Our Research Publications
Updated November 2023
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Title | Authors | Year | Journal | Link to Article | Intended Audience Sort descending | Purpose |
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Screening of red blood cells for extracellular vesicle content as a product quality indicator | Acker JP, Almizraq RJ, Millar D, Maurer-Spurej E | 2018 | Transfusion | View Screening of red blood cells for extracellular vesicle content as a product quality indicator | Researchers | New or improved product or process |
Anti-M (French) | Clarke G, Cote J, Lane D | 2018 | Blood.ca website | View Anti-M (French) | Researchers | Basic research |
Concentré de recherche : Dépistage d'agents pathogènes : la modélisation du risque au service de la sécurité de l'approvisionnement en sang | O'Brien S | 2019 | Blood.ca website | View Concentré de recherche : Dépistage d'agents pathogènes : la modélisation du risque au service de la sécurité de l'approvisionnement en sang | Researchers | Basic research |
Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation | Wang A, Singh S, Yu B, Bloch DB, Zapol WM, Kluger R | 2019 | Transfusion | View Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation | Researchers | Basic research |
Bacterial survival in whole blood depends on plasma sensitivity and resistance to neutrophil killing | Taha M, Kyluik-Price D, Kumaran D, Scott MD, Toyofuku W, Ramirez-Arcos S | 2019 | Transfusion | View Bacterial survival in whole blood depends on plasma sensitivity and resistance to neutrophil killing | Researchers | Basic research |
Implications of variability in cell membrane permeability for design of methods to remove glycerol from frozen-thawed erythrocytes | Lahmann JM, Sanchez CC, Benson JD, Acker JP, Higgins AZ | 2020 | Cryobiology | View Implications of variability in cell membrane permeability for design of methods to remove glycerol from frozen-thawed erythrocytes | Researchers | Basic research |
Stability of 40 cytokines/chemokines in chronically ill patients under different storage conditions | Binnington B, Sakac D, Yi Q, Tong TN, Parmar N, Duong TT, Yeung RSM, Pendergrast J, Branch DR | 2020 | Cytokine | View Stability of 40 cytokines/chemokines in chronically ill patients under different storage conditions | Researchers | Basic research |
50 years of Vox Sanguinis International Forums | Lozano M, Dunbar NM, Devine DV | 2020 | Vox Sang | View 50 years of Vox Sanguinis International Forums | Researchers | Benchmarking and standard setting |
Could antigen loss be a potential mechanism to explain antibody-mediated immune suppression? | Cruz-Leal Y, Lazarus AH | 2021 | Transfusion | View Could antigen loss be a potential mechanism to explain antibody-mediated immune suppression? | Researchers | Basic research |
Evaluating blood product quality post expiry to mitigate blood shortages during the COVID-19 pandemic in Canada | Turner TR, Olafson C, Mykhailova O, Xu A, Acker JP | 2020 | Transfusion | View Evaluating blood product quality post expiry to mitigate blood shortages during the COVID-19 pandemic in Canada | Researchers | New or improved product or process |
Industry, experts and the role of the ‘invisible college’ in the dissemination of non-invasive prenatal testing in the US | Holloway K, Miller FA, Simms N | 2021 | Soc Sci Med | View Industry, experts and the role of the ‘invisible college’ in the dissemination of non-invasive prenatal testing in the US | Researchers | Ethical, legal and social implications research |
Revisiting study design and methodology for pathogen reduced platelet transfusions: a round table discussion | Heddle NM, Cardoso M, van der Meer PF | 2020 | Transfusion | View Revisiting study design and methodology for pathogen reduced platelet transfusions: a round table discussion | Researchers | Clinical research |
Transient warming affects potency of cryopreserved cord blood units | Pasha R, Howell A, Turner TR, Halpenny M, Elmoazzen H, Acker JP, Pineault N | 2020 | Cytotherapy | View Transient warming affects potency of cryopreserved cord blood units | Researchers | New or improved product or process |
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs | Wang A, Ribeiro RVP, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell TK, Cserti-Gazdewich C, Tinckam K, Kizhakkedathu JN, West L, Keshavjee S, Withers SG, Cypel M | 2022 | Sci Transl Med | View Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs | Researchers | Clinical research |
Meta-Analysis of Risk of Vaccine-Induced Immune Thrombotic Thrombocytopenia Following ChAdOx1-S Recombinant Vaccine | Chan BT, Bobos P, Odutayo A, Pai M | 2021 | medRxiv | View Meta-Analysis of Risk of Vaccine-Induced Immune Thrombotic Thrombocytopenia Following ChAdOx1-S Recombinant Vaccine | Researchers | Clinical research |
