Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Risk of acute kidney injury in patients randomized to a restrictive versus liberal approach to red blood cell transfusion in cardiac surgery: a substudy protocol of the transfusion requirements in cardiac surgery III noninferiority trial Garg AX, Shehata N, McGuinness S, Whitlock R, Fergusson D, Wald R, Parikh C, Bagshaw SM, Khanykin B, Gregory A, Syed S, Hare GMT, Cuerden MS, Thorpe KE, Hall J, Verma S, Roshanov PS, Sontrop JM, Mazer CD 2018 Can J Kidney Health Dis View Researchers Clinical research
Small-molecule ice recrystallization inhibitors improve the post-thaw function of hematopoietic stem and progenitor cells Briard JG, Jahan S, Chandran P, Allan D, Pineault N, Ben RN 2016 ACS Omega View Researchers Basic research
T Regulatory Cells and Dendritic Cells Protect Against Transfusion-Related Acute Lung Injury via IL-10 Kapur R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER 2017 Blood View Researchers Basic research
The Fanconi Anemia Group C Protein Interacts with Uncoordinated 5A and Delays Apoptosis Huang F, Ben Aissa M, Magron A, Huard CC, Godin C, Levesque G, Carreau M 2014 PLoS One View Researchers Basic research
The role of glycosphingolipids in HIV/AIDS Lingwood CA, Branch DR 2011 Discov Med View Researchers Basic research
Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model Brinc D, Le-Tien H, Crow AR, Semple JW, Freedman J, Lazarus AH 2010 Transfusion View Researchers Basic research
Using Raman spectroscopy to assess hemoglobin oxygenation in red blood cell concentrate: an objective proxy for morphological index to gauge the quality of stored blood? Atkins CG, Schulze HG, Chen D, Devine DV, Blades MW, Turner RF 2017 Analyst View Researchers New or improved product or process
Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties Abu-Khader A, Law KW, Jahan S, Manesia JK, Pasha R, Hovey O, Pineault N 2019 Stem Cells View Researchers Basic research
Initial flow cytometric evaluation of the Clearllab lymphoid screen Hedley BD, Cheng G, Luider J, Kern W, Lozanski G, Chin-Yee I, Lowes LE, Keeney M, Careaga D, Magari R, Tejidor L 2018 Cytometry B Clin Cytom View Researchers Basic research
Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia: a systematic review Kjaer M, Bertrand G, Bakchoul T, Massey E, Baker JM, Lieberman L, Tanael S, Greinacher A, Murphy MF, Arnold DM, Baidya S, Bussel J, Hume H, Kaplan C, Oepkes D, Ryan G, Savoia H, Shehata N, Kjeldsen-Kragh J, International Collaboration for Transfusion Medicine Guidelines 2018 Vox Sang View Researchers Clinical research
Ultraviolet-based pathogen inactivation systems: untangling the molecular targets activated in platelets Schubert P, Johnson L, Marks DC, Devine DV 2018 Front Med View Researchers Basic research
Intravenous immunoglobulin (IVIg) or IVIg-treated macrophages reduce DSS-induced colitis by inducing macrophage IL-10 production Kozicky LK, Menzies SC, Hotte N, Madsen KL, Sly LM 2019 Eur J Immunol View Researchers Basic research
Platelet rich plasma in treatment of musculoskeletal pathologies Mehrabani D, Seghatchian J, Acker JP 2019 Transfus Apher Sci View Researchers Basic research
Aging, chronic inflammation, and platelet hyperactivity Ma W, Karakas D, Chen ZY, Ni H 2020 Ann Blood View Researchers Basic research
A crosswalk tabular review on methods and outcomes from randomized clinical trials using pathogen reduced platelets Rebulla P, Garban F, van der Meer PF, Heddle NM, McCullough J 2020 Transfusion View Researchers Clinical research
Update on newer approaches to prevent or treat COVID-19 infection: What we all need the most right now!! Seghatchian J, Acker JP, Putter JS 2020 Transfus Apher Sci View Researchers New or improved product or process
Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K 2021 J Thromb Haemost View Researchers Clinical research
Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis Siemieniuk RA, Bartoszko JJ, Díaz Martinez JP, Kum E, Qasim A, Zeraatkar D, Izcovich A, Mangala S, Ge L, Han MA, Agoritsas T, Arnold D, Ávila C, Chu DK, Couban R, Cusano E, Darzi AJ, Devji T, Foroutan F, Ghadimi M, Khamis A, Lamontagne F, Loeb M, Miroshnychenko A, Motaghi S, Murthy S, Mustafa RA, Rada G, Rochwerg B, Switzer C, Vandvik PO, Vernooij RW, Wang Y, Yao L, Guyatt GH, Brignardello-Petersen R 2021 BMJ View Researchers Clinical research
Hemolysis after high-dose intravenous immunoglobulin: An under-appreciated sequelae Branch DR, Almizraq RJ, Bussel JB 2022 Am J Hematol View Researchers Basic research
Prolonged Blood Storage and Risk of Posttransfusion Acute Kidney Injury Adegboye J, Sapatnekar S, Mascha EJ, Shah K, Lioudis M, Essber H, Cohen B, Rivas E, Heddle NM, Eikelboom JW, Ellis MH, Sharon Y, Sinha R, Kurz A, Sessler DI 2022 Anesthesiology View Researchers Clinical research
A critical contribution in a time of crisis: Examining motivations and deterrents to COVID-19 convalescent plasma donation and future donation intentions among prospective Canadian donors Holloway K, Campbell C, Ali R, Huyer LD, Hart D, Haw J, Brennenstuhl S, Grundy Q 2022 Transfus Med View Researchers Ethical, legal & social implications research
Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude Li M, Tang X, Liao Z, Shen C, Cheng R, Fang M, Wang G, Li Y, Tang S, Xie L, Zhang Z, Kamau PM, Mwangi J, Lu Q, Li Y, Wang Y, MacKeigan DT, Cerenzia EG, Ni H, Lai R 2022 Blood View Researchers Basic research
RE: A better normal in Canada will need a better detection system for emerging and re-emerging respiratory pathogens O'Brien S, Goldman M, Drews S 2022 CMAJ View Researchers Clinical research
Clinical Outcomes of Umbilical Cord Blood Transplantation Using Ex Vivo Expansion: A Systematic Review and Meta-Analysis of Controlled Studies Saiyin T, Kirkham AM, Bailey AJM, Shorr R, Pineault N, Maganti HB, Allan DS 2023 Transplant Cell Ther View Researchers Clinical research
Contamination of platelet concentrates with Staphylococcus aureus induces significant modulations in platelet functionality Yousuf B, Pasha R, Pineault N, Ramirez-Arcos S 2022 Vox Sang View Researchers Basic research
A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level 3 biocontainment Harrison AL, Henry S, Mahfoud R, Manis A, Albertini A, Gaudin Y, Lingwood CA, Branch DR 2011 Future Virol View Researchers Basic research
Cell-based therapy using umbilical cord blood for novel indications in regenerative therapy and immune modulation: an updated systematic scoping review of the literature Rizk M, Aziz J, Shorr R, Allan DS 2017 Biol Blood Marrow Transplant View Researchers Clinical research
Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study Linkins LA, Bates SM, Lee AY, Heddle NM, Wang G, Warkentin TE 2015 Blood View Researchers Clinical research
Early gamma-irradiation and subsequent storage of red cells in SAG?M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress?induced apoptotic cell death Qadri S, Chen D, Schubert P, Devine D, Sheffield W 2017 Vox Sang View Researchers Basic research
Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity Bhakta V, Gierczak RF, Sheffield WP 2013 J Biotechnol View Researchers Basic research
How do I interpret a confidence interval? O'Brien SF, Yi QL 2016 Transfusion View Researchers Other
Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells Ratajczak MZ, Kim C, Ratajczak J, Janowska-Wieczorek A 2013 Complement Therapeutics View Researchers Basic research
Large scale studies assessing anti-factor VIII antibody development in previously untreated haemophilia A: what has been learned, what to believe and how to learn more Iorio A, Fischer K, Makris M 2017 Br J Haematol View Researchers Clinical research
Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors Dumont N, Boyer L, Emond H, Saltik BC, Pasha R, Bazin R, Mantovani D, Roy DC, Pineault N 2014 Exp Hematol View Researchers Basic research
Peripheral blood monocyte-derived chemokine blockade prevents murine antibody-mediated transfusion-related acute lung injury (TRALI) McKenzie CG, Kim M, Singh TK, Milev Y, Freedman J, Semple JW 2014 Blood View Researchers Basic research
