Liu M, Mackeigan DT, Chen ZY, Chen P, Karakas D, Li J, Norris PAA, Li J, Deng Y, Long C, Lai R, Ni H | 2021 | Arch Toxicol | View Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia | Researchers | Basic research |
Aspirin nonsensitivity in patients with vascular disease: Assessment by light transmission aggregometry (aspirin nonsensitivity in vascular patients) | Khan H, Zamzam A, Gallant RC, Syed MH, Rand ML, Ni H, Forbes TL, Al-Omran M, Qadura M | 2021 | Res Pract Thromb Haemost | View Aspirin nonsensitivity in patients with vascular disease: Assessment by light transmission aggregometry (aspirin nonsensitivity in vascular patients) | Researchers | Clinical research |
Resistance of SARS-CoV-2 beta and gamma variants to plasma collected from Canadian blood donors during the spring of 2020 | Drews SJ, Abe KT, Hu Q, Samson R, Gingras A-C, Colwill K, Rathod B, Wang J, Fazel-Zarandi M, Yi Q-L, Robinson A, Wood H, Tuite A, Fisman D, Evans DH, Lin Y-CJ, O'Brien SF | 2022 | Transfusion | View Resistance of SARS-CoV-2 beta and gamma variants to plasma collected from Canadian blood donors during the spring of 2020 | Researchers | Clinical research |
Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice | Eltringham-Smith LJ, Meixner SC, Pryzdial ELG, Sheffield WP | 2023 | Sci Rep | View Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice | Researchers | Basic research |
Closed system processing variables affect post-thaw quality characteristics of cryopreserved red cell concentrates | Howell A, Turner TR, Hansen A, Lautner LJ, Yi Q, Acker JP | 2022 | Transfusion | View Closed system processing variables affect post-thaw quality characteristics of cryopreserved red cell concentrates | Researchers | Basic research |
Development and validation of a sensitive flow cytometric method for determining CECs in RBC products | Li W, Acker JP | 2022 | Clin Chim Acta | View Development and validation of a sensitive flow cytometric method for determining CECs in RBC products | Researchers | New or improved product or process |
Minimal impact of anticoagulant on in vitro whole blood quality throughout a 35-day cold-storage regardless of leukoreduction timing | Schubert P, Culibrk B, Bhakta V, Closas T, Sheffield WP, Devine DV, McTaggart K | 2022 | Transfusion | View Minimal impact of anticoagulant on in vitro whole blood quality throughout a 35-day cold-storage regardless of leukoreduction timing | Researchers | Basic research |
Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke | Zhang Z, Shen C, Fang M, Han Y, Long C, Liu W, Yang M, Liu M, Zhang D, Cao Q, Chen X, Fang Y, Lu Q, Hou Z, Li Y, Liu Z, Lei X, Ni H, Lai R | 2022 | Cell Mol Life Sci | View Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke | Researchers | Basic research |
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium | Jimenez-Diaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gomez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martinez MS, Miller G, Rodriguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK | 2014 | PNAS | View (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium | Researchers | Basic research |
A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models | Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V | 2014 | J Thromb Thrombolysis | View A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models | Researchers | Basic research |
Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness | Arnold DM, Lauzier F, Rabbat C, Zytaruk N, Barlow Cash B, Clarke F, Heels-Ansdell D, Guyatt G, Walter SD, Davies A, Cook DJ, PROTECT Investigators on behalf of the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Clinical Trials Group | 2013 | Thromb Res | View Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness | Researchers | Clinical research |
Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol | English SW, Fergusson D, Chassé M, Turgeon A, Lauzier F, Griesdale D, Algird A, Kramer A, Tinmouth A, Lum C | 2016 | BMJ Open | View Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol | Researchers | Clinical research |
Comparative characterisation of the biofilm-production abilities of Staphylococcus epidermidis isolated from human skin and platelet concentrates | Taha M, Kohnen C, Mallya S, Kou Y, Zapata A, Ramirez-Arcos S | 2018 | J Med Microbiol | View Comparative characterisation of the biofilm-production abilities of Staphylococcus epidermidis isolated from human skin and platelet concentrates | Researchers | New or improved product or process |
Cytokine profiles in mouse models of experimental immune thrombocytopenia reveal a lack of inflammation and differences in response to intravenous immunoglobulin depending on the mouse strain | Leontyev D, Neschadim A, Branch DR | 2014 | Transfusion | View Cytokine profiles in mouse models of experimental immune thrombocytopenia reveal a lack of inflammation and differences in response to intravenous immunoglobulin depending on the mouse strain | Researchers | Basic research |
Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets | Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS | 2016 | Blood | View Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets | Researchers | Basic research |
Effect of blood donor characteristics on transfusion outcomes: a protocol for systematic review and meta-analysis | Chasse M, English S, McIntyre L, Knoll G, Shehata N, Forster A, Wilson K, van Walraven C, Tinmouth A, Fergusson D | 2014 | Syst Rev | View Effect of blood donor characteristics on transfusion outcomes: a protocol for systematic review and meta-analysis | Researchers | Clinical research |
Extracellular histones identified in crocodile blood inhibit in-vitro HIV-1 infection | Kozlowski HN, Lai ET, Havugimana PC, White C, Emili A, Sakac D, Binnington B, Neschadim A, McCarthy SD, Branch DR | 2016 | AIDS | View Extracellular histones identified in crocodile blood inhibit in-vitro HIV-1 infection | Researchers | Basic research |
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition | Roddick LA, Bhakta V, Sheffield W | 2013 | BMC Biochem | View Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition | Researchers | Basic research |
Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q | Qiu Y, Marquez-Curtis LA, Janowska-Wieczorek A | 2012 | Cytotherapy | View Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q | Researchers | Basic research |
