Our Funded Research Projects

Updated April 2024

Title Principal Investigator / Supervisor Program Project Start Date Project End Date Total $ Awarded
Mathematical modeling - comparing HIV risk between MSM donation strategies Principal Investigator: O'BRIEN, Sheila

Co-Investigator(s) / Trainee: GRÉGOIRE, Yves, SEED, Clive, CUSTER, Brian, STEELE, Whitney, DAVISON, Katy, PILLONEL, Josiane 		MSM Research Grant Program 18000.0
ACB and MSM - it's not an oxymoron: A research project that explores the importance of ACB people in MSM blood donation research Principal Investigator: DRYDEN, OmiSoore

Co-Investigator(s) / Trainee: LEE, Woo Jin Edward, NELSON, LaRon, MARSHALL, Zack, MBUAGBAW, Lawrence 		MSM Research Grant Program 410000.0
Estimating the probability of HIV risk in MSM donor policies through biobehavioural and mathematical modelling studies Principal Investigator: HART, Trevor

Co-Investigator(s) / Trainee: LAMBERT, Gilles, GRACE, Daniel, BAUER, Greta, MOORE, David, COX, Joseph, LACHOWSKY, Nathan, MISHRA, Sharmistha, BRENNAN, David, TAN, Darrell, SKAKOON-SPARLING, Shayna 		MSM Research Grant Program 452500.0
Awareness and understanding of apheresis plasma donation and effectiveness of alternative donor screening questions for diverse gbMSM and trans populations Principal Investigator: GAHAGAN, Jacqueline

Co-Investigator(s) / Trainee: HAW, Jennie, LACHOWSKY, Nathan, DRYDEN, OmiSoore, MANNING, Eli, FOSTER, Terrie, O'BRIEN, Sheila, HACHETTE, Todd, MULLOWNEY, Mike 		MSM Plasma Program 200500.0
Assessing the acceptability and feasibility of a plasma donation program for gbMSM in Montréal from the point of view of cis and trans gbMSM, volunteers from Héma-Québec, current donors, and plasma product recipients Principal Investigator: OTIS, Joanne

Co-Investigator(s) / Trainee: GERMAIN, Marc, HAW, Jennie, MONTEITH, Kenneth, MYHAL, Geneviève, PRESSEAU, Justin, PIRNAT, Bojan, LAPIERRE, Don 		MSM Plasma Program 390970.0
The Calgary Plasma Study: feasibility of implementing source plasma donation with alternative screening eligibility criteria for men who have sex with men Principal Investigator: PRESSEAU, Justin

Co-Investigator(s) / Trainee: GOLDMAN, Mindy, O'BRIEN, Sheila, MACPHERSON, Paul, OTIS, Joanne, FOSTER, Terrie, VESNAVER, Elisabeth, GERMAIN, Marc, ROSSER, Andrew, LAPIERRE, Don, HILL, Nolan 		MSM Plasma Program 399875.0
Assessing acceptability, understanding and effectiveness of alternative screening questions for current donors Principal Investigator: FISHER, William

Co-Investigator(s) / Trainee: HAW, Jennie, GOLDMAN, Mindy, FOSTER, Terrie, O'BRIEN, Sheila, HOFKIRCHNER, Alexander 		MSM Plasma Program 129400.0
Prospective observational study of organ deceased donor management in 3 ICUs - a pilot study (the DONATE pilot study) Principal Investigator: MEADE, Maureen

Co-Investigator(s) / Trainee: D'ARAGON, Frederick, RIBIC, Christine, SHARPE, Michael, BALL, Ian, WILLIAMSON, David, DHANANI, Sonny, HANNA, Steven 		Kenneth J. Fyke Award Program 89555.1
Developing a Canadian policy on the responsible use of umbilical cord blood for proven indications in regenerative therapy Principal Investigator: ALLAN, David

Co-Investigator(s) / Trainee: HUTTON, Brian, CAULFIELD, Timothy 		Kenneth J. Fyke Award Program 100000.0
Canadians’ attitudes and opinions regarding cardiac donation after cardiocirculatory death: A mixed-methods study Principal Investigator: BALL, Ian

Co-Investigator(s) / Trainee: WEISS, Matt, D'ARAGON, Fred, PARSONS LEIGH, Jenna, HONARMAND, Kimia, BASMAJI, John, SIBBALD, Robert 		Kenneth J. Fyke Award Program 95929.0
The pan-Canadian immunoglobulin database: Enabling utilization reporting and personalized treatment using data mining techniques for immunoglobulin Principal Investigator: LI, Na

Co-Investigator(s) / Trainee: DOWN, Douglas, CHIANG, Fei, LEE, Joon, HEDDLE, Nancy, ARNOLD, Donald, CALLUM, Jeannie, SIDHU, Davinder, BARTY, Rebecca 		Kenneth J. Fyke Award Program 100000.0
Evaluating transfusion medicine patterns of practice across GEMINI sites Principal Investigator: CALLUM, Jeannie