Rationale and Design of the Informing Fresh versus Old Red Cell Management (INFORM) Trial: An International Pragmatic Randomized Trial Eikelboom JW, Cook RJ, Barty R, Liu Y, Arnold DM, Crowther MA, Devereaux PJ, Ellis M, Figueroa P, Gallus A, Hirsh J, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warkentin TE, Webert KE, Heddle NM 2016 Transfus Med Rev View Researchers Clinical research
Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality Almizraq R, Tchir JD, Holovati JL, Acker JP 2013 Transfusion View Researchers Basic research
The M358R variant of α1-proteinase inhibitor inhibits coagulation factor VIIa Sheffield WP, Bhakta V 2016 Biochem Biophys Res Commun View Researchers Basic research
Therapeutic cells via functional modification: Influence of molecular properties of polymer grafts on in vivo circulation, clearance, immunogenicity and antigen protection Chapanian R, Constantinescu I, Medvedev N, Scott MD, Brooks DE 2013 Biomacromolecules View Researchers Basic research
Managing antithrombotic therapy in immune thrombocytopenia: development of the TH2 risk assessment score Balitsky AK, Kelton JG, Arnold DM 2018 Blood View Researchers New or improved product or process
The first case of severe acute hemolytic transfusion reaction caused by anti-Sc2 Lemay A-S, Tong TN, Branch DR, Huang M, Sumner C, Oldfield L, Hawes J, Cserti-Gazdewich CM, Lau W 2018 Transfusion View Researchers Clinical research
Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial Pai M, Adhikari NKJ, Ostermann M, Heels-Ansdell D, Douketis JD, Skrobik Y, Qushmaq I, Meade M, Guyatt G, Geerts W, Walsh MW, Crowther MA, Friedrich JO, Burry L, Bellomo R, Brandao da Silva N, Costa Filho R, Cox MJ, Alves Silva S, Cook DJ, on behalf of the PROTECT Investigators 2018 PLoS One View Researchers Clinical research
rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and Fc?Rs Spirig R, Campbell IK, Koernig S, Chen C-G, Lewis BJB, Butcher R, Muir I, Taylor S, Chia J, Leong D, Simmonds J, Scotney P, Schmidt P, Fabri L, Hofmann A, Jordi M, Spycher MO, Cattepoel S, Brasseit J, Panousis C, Rowe T, Branch DR, Baz Morelli A, Kaesermann F, Zuercher AW 2018 J Immunol View Researchers Basic research
Acquired factor XIII deficiency: A review Yan MTS, Rydz N, Goodyear D, Sholzberg M 2018 Transfus Apher Sci View Researchers Other
Comparative pharmacokinetics of two extended half-life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: Is there a difference? Carcao MD, Chelle P, Clarke E, Kim L, Tiseo L, Morfini M, Hossain T, Rand ML, Brown C, Edginton AN, Lillicrap D, Iorio A, Blanchette VS 2019 J Thromb Haemost View Researchers Clinical research
Barriers and enablers to source plasma donation by gay, bisexual and other men who have sex with men under revised eligibility criteria: protocol for a multiple stakeholder feasibility study Vesnaver E, Goldman M, O’Brien S, MacPherson P, Butler-Foster T, Lapierre D, Otis J, Devine DV, Germain M, Rosser A, MacDonagh R, Randall T, Osbourne-Sorrell W, Clement-Thorne B, Al-Bakri TB, Rubini KA, Hill NE, Presseau J 2020 Health Res Policy Syst View Researchers MSM research
The Missing Pieces to the Cold-Stored Platelet Puzzle Zhao H, Devine DV 2022 Int J Mol Sci View Researchers Basic research
Use of CRISPR/Cas9 gene editing to improve chimeric antigen-receptor T cell therapy: A systematic review and meta-analysis of preclinical studies Maganti HB, Kirkham AM, Bailey AJM, Shorr R, Kekre N, Pineault N, Allan DS 2022 Cytotherapy View Researchers Clinical research
The international experience of bacterial screen testing of platelet components with automated microbial detection systems: An update Kamel H, Ramirez-Arcos S, McDonald C, ISBT Transfusion-Transmitted Infectious Disease Bacterial Working Party Bacterial Subgroup 2022 Vox Sang View Researchers Benchmarking and standard setting
Modulation of Neutrophil Function by Recombinant Human IgG1 Fc Hexamer in the Endogenous K/BxN Mouse Model of Rheumatoid Arthritis Almizraq RJ, Frias Boligan K, Lewis BJB, Cen S, Whetstone H, Spirig R, Käsermann F, Campbell IK, von Gunten S, Branch DR 2023 Pharmacology View Researchers Basic research