Our Funded Research Projects

Updated April 2024

Title Principal Investigator / Supervisor Program Sort descending Project Start Date Project End Date Total $ Awarded
Improving the cryostorage of blood products using novel small molecule cryoprotectants Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: ACKER, Jason P. , ALLAN, David S.
Canadian Blood Services-CIHR Partnership Operating Grant Program 384180.0
Release, delivery and cell programming effects of platelet microparticles and microRNAs Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: BOILARD, Eric
Canadian Blood Services-CIHR Partnership Operating Grant Program 427422.0
Polymer-based manufacturing tolerogenic miRNA-based therapeutics Principal Investigator: SCOTT, Mark

Co-Investigator(s) / Trainee: HORWITZ, Marc S.
Canadian Blood Services-CIHR Partnership Operating Grant Program 491125.0
Small molecule inhibitors of phagocytosis as replacement therapy for IVIG Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P.
Canadian Blood Services-CIHR Partnership Operating Grant Program 230000.0
Microfluidic devices to measure the deformability of stored red blood cells Principal Investigator: MA, Hongshen

Co-Investigator(s) / Trainee: SCOTT, Mark D.
Canadian Blood Services-CIHR Partnership Operating Grant Program 398301.0
Aneurysmal SubArachnoid Hemorrhage - Red blood cell transfusion And outcome (SAHaRA): a pilot randomized controlled trial Principal Investigator: ENGLISH, Shane

Co-Investigator(s) / Trainee: McINTYRE, Lauralyn A. , ALGIRD, Almunder , BOUTIN, Amélie , CHASSE, Michael , DOWLATSHAHI, Dariush , FERGUSSON, Dean A. , GRIESDALE, Donald , KRAMER, Andreas H. , LAUZIER, François , LUM, Cheemun , MARSHALL, Shawn C. , PAGLIARELLO, Giuseppe , SINCLAIR, John , TINMOUTH, Alan T. , TURGEON, Alexis F.
Canadian Blood Services-CIHR Partnership Operating Grant Program 157172.0
Development of novel blood vessel and organ sealants for blood conservation in surgical practice Principal Investigator: BROOKS, Don

Co-Investigator(s) / Trainee: DU, Caigan , HSIANG, York N. , KIZHAKKEDATHU, Jayachandran N. , KO, Frank K.
Canadian Blood Services-CIHR Partnership Operating Grant Program 240996.0
Understanding transcriptional and epigenetic control by Gfi1b towards the development of a therapy for sickle cell disease Principal Investigator: TRUDEL, Marie

Co-Investigator(s) / Trainee: MOROY, Tarik
Canadian Blood Services-CIHR Partnership Operating Grant Program 453132.0
Myocardial Ischemia and Transfusion. The MINT rollover trial Principal Investigator: HEBERT, Paul

Co-Investigator(s) / Trainee: CARSON, Jeffrey L., DEVEREAUX, Philip J., EIKELBOOM, John W., FERGUSSON, Dean A., GOODMAN, Shaun G. , MCALISTER, Finlay A. , TINMOUTH, Alan T.
Canadian Blood Services-CIHR Partnership Operating Grant Program 140210.0
Platelet microRNAs during storage under blood bank conditions Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: HITZLER, Walter
Canadian Blood Services-CIHR Partnership Operating Grant Program 349548.0
Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPlba- and anti-GPllbllla-mediated thrombocytopenia? Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 378529.0
Fetal and neonatal alloimmune thrombocytopenia: novel mechanisms and therapeutic approaches Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 471393.0
Transfusion of red cells in hematopoietic stem cell transplantation: The TRIST Study Principal Investigator: TAY, Jason

Co-Investigator(s) / Trainee: ALLAN, David S. , COYLE, Douglas A. , FERGUSSON, Dean A. , TINMOUTH, Alan T. , WALKER, Irwin R
Canadian Blood Services-CIHR Partnership Operating Grant Program 340817.0
Mechanisms of antibody-independent transfusion-related acute lung injury (TRALI) Principal Investigator: KUEBLER, Wolfgang

