Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
A method to measure permeability of red blood cell membrane to water and solutes using intrinsic fluorescence Zhurova M, Olivieri A, Holt A, Acker JP 2014 Clin Chim Acta View Researchers Basic research
A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V 2014 J Thromb Thrombolysis View Researchers Basic research
Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness Arnold DM, Lauzier F, Rabbat C, Zytaruk N, Barlow Cash B, Clarke F, Heels-Ansdell D, Guyatt G, Walter SD, Davies A, Cook DJ, PROTECT Investigators on behalf of the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Clinical Trials Group 2013 Thromb Res View Researchers Clinical research
Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol English SW, Fergusson D, Chassé M, Turgeon A, Lauzier F, Griesdale D, Algird A, Kramer A, Tinmouth A, Lum C 2016 BMJ Open View Researchers Clinical research
Comparative characterisation of the biofilm-production abilities of Staphylococcus epidermidis isolated from human skin and platelet concentrates Taha M, Kohnen C, Mallya S, Kou Y, Zapata A, Ramirez-Arcos S 2018 J Med Microbiol View Researchers New or improved product or process
Cytokine profiles in mouse models of experimental immune thrombocytopenia reveal a lack of inflammation and differences in response to intravenous immunoglobulin depending on the mouse strain Leontyev D, Neschadim A, Branch DR 2014 Transfusion View Researchers Basic research
Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS 2016 Blood View Researchers Basic research
Effect of blood donor characteristics on transfusion outcomes: a protocol for systematic review and meta-analysis Chasse M, English S, McIntyre L, Knoll G, Shehata N, Forster A, Wilson K, van Walraven C, Tinmouth A, Fergusson D 2014 Syst Rev View Researchers Clinical research
Extracellular histones identified in crocodile blood inhibit in-vitro HIV-1 infection Kozlowski HN, Lai ET, Havugimana PC, White C, Emili A, Sakac D, Binnington B, Neschadim A, McCarthy SD, Branch DR 2016 AIDS View Researchers Basic research
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Roddick LA, Bhakta V, Sheffield W 2013 BMC Biochem View Researchers Basic research
Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q Qiu Y, Marquez-Curtis LA, Janowska-Wieczorek A 2012 Cytotherapy View Researchers Basic research
Moonlighting glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is required for efficient hepatitis C virus and dengue virus infections in human Huh-7.5.1 cells Raj M, Langley M, McArthur SJ, Jean F 2017 J Gen Virol View Researchers Basic research
Optimal Attenuation of Experimental Autoimmune Encephalomyelitis by Intravenous Immunoglobulin Requires an Intact Interleukin-11 Receptor Figueiredo CA, Drohomyrecky PC, McCarthy SDS, Leontyev D, Ma X-Z, Branch DR, Dunn SE 2014 PLoS One View Researchers Basic research
Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin Qadri SM, Donkor DA, Bhakta V, Eltringham-Smith LJ, Dwivedi DJ, Moore JC, Pepler L, Ivetic N, Nazi I, Fox-Robichaud AE, Liaw PC, Sheffield WP 2016 J Cell Mol Med View Researchers Basic research
Platelets and platelet alloantigens: lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia Vadasz B, Chen P, Yougbare I, Zdravic D, Li J, Li C, Carrim N, Ni H 2015 Genes Dis View Researchers Other
Producing megakaryocytes from a human peripheral blood source Ivetic N, Nazi I, Karim N, Clare R, Smith JW, Moore JC, Hope KJ, Kelton JG, Arnold DM 2016 Transfusion View Researchers Basic research
Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols Rossi NAA, Constantinescu I, Kainthan RK, Brooks DE, Scott MD, Kizhakkedathu JN 2010 Biomaterials View Researchers Basic research
Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias Purohit MK, Chakka SK, Scovell I, Neschadim A, Bello AM, Salum N, Katsman Y, Bareau MC, Branch DR, Kotra LP 2014 Bioorg Med Chem View Researchers Basic research
The clinical significance of platelet microparticle-associated microRNAs Provost P 2017 Clin Chem Lab Med View Researchers Basic research
The maternal immune response to fetal platelet GPIb? causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies Li C, Piran S, Chen P, Lang S, Zarpellon A, Jin JW, Zhu G, Reheman A, van der Wal DE, Simpson EK, Ni R, Gross PL, Ware J, Ruggeri ZM, Freedman J, Ni H 2011 J Clin Invest View Researchers Basic research
Thrombin a-chain: activation remnant or allosteric effector? Carter IS, Vanden Hoek AL, Pryzdial EL, Macgillivray RT 2010 Thrombosis View Researchers Basic research
Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection Veljkovic V, Loiseau PM, Figadere B, Glisic S, Veljkovic N, Perovic VR, Cavanaugh DP, Branch DR 2015 F1000Res View Researchers Basic research
Concentré de recherche : Un sur un million : un modèle pour gérer les réserves de sang rare Blake J, Clarke G 2019 Blood.ca website View Researchers Clinical research
A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia Ivetic N, Arnold D, Smith J, Huynh A, Kelton J, Nazy I 2019 Platelets View Researchers Basic research
What Goes Up, Must Go Down? Parker MJ 2018 Pediatr Crit Care Med View Researchers Clinical research
Extending the pre-processing holding time of whole blood beyond 48h reduces coagulation FVIII activity and immunoglobulin G content of recovered plasma Sheffield WP, Bhakta V, Jenkins C 2018 Transfus Apher Sci View Researchers New or improved product or process
High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT Warkentin TE, Sheppard JI, Linkins L, Arnold DM, Nazy I 2018 Blood View Researchers New or improved product or process
Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries Iorio A, Stonebraker JS, Chambost H, Makris M, Coffin D, Herr C, Germini F, for the Data Demographics Committee of the World Federation of Hemophilia 2019 Ann Intern Med View Researchers Clinical research
Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? Levy JH, Ghadimi K, Faraoni D, van Diepen S, Levy B, Hotchkiss R, Connors JM, Iba T, Warkentin TE 2019 J Thromb Haemost View Researchers Clinical research
Portrayal of umbilical cord blood research in the North American popular press: promise or hype? Marcon AR, Allan D, Barber M, Murdosh B, Caulfield T 2020 Regen Med View Researchers Other
Current techniques and the future of lung preservation Lautner LJ, Freed DH, Nagendran J, Acker JP 2020 Cryobiology View Researchers Basic research
Extension of platelet shelf life with an improved bacterial testing algorithm Ramirez-Arcos S, Evans S, McIntyre T, Pang C, Yi Q-L, DiFranco C, Goldman M 2020 Transfusion View Researchers New or improved product or process
Screening of Feijoa (Acca Sellowiana (O. Berg) Burret) Fruit Effect on Proliferation and Apoptosis using Bone Marrow derived Stem Cells Model Rasekh H, Mahrabani D, Hosseini Farahi M, Masoumi S, Acker J 2021 Electron J Gen Med View Researchers Basic research
Using blood donors and solid organ transplant donors and recipients to estimate the seroprevalence of cytomegalovirus and Epstein–Barr virus in Canada: A cross-sectional study Mabilangan C, Burton C, O'Brien S, Plitt S, Eurich DT, Preiksaitis J 2020 JAMMI View Researchers Clinical research
Determinants of the intention to participate in a programme of plasma donation for fractionation among men who have sex with men Veillette-Bourbeau L, Otis J, Lewin A, Godin G, Germain M, Daunais-Laurin G, Lalonde F, Caruso J, Myhal G, Pronovost F 2021 Vox Sang View Researchers MSM research
Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia Shen C, Liu M, Mackeigan DT, Chen ZY, Chen P, Karakas D, Li J, Norris PAA, Li J, Deng Y, Long C, Lai R, Ni H 2021 Arch Toxicol View Researchers Basic research
Aspirin nonsensitivity in patients with vascular disease: Assessment by light transmission aggregometry (aspirin nonsensitivity in vascular patients) Khan H, Zamzam A, Gallant RC, Syed MH, Rand ML, Ni H, Forbes TL, Al-Omran M, Qadura M 2021 Res Pract Thromb Haemost View Researchers Clinical research
Resistance of SARS-CoV-2 beta and gamma variants to plasma collected from Canadian blood donors during the spring of 2020 Drews SJ, Abe KT, Hu Q, Samson R, Gingras A-C, Colwill K, Rathod B, Wang J, Fazel-Zarandi M, Yi Q-L, Robinson A, Wood H, Tuite A, Fisman D, Evans DH, Lin Y-CJ, O'Brien SF 2022 Transfusion View Researchers Clinical research
Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice Eltringham-Smith LJ, Meixner SC, Pryzdial ELG, Sheffield WP 2023 Sci Rep View Researchers Basic research
Closed system processing variables affect post-thaw quality characteristics of cryopreserved red cell concentrates Howell A, Turner TR, Hansen A, Lautner LJ, Yi Q, Acker JP 2022 Transfusion View Researchers Basic research
Development and validation of a sensitive flow cytometric method for determining CECs in RBC products Li W, Acker JP 2022 Clin Chim Acta View Researchers New or improved product or process
Minimal impact of anticoagulant on in vitro whole blood quality throughout a 35-day cold-storage regardless of leukoreduction timing Schubert P, Culibrk B, Bhakta V, Closas T, Sheffield WP, Devine DV, McTaggart K 2022 Transfusion View Researchers Basic research
Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke Zhang Z, Shen C, Fang M, Han Y, Long C, Liu W, Yang M, Liu M, Zhang D, Cao Q, Chen X, Fang Y, Lu Q, Hou Z, Li Y, Liu Z, Lei X, Ni H, Lai R 2022 Cell Mol Life Sci View Researchers Basic research
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium Jimenez-Diaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gomez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martinez MS, Miller G, Rodriguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK 2014 PNAS View Researchers Basic research
Antibody-Mediated Immune Suppression of Erythrocyte Alloimmunization Can Occur Independently from Red Cell Clearance or Epitope Masking in a Murine Model Yu H, Stowell SR, Bernardo L, Hendrickson JE, Zimring JC, Amash A, Uchikawa M, Lazarus AH 2014 J Immunol View Researchers Basic research
Bacterial neuraminidase-mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure Qadri SM, Donkor DA, Nazy I, Branch DR, Sheffield WP 2018 Eur J Haematol View Researchers Basic research
Characterization of the growth modulatory activities of osteoblast conditioned media on cord blood progenitor cells Abu-Khader A, Pasha R, Ward GCD, Boisjoli G, Pineault N 2016 Cytotechnology View Researchers Basic research
Concentré de recherche: Cellules tueuses naturelles : quand les cellule perdent le nord! Ni H 2017 Blood.ca website View Researchers Basic research
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia Li J, van der Wal DE, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B, Carrim N, Grozovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai Z-m, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM, Ni H 2015 Nat Commun View Researchers Basic research
Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol Lalu MM, Moher D, Marshall J, Fergusson D, Mei SH, Macleod M, Griffin G, Turgeon AF, Rudnicki M, Fishman J, Avey MT, Skidmore B, Grimshaw JM, Stewart DJ, Singh K, McIntyre L 2014 Syst Rev View Researchers Clinical research