Co-Investigator(s) / Trainee: ARNOLD, Donald, VERMA, Amol, SRIVASTAVA, Siddhartha, CHENG, Calvino, ESMAIL, Tariq, DESVEAUX, Laura, TYRYSHKIN, Kathrin, KARKOUTI, Keyvan, LADHA, Karim, LI, Na, PAVENSKI, Katerina, PENDERGRAST, Jacob, PRESSEAU, Justin, SCHNEIDER, Henry, SHEHATA, Nadine, SHIH, Andrew, THIRUMURTHY, Harsha, BREHAUT, Jamie, RAZAK, Fahad, MCLCEARY, Nicola, ZUCKERMAN, Jesse 		Kenneth J. Fyke Award Program 98822.0
Legal and policy strategies to optimize organ donation in Alberta Principal Investigator: TOEWS, Maeghan

Co-Investigator(s) / Trainee: 		James Kreppner Fellowship Program 150000.0
Organ donation in Canada: Engaging with stakeholders and proposing solutions to current legal and ethical challenges Principal Investigator: GRUBEN, Vanessa

Co-Investigator(s) / Trainee: 		James Kreppner Fellowship Program 150000.0
COVID-19 vaccination refusal and access to transplantation: an ethical conundrum. A legal analysis and a qualitative study with key stakeholders Principal Investigator: FORTIN, Marie-Chantal

Co-Investigator(s) / Trainee: CHANDLER, Jennifer, GILL, Justin, GOLDBERG, Aviva, GRUBEN, Vanessa 		James Kreppner Award Program 49952.0
Determining potential policy solutions for normothermic regional perfusion in organ donation in Canada through analysis and resolution of two key ethical challenges Principal Investigator: WEIJER, Charles

Co-Investigator(s) / Trainee: BADENOCH, Heather, BASMAJI, John, BRAHMANIA, Mayur, CHANDLER, Jennifer, HEALEY, Andrew, LINGARD, Lorelei, MURPHY, Nicholas, OTT, Mary, SHEMIE, Sam, SKARO, Anton, SLESSAREV, Marat 		James Kreppner Award Program 50000.0
Canadian cord blood banking: Legal and policy responses Principal Investigator: CAULFIELD, Timothy

Co-Investigator(s) / Trainee: MURDOCH, Blake, MARCON, Alessandro 		James Kreppner Award Program 50000.0
Of skin, sperm, and blood: A comparative analysis of exemptions in Canadian human tissue legislation Principal Investigator: CATTAPAN, Alana

Co-Investigator(s) / Trainee: VON TIGERSTROM, Barbara, NELSON, Eric, DAWSON, Rosanne 		James Kreppner Award Program 43275.0
The role of stakeholder trust in OTDT policy change: public and professional attitudes to ante-mortem interventions in organ donation Principal Investigator: CHANDLER, Jennifer

Co-Investigator(s) / Trainee: McKAY, Lindsey 		James Kreppner Award Program 50000.0
A multifaceted intervention to optimize red blood cell transfusion practice in two provinces Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle 		Intramural Research Grant Program 332942.0
IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes Principal Investigator: NING, Shuoyan

Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer 		Intramural Research Grant Program 270352.1
Residual risk of transfusion-transmitted cytomegalovirus infection: incidence and pathogenesis Principal Investigator: PREIKSAITIS, Jutta

Co-Investigator(s) / Trainee: O'BRIEN, Sheila F., FEARON, Margaret, NAHIRNIAK, Susan 		Intramural Research Grant Program 260451.0
RBC hemolysis and cellular effector mechanisms (RHANCEM) Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, PENDERGRAST,Jacob, CALLUM, Jeannie, YI, Qilong 		Intramural Research Grant Program 399927.3
Optimization of monoclonal anti-erythrocyte antibodies for improved immunoprophylaxis in a murine model Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu 		Intramural Research Grant Program 400000.0
Modulation of biofilm formation, virulence, and antimicrobial resistance by Staphylococcus aureus during platelet storage Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: SAD, Subash, MAH, Thien-Fah 		Intramural Research Grant Program 323252.6
Elucidation of the mechanism of IVIG-associated hemolysis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: PENDERGRAST, Jacob , CSERTI-GAZDEWICH, Christine , SHEHATA, Nadine , PAVENSKI, Katerina , LAU, Wendy , CALLUM, Jeannie , LIN, Yulia , LIEBERMAN, Lani , HANNACH, Barbara 		Intramural Research Grant Program 393712.0
Improving blood product quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: MA, Hongshen, JOHNSON, James, D'ALESSANDRO, Angelo 		Intramural Research Grant Program 304462.0
Monovalent Fc receptor blockade using novel fusion proteins: The road towards an IVIg replacement Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SHEFFIELD, William, BRANCH, Donald 		Intramural Research Grant Program 400000.0
New cryosolution for stem cell-based therapeutics Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: BEN, Robert, HARPER, Marie-Ellen, CHAKRABORTY, Nilay 		Intramural Research Grant Program 180000.0
Defining the components of transfusable plasma that reduce bleeding Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward, NI, Heyu 		Intramural Research Grant Program 218230.0
Controlling coagulopathy and bleeding in a mouse model of hemorrhagic shock Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: NAZY, Ishac 		Intramural Research Grant Program 274854.0
Influence of eryptosis and storage on transfused red cell recovery in sepsis Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: BRANCH, Donald, LIAW, Patricia, HEDDLE, Nancy, QADRI, Syed 		Intramural Research Grant Program 283569.0
Enabling next generation hematopoietic-based therapeutics and manufacturing Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MCCOMB, Scott, JEZIERSKI, Anna, MAGALHAES, Ana, IQBAL, Umer 		Intramural Research Grant Program 300000.0
Biomarkers in patients with anemia-induced thrombocytopenic bleeding (BAIT): A pilot study Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: WEBERT, Kathryn, LIAW, Patricia, BERG, Tobias, HEDDLE, Nancy 		Intramural Research Grant Program 200000.0
Evaluating the role of donor characteristics and blood component manufacturing on the quality of red cell concentrates Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: BRANCH, Donald, CLARKE, Gwen, NAHIRNIAK, Susan 		Intramural Research Grant Program 398382.8
Assessing the impact of donor manufacturing characteristics on survival of transfused red blood cells Principal Investigator: TINMOUTH, Alan