Co-Investigator(s) / Trainee: SEMPLE, John W.
Canadian Blood Services-CIHR Partnership Operating Grant Program 328712.0
Novel mechanisms of platelet aggregation: Roles of non-classical beta-3 integrin ligands and fibronectin in thrombosis and hemostasis Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 398871.0
Transfusion-related Epstein-Barr Virus (EBV) infection among allogeneic stem cell transplant pediatric recipients: A multicenter prospective cohort study (TREASuRE Study) Principal Investigator: TROTTIER, Helen

Co-Investigator(s) / Trainee: ALFIERI, Carolina , BUTEAU, Chantal , DUVAL, Michel , LACROIX, Jacques , ROBITAILLE, Nancy , SPINELLA, Philip , TUCCI, Marisa
Canadian Blood Services-CIHR Partnership Operating Grant Program 519766.0
Short and long-term clinical effects of blood donor characteristics in transfusion recipients Principal Investigator: FERGUSSON, Dean

Co-Investigator(s) / Trainee: ACKER, Jason P., CHASSÉ, Michael, ENGLISH, Shane, FORSTER, Alan, KNOLL, Greg, McINTYRE, Lauralyn A., SHEHATA, Nadine , van WALRAVEN, Carl, WILSON, Kumanan , TINMOUTH, Alan T.
Canadian Blood Services-CIHR Partnership Operating Grant Program 103806.0
Expanding treatment options for inflammatory bowel disease: A novel mechanism of antibody-based immunotherapy Principal Investigator: SLY, Laura

Co-Investigator(s) / Trainee: HORWITZ, Marc, BRESSLER, Brian, RASSEKH, Rod, TURVEY, Stuart
Canadian Blood Services-CIHR Partnership Operating Grant Program 408540.6
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing major liver resection: a pilot randomized controlled trial Principal Investigator: KARANICOLAS, Paul

Co-Investigator(s) / Trainee: GUYATT, Gordon H. , CHAUDHURY, Prosanto K. , DIXON, Elijah , LIN, Yulia , McCLUSKEY, Stuart A. , PORTER, Geoffrey A. , TARSHIS, Jordan , WEI, Alice C.
Canadian Blood Services-CIHR Partnership Operating Grant Program 248319.0
Exploratory analyses to determine if method of donor blood processing affects outcome in transfused recipients Principal Investigator: HEDDLE, Nancy

Co-Investigator(s) / Trainee: ACKER, Jason P. , ARNOLD, Donald M. , COOK, Richard J. , EIKELBOOM, John W. , O'BRIEN, Sheila F. , WEBERT, Kathryn E.
Canadian Blood Services-CIHR Partnership Operating Grant Program 159878.0
Understanding host mechanisms responsible for immune platelet destruction and thrombocytopenia Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program 406003.0
Examining the relationship between repeated blood donations in female donors on maternal/neonatal outcomes: a cohort study Principal Investigator: TINMOUTH, Alan

Co-Investigator(s) / Trainee: CHASSE, Michael, FERGUSSON, Dean A., GOLDMAN, Mindy R., O'BRIEN, Sheila F., SPRAGUE, Ann, van WALRAVEN, Carl, WALKER, Mark C., WILSON, Kumanan
Canadian Blood Services-CIHR Partnership Operating Grant Program 135657.0
Leveraging equity-focused implementation science to evaluate and support the re-integration of men who have sex with men into the blood donation system Principal Investigator: GOLDMAN, Mindy

Co-Investigator(s) / Trainee: VESNAVER, Elisabeth
CIHR Health System Impact Fellowship 108500.0
Process evaluation of the Canadian Blood Services' cord blood bank: managerial and donor perspectives Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: HAW, Jennie
CIHR Health System Impact Fellowship 46500.0
Options for increasing plasma supply in Canada: A health economic preference and modelling study Principal Investigator: HOLLOWAY, Kelly

