Our Funded Research Projects

Updated April 2024

Title Principal Investigator / Supervisor Program Project Start Date Sort ascending Project End Date Total $ Awarded
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: JAHAN, Suria
Graduate Fellowship Program 104000.0
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: McCARTHY, Stephen
Graduate Fellowship Program 96000.0
Investigation of pathophysiology, prevention and treatment of murine Transfusion Related Acute Lung Injury (TRALI) Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: McVEY, Mark
Graduate Fellowship Program 52000.0
Polyhemoglobin catalase superoxide dismutase carbonic anhydrase: a novel soluble biotherapeutic with no cardiac toxicity for hemorrhagic shock and other uses Principal Investigator: CHANG, Thomas

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 224520.0
University of Ottawa Centre for Transfusion Research Principal Investigator: TINMOUTH, Alan

Co-Investigator(s) / Trainee:
Program Support Award for Canadian Transfusion Medicine and Science Research Program 799887.8
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing major liver resection: a pilot randomized controlled trial Principal Investigator: KARANICOLAS, Paul

Co-Investigator(s) / Trainee: GUYATT, Gordon H. , CHAUDHURY, Prosanto K. , DIXON, Elijah , LIN, Yulia , McCLUSKEY, Stuart A. , PORTER, Geoffrey A. , TARSHIS, Jordan , WEI, Alice C.
Canadian Blood Services-CIHR Partnership Operating Grant Program 248319.0
Characterization of the hematopoietic reconstitution enhancing activity of osteoblasts derived from human mesenchymal stromal cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: CAMPBELL, Pearl , GARNIER, Alain
Canadian Blood Services-CIHR Partnership Operating Grant Program 320504.0
The Centre for Blood Research Principal Investigator: CONWAY, Ed

Co-Investigator(s) / Trainee:
Program Support Award for Canadian Transfusion Medicine and Science Research Program 776229.0
Understanding host mechanisms responsible for immune platelet destruction and thrombocytopenia Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 406003.0
McMaster Transfusion Research Program Principal Investigator: HEDDLE, Nancy

Co-Investigator(s) / Trainee:
Program Support Award for Canadian Transfusion Medicine and Science Research Program 833333.0
Design and implementation of circulatory oxygen therapeutics derived from human hemoglobin by improved systematic chemical coupling and cross-linking Principal Investigator: KLUGER, Ronald

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 192039.0
Role of Fc receptors in antibody-mediated immune suppression Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: BERNARDO REYES, Lidice
Postdoctoral Fellowship Program 106200.0
Antibodies to CD44 as a potential replacement for IVIg in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SEMPLE, John W., SHEFFIELD, William
Intramural Research Grant Program 300000.0
Residual risk of transfusion-transmitted cytomegalovirus infection: incidence and pathogenesis Principal Investigator: PREIKSAITIS, Jutta

Co-Investigator(s) / Trainee: O'BRIEN, Sheila F., FEARON, Margaret, NAHIRNIAK, Susan
Intramural Research Grant Program 260451.0
Characterization of the role of MSI2 in human hematopoietic stem cell self-renewal Principal Investigator: HOPE, Kristin

Co-Investigator(s) / Trainee: RENTAS, Stefan
Graduate Fellowship Program 100000.0
MRI guided focused ultrasound facilitated IVIg immunotherapy as a therapeutic approach for Alzheimer's disease Principal Investigator: AUBERT, Isabelle

Co-Investigator(s) / Trainee: DUBEY, Sonam
Graduate Fellowship Program 100000.0
Platelet microRNAs during storage under blood bank conditions Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: HITZLER, Walter
Canadian Blood Services-CIHR Partnership Operating Grant Program 349548.0
Small molecule inhibitors of phagocytosis as replacement therapy for IVIG Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P.
Canadian Blood Services-CIHR Partnership Operating Grant Program 230000.0
Transfusion of red cells in hematopoietic stem cell transplantation: The TRIST Study Principal Investigator: TAY, Jason

Co-Investigator(s) / Trainee: ALLAN, David S. , COYLE, Douglas A. , FERGUSSON, Dean A. , TINMOUTH, Alan T. , WALKER, Irwin R
Canadian Blood Services-CIHR Partnership Operating Grant Program 340817.0
Development of novel blood vessel and organ sealants for blood conservation in surgical practice Principal Investigator: BROOKS, Don

Co-Investigator(s) / Trainee: DU, Caigan , HSIANG, York N. , KIZHAKKEDATHU, Jayachandran N. , KO, Frank K.
Canadian Blood Services-CIHR Partnership Operating Grant Program 240996.0
The Canadian National Transplant Research Program: increasing donating and improving transplantation outcomes Principal Investigator: WEST, Lori

Co-Investigator(s) / Trainee:
Transplantation Research Program 250000.0
Improving the cryostorage of blood products using novel small molecule cryoprotectants Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: ACKER, Jason P. , ALLAN, David S.
Canadian Blood Services-CIHR Partnership Operating Grant Program 384180.0
Transfusion-related Epstein-Barr Virus (EBV) infection among allogeneic stem cell transplant pediatric recipients: A multicenter prospective cohort study (TREASuRE Study) Principal Investigator: TROTTIER, Helen

Co-Investigator(s) / Trainee: ALFIERI, Carolina , BUTEAU, Chantal , DUVAL, Michel , LACROIX, Jacques , ROBITAILLE, Nancy , SPINELLA, Philip , TUCCI, Marisa
Canadian Blood Services-CIHR Partnership Operating Grant Program 519766.0
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage Principal Investigator: HOLOVATI, Jelena

Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana
Graduate Fellowship Program 100000.0
Identification of protein biomarkers for red cell quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: CHEN, Deborah
Graduate Fellowship Program 100000.0
Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanisms of IVIG therapy Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: YOUGBARE, Issaka
Postdoctoral Fellowship Program 151800.0
Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: BRIARD, Jennie
Graduate Fellowship Program 96000.0
Transfusion requirements in cardiac surgery (TRICS II) Principal Investigator: SHEHATA, Nadine

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership New Investigator Program 300000.0
Studies on the development of biocompatible antimicrobial platelet storage devices Principal Investigator: BROOKS, Don

Co-Investigator(s) / Trainee: HADJESFANDIARI, Narges
Graduate Fellowship Program 96000.0
Role of skin disinfection and buffy coat platelet production on residual bacterial contamination in platelet concentrates and cord blood stem cells Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: TAHA, Mariam
Graduate Fellowship Program 92000.0
Towards the impact of protein synthesis in human platelets to transfusion medicine Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: BOSGOED, Christa
Graduate Fellowship Program 92000.0
The use of antibody-mediated immune suppression as a model in the development of a replacement for RhD prophylaxis in haemolytic disease of the fetus and newborn Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 620822.0