Moonlighting glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is required for efficient hepatitis C virus and dengue virus infections in human Huh-7.5.1 cells | Raj M, Langley M, McArthur SJ, Jean F | 2017 | J Gen Virol | View Moonlighting glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is required for efficient hepatitis C virus and dengue virus infections in human Huh-7.5.1 cells | Researchers | Basic research |
Optimal Attenuation of Experimental Autoimmune Encephalomyelitis by Intravenous Immunoglobulin Requires an Intact Interleukin-11 Receptor | Figueiredo CA, Drohomyrecky PC, McCarthy SDS, Leontyev D, Ma X-Z, Branch DR, Dunn SE | 2014 | PLoS One | View Optimal Attenuation of Experimental Autoimmune Encephalomyelitis by Intravenous Immunoglobulin Requires an Intact Interleukin-11 Receptor | Researchers | Basic research |
Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin | Qadri SM, Donkor DA, Bhakta V, Eltringham-Smith LJ, Dwivedi DJ, Moore JC, Pepler L, Ivetic N, Nazi I, Fox-Robichaud AE, Liaw PC, Sheffield WP | 2016 | J Cell Mol Med | View Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin | Researchers | Basic research |
Platelets and platelet alloantigens: lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia | Vadasz B, Chen P, Yougbare I, Zdravic D, Li J, Li C, Carrim N, Ni H | 2015 | Genes Dis | View Platelets and platelet alloantigens: lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia | Researchers | Other |
Producing megakaryocytes from a human peripheral blood source | Ivetic N, Nazi I, Karim N, Clare R, Smith JW, Moore JC, Hope KJ, Kelton JG, Arnold DM | 2016 | Transfusion | View Producing megakaryocytes from a human peripheral blood source | Researchers | Basic research |
Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols | Rossi NAA, Constantinescu I, Kainthan RK, Brooks DE, Scott MD, Kizhakkedathu JN | 2010 | Biomaterials | View Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols | Researchers | Basic research |
Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias | Purohit MK, Chakka SK, Scovell I, Neschadim A, Bello AM, Salum N, Katsman Y, Bareau MC, Branch DR, Kotra LP | 2014 | Bioorg Med Chem | View Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias | Researchers | Basic research |
The clinical significance of platelet microparticle-associated microRNAs | Provost P | 2017 | Clin Chem Lab Med | View The clinical significance of platelet microparticle-associated microRNAs | Researchers | Basic research |
The maternal immune response to fetal platelet GPIb? causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies | Li C, Piran S, Chen P, Lang S, Zarpellon A, Jin JW, Zhu G, Reheman A, van der Wal DE, Simpson EK, Ni R, Gross PL, Ware J, Ruggeri ZM, Freedman J, Ni H | 2011 | J Clin Invest | View The maternal immune response to fetal platelet GPIb? causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies | Researchers | Basic research |
Thrombin a-chain: activation remnant or allosteric effector? | Carter IS, Vanden Hoek AL, Pryzdial EL, Macgillivray RT | 2010 | Thrombosis | View Thrombin a-chain: activation remnant or allosteric effector? | Researchers | Basic research |
Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection | Veljkovic V, Loiseau PM, Figadere B, Glisic S, Veljkovic N, Perovic VR, Cavanaugh DP, Branch DR | 2015 | F1000Res | View Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection | Researchers | Basic research |
Concentré de recherche : Un sur un million : un modèle pour gérer les réserves de sang rare | Blake J, Clarke G | 2019 | Blood.ca website | View Concentré de recherche : Un sur un million : un modèle pour gérer les réserves de sang rare | Researchers | Clinical research |
A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia | Ivetic N, Arnold D, Smith J, Huynh A, Kelton J, Nazy I | 2019 | Platelets | View A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia | Researchers | Basic research |
What Goes Up, Must Go Down? | Parker MJ | 2018 | Pediatr Crit Care Med | View What Goes Up, Must Go Down? | Researchers | Clinical research |
Extending the pre-processing holding time of whole blood beyond 48h reduces coagulation FVIII activity and immunoglobulin G content of recovered plasma | Sheffield WP, Bhakta V, Jenkins C | 2018 | Transfus Apher Sci | View Extending the pre-processing holding time of whole blood beyond 48h reduces coagulation FVIII activity and immunoglobulin G content of recovered plasma | Researchers | New or improved product or process |
High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT | Warkentin TE, Sheppard JI, Linkins L, Arnold DM, Nazy I | 2018 | Blood | View High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT | Researchers | New or improved product or process |
Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries | Iorio A, Stonebraker JS, Chambost H, Makris M, Coffin D, Herr C, Germini F, for the Data Demographics Committee of the World Federation of Hemophilia | 2019 | Ann Intern Med | View Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries | Researchers | Clinical research |
Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? | Levy JH, Ghadimi K, Faraoni D, van Diepen S, Levy B, Hotchkiss R, Connors JM, Iba T, Warkentin TE | 2019 | J Thromb Haemost | View Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? | Researchers | Clinical research |
Portrayal of umbilical cord blood research in the North American popular press: promise or hype? | Marcon AR, Allan D, Barber M, Murdosh B, Caulfield T | 2020 | Regen Med | View Portrayal of umbilical cord blood research in the North American popular press: promise or hype? | Researchers | Other |
Current techniques and the future of lung preservation | Lautner LJ, Freed DH, Nagendran J, Acker JP | 2020 | Cryobiology | View Current techniques and the future of lung preservation | Researchers | Basic research |
Extension of platelet shelf life with an improved bacterial testing algorithm | Ramirez-Arcos S, Evans S, McIntyre T, Pang C, Yi Q-L, DiFranco C, Goldman M | 2020 | Transfusion | View Extension of platelet shelf life with an improved bacterial testing algorithm | Researchers | New or improved product or process |