Co-Investigator(s) / Trainee: KENNEDY, Kevin
CIHR Health System Impact Fellowship 108500.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: LAU, Wendy

Co-Investigator(s) / Trainee: TORDON, Bryan
Elianna Saidenberg Transfusion Medicine Traineeship Award 210000.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: LAU, Wendy

Co-Investigator(s) / Trainee: VANDERMEULEN, Heather
Elianna Saidenberg Transfusion Medicine Traineeship Award 210000.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: SHIH, Andrew

Co-Investigator(s) / Trainee: TAPLEY, Laura
Elianna Saidenberg Transfusion Medicine Traineeship Award 105000.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: ZELLER, Michelle

Co-Investigator(s) / Trainee: GABARIN, Nadia
Elianna Saidenberg Transfusion Medicine Traineeship Award 210000.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: LIN, Yulia

Co-Investigator(s) / Trainee: ARYA, Sumedha
Elianna Saidenberg Transfusion Medicine Traineeship Award 210000.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: LIN, Yulia

Co-Investigator(s) / Trainee: ROTIN, Lianne
Elianna Saidenberg Transfusion Medicine Traineeship Award 210000.0
Elianna Saidenberg Transfusion Medicine Trainee Principal Investigator: LIN, Yulia

Co-Investigator(s) / Trainee: RAZA, Sheharyar
Elianna Saidenberg Transfusion Medicine Traineeship Award 210000.0
CD71 Erythroid Cells, RBC Clearance and Sepsis in Donor - Recipient Sex- Mismatched Transfusion Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: LI, Wenhui
Graduate Fellowship Program 70000.0
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: JAHAN, Suria
Graduate Fellowship Program 104000.0
Synthesis of carbohydrate derivatives for the improvement of red blood cell storage Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: MEYER, Julia
Graduate Fellowship Program 79500.0
Transcriptome analyses of Staphylococcus aureus grown in platelet concentrates with focus on virulence Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: DA SILVA PAREDES, Carina
Graduate Fellowship Program 122000.0
Fc receptor blockade related to fetal and neonatal alloimmune thrombocytopenia Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: TAWHIDI, Zoya
Graduate Fellowship Program 70000.0
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: McCARTHY, Stephen
Graduate Fellowship Program 96000.0
Investigating the mechanism of anti-CD44 antibody amelioration of IVIg-treatable disease Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NORRIS, Peter
Graduate Fellowship Program 112333.3
Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: BRIARD, Jennie
Graduate Fellowship Program 96000.0
Perioperative transfusion threshold : A population-based observational study Principal Investigator: FERGUSSON, Dean

Co-Investigator(s) / Trainee: VERRET, Michael
Graduate Fellowship Program 52000.0
Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: TONG, Tik Nga (Cindy)
Graduate Fellowship Program 52000.0
Investigating a new class of small molecule ice recrystallization inhibitors for red blood cell cryopreservation Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: AMPAW, Anna
Graduate Fellowship Program 112333.3
Identification of protein biomarkers for red cell quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: CHEN, Deborah
Graduate Fellowship Program 100000.0
Donor factors and product quality Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: YAZDANBAKHSH, Mahsa
Graduate Fellowship Program 122000.0
Recombinant Fc multimers to replace IVIG Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: LEWIS, Bonnie
Graduate Fellowship Program 104000.0
Evaluation and improvement of cold stored platelets Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: ZHAO, Hanqi (Wayne)
Graduate Fellowship Program 112333.3
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage Principal Investigator: HOLOVATI, Jelena

Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana
Graduate Fellowship Program 100000.0
Mechanisms of anti-αIIb mediated miscarriage in fetal and neonatal alloimmune thrombocytopenia Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: CHEN, Zi Yan
Graduate Fellowship Program 52000.0
Study of the mechanisms implicated in platelets microparticle internalization by blood cells Principal Investigator: BOILARD, Eric

Co-Investigator(s) / Trainee: MARCOUX, Genevieve
Graduate Fellowship Program 104000.0