Co-Investigator(s) / Trainee: ACKER, Jason, FERGUSSON, Dean, CHASSÉ, Michaël 		Intramural Research Grant Program 90935.0
A clinical comparison of cold-stored and room temperature-stored allogeneic platelet transfusions in bleeding adult cardiac surgery patients - A randomized multicentre pilot study (PLTS-1 study) Principal Investigator: BARTOSZKO, Justyna

Co-Investigator(s) / Trainee: CALLUM, Jeannie, DEVINE, Dana, KARKOUTI, Keyvan, KAHR, Walter, MCVEY, Mark, PEER, Miki, RAO, Vivek, ABRAHAMYAN, Lusine, LIEBERMAN, Lani, MEWHORT, Holly 		Intramural Research Grant Program 242617.0
TAD-POL (Transfusion-Associated-Dyspnea: Prospective observation and laboratory assessment) Principal Investigator: CSERTI-GAZDEWICH, Christine

Co-Investigator(s) / Trainee: BRANCH, Donald, LAZARUS, Alan, CALLUM, Jeannie, LIN, Yulia, PENDERGRAST, Jacob, LIEBERMAN, Lani, SHEHATA, Nadine, PAVENSKI, Katerina, SKEATE, Robert 		Intramural Research Grant Program 278027.5
Development of porcine equivalent RCC and plasma units for translatable ex vivo organ perfusion research Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: FREED, Darren 		Intramural Research Grant Program 121834.0
Fc receptor blockade in transfusion medicine Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu, GUPTA, Akash, SHEHATA, Nadine, KJELDSEN-KRAGH, Jens, NEWMAN, Peter J., CSERTI-GAZDEWICH, Christine, RAVETCH, Jeffery 		Intramural Research Grant Program 400000.0
Development of a small molecule cocktail for the expansion of cord blood stem cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: BLAKE, John, AUDET, Julie 		Intramural Research Grant Program 237600.0
PREMISE: Point-of-care hemoglobin accuracy and transfusion outcomes in non-cardiac surgery Principal Investigator: MARTEL, Guillaume

Co-Investigator(s) / Trainee: TINMOUTH, Alan, FERGUSSON, Dean, MCISAAC, Daniel, SHAW, Julie, RAMSAY, Tim, PRESSEAU, Justin, WHERRETT, Christopher, CARRIER, François-Martin, SEELY, Andrew, BRYSON, Gregory 		Intramural Research Grant Program 392974.0
Small molecule inhibitors of phagocytosis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi P. 		Intramural Research Grant Program 399130.0
Monoclonal antibodies with anti-D-like activity in the amelioration of murine immune thrombocytopenia (ITP) Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SEMPLE, John W., NI, Heyu 		Intramural Research Grant Program 400000.0
Plasma transfusion or plasma protein product infusion in a murine model of trauma Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward 		Intramural Research Grant Program 257414.8
Anti-RBC monoclonal antibodies as a replacement for IVIg and anti-D in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: BRANCH, Donald, DUNN, Shannon 		Intramural Research Grant Program 400000.0
Can pre-operative anemia be timely identified and optimized in patients awaiting primary arthroplasty surgery? A randomized clinical trial Principal Investigator: GRAMMATOPOULOS, George

Co-Investigator(s) / Trainee: FERGUSSON, Dean, RAMSAY, Tim, TINMOUTH, Alan, GAGNE, Sylvain, MACK, Johnathan, BELZILE, Etienne, BEALE, Paul, THAVORN, Kednapa, TOUCHIE, Donna, GERMAIN, Genevieve, LAROCHE, Vincent 		Intramural Research Grant Program 276081.0
Role of blood component manufacturing on microvesicle-induced transfusion-related immune modulation Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: HOLOVATI, Jelena, BRANCH, Donald, ZHANG, Haibo 		Intramural Research Grant Program 250660.0
Small molecule drug development of phagocytosis inhibitors Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P. 		Intramural Research Grant Program 428468.4
Translating novel clotting factor X function to treat thrombosis Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: MACVICAR, Brian, SHEFFIELD, William 		Intramural Research Grant Program 369052.0