The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients | Alshalani A, van Manen L, Boshuizen M, van Bruggen R, Acker JP, Juffermans NP | 2021 | Transfus Med Hemotherapy | View The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients | Researchers | Clinical research |
Mixing study to diagnose heparin-resistance caused by functional antithrombin deficiency | Bahabri A, Moffat KA, Carlino SA, Chan AKC, Bhatt MD | 2022 | Int J Lab Hematol | View Mixing study to diagnose heparin-resistance caused by functional antithrombin deficiency | Researchers | Basic research |
Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner | De Silva E, Devine DV, Jan E, Roskelley CD, Kim H | 2022 | Biochem J | View Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner | Researchers | Basic research |
Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned | Hefler J, Hatami S, Thiesen A, Olafson C, Durand K, Acker J, Karvellas CJ, Bigam DL, Freed DH, Shapiro AMJ | 2022 | Biomedicines | View Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned | Researchers | New or improved product or process |
An evaluation of the clinical impacts of 7-day platelets | Ning S, Gabarin N, Li N, Liu Y, Lucier K, Barty R, Acker J, Webert KE, Warkentin TE, Arnold DM, Heddle NM | 2023 | Transfusion | View An evaluation of the clinical impacts of 7-day platelets | Researchers | Clinical research |
Coagulation and complement: Key innate defense participants in a seamless web | Pryzdial ELG, Leatherdale A, Conway EM | 2022 | Front Immunol | View Coagulation and complement: Key innate defense participants in a seamless web | Researchers | Basic research |
ResearchUnit: Evaluating infusion pump safety for red blood cell transfusions | Wolfe A | 2022 | Blood.ca website | View ResearchUnit: Evaluating infusion pump safety for red blood cell transfusions | Researchers | Benchmarking and standard setting |
An analysis of the bias in red blood cell hemolysis measurement using several analytical approaches | Acker JP, Croteau IM, Yi QL | 2012 | Clin Chim Acta | View An analysis of the bias in red blood cell hemolysis measurement using several analytical approaches | Researchers | New or improved product or process |
Blood bag plasticizers influence red blood cell vesiculation rate without altering the lipid composition of the vesicles | Bicalho B, Serrano K, dos Santos Pereira A, Devine D, Acker J | 2016 | Transfus Med Hemother | View Blood bag plasticizers influence red blood cell vesiculation rate without altering the lipid composition of the vesicles | Researchers | Basic research |
Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma | Loza-Correa M, Kalab M, Yi QL, Eltringham?Smith L, Sheffield W, Ramirez-Arcos S | 2017 | Vox Sang | View Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma | Researchers | Basic research |
Different doses of prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation (Protocol) | Estcourt LJ, Stanworth S, Doree C, Trivella M, Hopewell S, Murphy MF, Tinmouth A | 2014 | Cochrane Database Syst Rev | View Different doses of prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation (Protocol) | Researchers | Clinical research |
Effect of liposome-treated red blood cells in an anemic rat model | da Silveira Cavalcante L, Feng Q, Chin-Yee I, Acker JP, Holovati JL | 2016 | J Liposome Res | View Effect of liposome-treated red blood cells in an anemic rat model | Researchers | Basic research |
Erythrocyte saturation with IgG is required for inducing antibody-mediated immune suppression and impacts both erythrocyte clearance and antigen-modulation mechanisms | Cruz-Leal Y, Marjoram D, Lazarus AH | 2018 | J Immunol | View Erythrocyte saturation with IgG is required for inducing antibody-mediated immune suppression and impacts both erythrocyte clearance and antigen-modulation mechanisms | Researchers | Basic research |
Extracellular vesicle characteristics in stored red blood cell concentrates are influenced by the method of detection | Almizraq RJ, Seghatchian J, Holovati JL, Acker JP | 2017 | Transfus Apher Sci | View Extracellular vesicle characteristics in stored red blood cell concentrates are influenced by the method of detection | Researchers | Basic research |
Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia | Lin HX, Sjaarda J, Dyck J, Stringer R, Hillis C, Harvey M, Carter R, Ainsworth P, Leber B, Pare G, Sadikovic B | 2016 | Eur J Haematol | View Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia | Researchers | Clinical research |
Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors | Chandran P, Le Y, Li Y, Sabloff M, Mehic J, Rosu-Myles M, Allan DS | 2015 | Leuk Res | View Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors | Researchers | Basic research |
Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy | Veljkovic M, Dopsaj V, Dopsaj M, Branch DR, Veljkovic N, Sakarellos-Daitsiotis MM, Veljkovic V, Glisic S, Colombatti A | 2011 | PLoS One | View Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy | Researchers | Basic research |
Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis | Hou Y, Carrim N, Wang Y, Gallant RC, Marshall A, Ni H | 2015 | J Biomed Res | View Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis | Researchers | Basic research |
Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain | Kurbegovic A, Trudel M | 2013 | Hum Mol Genet | View Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain | Researchers | Basic research |
Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study | Heddle NM, Arnold DM, Acker JP, Liu Y, Barty RL, Eikelboom JW, Webert KE, Hsia CC, O'Brien SF, Cook RJ | 2016 | Lancet Haematol | View Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study | Researchers | Clinical research |
Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers | Singh S, Dubinsky-Davidchik IS, Yang Y, Kluger R | 2015 | Org Biomol Chem | View Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers | Researchers | Basic research |
The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia | Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH | 2011 | Blood | View The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia | Researchers | Basic research |
Thrombocytopenia in the critically ill | Shehata N, Fontes ML | 2013 | Can J Anaesth | View Thrombocytopenia in the critically ill | Researchers | Other |
Transfusion-transmitted malaria: is hope around the corner? | O'Brien SF | 2016 | Lancet | View Transfusion-transmitted malaria: is hope around the corner? | Researchers | Other |
Vitamin D and kidney transplant outcomes: a protocol for a systematic review and meta-analysis | Hesketh CC, Knoll GA, Molnar AO, Tsampalieros A, Zimmerman DL | 2014 | Syst Rev | View Vitamin D and kidney transplant outcomes: a protocol for a systematic review and meta-analysis | Researchers | Clinical research |
ResearchUnit: Patient blood group impacts susceptibility to IVIg-associated hemolysis | Branch D | 2018 | Blood.ca website | View ResearchUnit: Patient blood group impacts susceptibility to IVIg-associated hemolysis | Researchers | Basic research |
A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study | Del Fiol G MM, Iorio A, Cotoi C, Haynes RB | 2018 | J Med Internet Res | View A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study | Researchers | Clinical research |
The peptidoglycan and biofilm matrix of Staphylococcus epidermidis undergo structural changes when exposed to human platelets | Loza-Correa M, Ayala JA, Perelman I, Hubbard K, Kalab M, Yi Q-L, Taha M, de Pedro MA, Ramirez-Arcos S | 2019 | PLoS One | View The peptidoglycan and biofilm matrix of Staphylococcus epidermidis undergo structural changes when exposed to human platelets | Researchers | Basic research |
Systematic reviews of guidelines and studies for single versus multiple unit transfusion strategies | Shih AW, Liu A, Elsharawi R, Crowther MA, Cook RJ, Heddle NM | 2018 | Transfusion | View Systematic reviews of guidelines and studies for single versus multiple unit transfusion strategies | Researchers | Clinical research |
Evaluating the quality of red blood cell concentrates irradiated before or after cryopreservation | Turner TR, Lautner L, Hill A, Howell A, Skeate R, Acker JP | 2020 | Transfusion | View Evaluating the quality of red blood cell concentrates irradiated before or after cryopreservation | Researchers | Basic research |
Antithrombotics from Frog Skin Secretions | Ni H | 2020 | Thromb Haemost | View Antithrombotics from Frog Skin Secretions | Researchers | Basic research |
FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity | Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K, Blumberg RS | 2020 | J Exp Med | View FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity | Researchers | Basic research |
Potentially clinically significant anti-Dib identified by monocyte monolayer assay before transfusion | Branch DR, Holton MB, Ison T, Cote J, Dube C, Lau W | 2021 | Transfusion | View Potentially clinically significant anti-Dib identified by monocyte monolayer assay before transfusion | Researchers | Basic research |
Serotonin-release assay-positive but platelet factor 4-dependent enzyme-immunoassay negative: HIT or not HIT? | Warkentin TE, Smythe MA, Ali MA, Aslam N, Sheppard JI, Smith JW, Moore JC, Arnold DM, Nazy I | 2021 | Am J Hematol | View Serotonin-release assay-positive but platelet factor 4-dependent enzyme-immunoassay negative: HIT or not HIT? | Researchers | Clinical research |
The utility of a monocyte monolayer assay in the assessment of intravenous immunoglobulin–associated hemolysis | Tong TN, Blacquiere M, Sakac D, Burke-Murphy E, Yi Q, Callum J, Cserti-Gazdewich C, Parmar N, Shehata N, Pavenski K, Lau W, Lin Y, Lieberman L, Branch DR, Pendergrast J | 2020 | Transfusion | View The utility of a monocyte monolayer assay in the assessment of intravenous immunoglobulin–associated hemolysis | Researchers | New or improved product or process |