Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
p38 mitogen-activated protein kinase regulates mitochondrial function and microvesicle release in riboflavin- and ultraviolet light–treated apheresis platelet concentrates Chen Z, Schubert P, Bakkour S, Culibrk B, Busch MP, Devine DV 2017 Transfusion View Researchers Basic research
Plasma fibronectin supports hemostasis and regulates thrombosis Wang Y, Reheman A, Spring CM, Kalantari J, Marshall AH, Wolberg AS, Gross PL, Weitz JI, Rand ML, Mosher DF, Freedman J, Ni H 2014 J Clin Invest View Researchers Basic research
Positioning new treatments in the management of immune thrombocytopenia Arnold DM 2013 Pediatr Blood Cancer View Researchers Clinical research
Riboflavin and ultraviolet illumination affects selected platelet mRNA transcript amounts differently Klein-Bosgoed C, Schubert P, Devine DV 2016 Transfusion View Researchers Basic research
Tissue factor and glycoprotein C on herpes simplex virus type 1 are protease-activated receptor 2 cofactors that enhance infection Sutherland MR, Ruf W, Pryzdial EL 2012 Blood View Researchers Basic research
Cardiac stress biomarkers after red blood cell transfusion in patients at risk for transfusion-associated circulatory overload: a prospective observational study Callum JL, Cohen R, Cressman AM, Strauss R, Armali C, Lin Y, Pendergrast J, Lieberman L, Scales DC, Skeate R, Ross H, Cserti-Gazdewich C 2018 Transfusion View Researchers Clinical research
ResearchUnit: Modeling risk to ensure safety when considering changes to blood testing O'Brien S 2019 Blood.ca website View Researchers Basic research
Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI 2018 J Thromb Haemost View Researchers Basic research
The association between platelet transfusions and mortality in patients with critical illness Ning S, Liu Y, Barty R, Cook R, Rochwerg B, Iorio A, Warkentin TE, Heddle NM, Arnold DM 2019 Transfusion View Researchers Clinical research
The impact of red blood cell manufacturing variables on bacterial growth dynamics: a pilot study Ramirez-Arcos S, Kou Y, Cayer M-P, De Grandmont M-J, Girard M, Cloutier M 2019 Vox Sang View Researchers Basic research
Overcoming the deceptively low viability of CD45+ cells in thawed cord blood unit segments Pasha R, Halpenny M, Pineault N 2019 Vox Sang View Researchers New or improved product or process
The 14-3-3ζ–c-Src–integrin-?3 complex is vital for platelet activation Shen C, Liu M, Xu R, Wang G, Li J, Chen P, Ma W, Mwangi J, Lu Q, Duan Z, Zhang Z, Dahmani FZ, Mackeigan DT, Ni H, Lai R 2020 Blood View Researchers Basic research
Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): Study protocol for an international, multicenter, randomized open-label trial Bégin P, Callum J, Heddle N, Cook R, Zeller MP, Tinmouth A, Fergusson D, Cushing MM, Glesby MJ, Chassé M, Devine DV, Robitaille N, Bazin R, Shehata N, Finzi A, McGeer A, Scales D, Schwartz L, Turgeon AF, Zarychanski R, Daneman N, Carl R, Amorim L, Gabe C, Ellis M, Jamula E, Carruthers J, Duncan J, Lucier K, Armali C, Kron A, Modi D, Auclair M-C, Avram M, Arnold DM 2021 Trials View Researchers Clinical research
Establishment of Transfusion-Relevant Bacteria Reference Strains for Red Blood Cells Prax M, Spindler-Raffel E, McDonald CP, Bearne J, Satake M, Kozakai M, Rojo J, Hanschmann K-MO, Lambrecht B, Grundmann U, O’Flaherty N, Klimek A, Bekeredjian-Ding I, Gathof BS, Störmer M, Süßner S, Renke C, Lee C-k, Knabbe C, Vollmer T, Keil SD, Shipps ME, Wagner SJ, Jentsch U, Mpumlwana X, Cloutier M, Bringmann P, Lu T, Ramirez-Arcos S, Kou Y, Krut O, ISBT Transfusion-Transmitted Infectious Diseases Working Party SoB 2020 Vox Sang View Researchers New or improved product or process
In Vitro Characterization and Metabolomic Analysis of Cold-Stored Platelets Zhao HW, Serrano K, Stefanoni D, D’Alessandro A, Devine DV 2021 J Proteome Res View Researchers Basic research
Pathogen reduction of whole blood: Supplementing fibrinogen partly corrects clot formation in a massive transfusion model Arbaeen AF, Schubert P, Sheffield WP, Devine DV 2021 Transfusion View Researchers New or improved product or process
Transient loss of membrane integrity following intracellular ice formation in dimethyl sulfoxide-treated hepatocyte and endothelial cell monolayers William N, Acker JP 2020 Cryobiology View Researchers Basic research
Heparin-Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia Antibodies: Fraternal-Not Identical-Twins Warkentin TE 2021 Thromb Haemost View Researchers Clinical research
Vaccine-induced immune thrombotic thrombocytopenia presenting with normal platelet count Page D, Zhu N, Sawler D, Sun HW, Turley E, Pai M, Wu C 2021 Res Pract Thromb Haemost View Researchers Clinical research
External qualification of the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) models for octocog alfa using real patient data Chelle P, Hajducek D, Mahdi M, Young S, Iorio A, Silvertown J, Edginton A 2021 Res Pract Thromb Haemost View Researchers New or improved product or process
In Vitro Effect of Methamphetamine on Proliferation, Differentiation and Apoptosis of Adipose Tissue Stem Cells: In vitro Effect of Methamphetamine Anari L, Mehrabani D, Nasiri M, Zare S, Jamhiri I, Acker J 2022 J Pharm Sci View Researchers Basic research
Characterization of CD41(+) cells in the lymph node Dai L, Uehara M, Li X, LaBarre BA, Banouni N, Ichimura T, Lee-Sundlov MM, Kasinath V, Sullivan JA, Ni H, Barone F, Giannini S, Bahmani B, Sage PT, Patsopoulos NA, Tsokos GC, Bromberg JS, Hoffmeister K, Jiang L, Abdi R 2022 Front Immunol View Researchers Basic research
How do we forecast tomorrow's transfusion? Applying social science approaches to meet tomorrow's transfusion needs: Blood donors and donation Haw J, Holloway K, Goldman M 2023 Transfus Clin Biol View Researchers Ethical, legal & social implications research
Antigen copy number and antibody dose can determine the outcome of erythrocyte alloimmunization inducing either antibody-mediated immune suppression or enhancement in a murine model Wabnitz H, Cruz-Leal Y, Lazarus AH 2023 Transfusion View Researchers Basic research
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects Yu X, Menard M, Seabright G, Crispin M, Lazarus AH 2015 Transfusion View Researchers Basic research
Amelioration of Murine Passive Immune Thrombocytopenia by IVIg and a Therapeutic Monoclonal CD44 Antibody Does Not Require the Myd88 Signaling Pathway Crow AR, Yu H, Han D, Lazarus AH 2013 PLoS One View Researchers Basic research
CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia Guo L, Kapur R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW 2016 Blood View Researchers Basic research
Clinical Studies of Ex Vivo Expansion to Accelerate Engraftment After Umbilical Cord Blood Transplantation: A Systematic Review Kiernan J, Damien P, Monaghan M, Shorr R, McIntyre L, Fergusson D, Tinmouth A, Allan D 2016 Transfus Med Rev View Researchers Clinical research
Engineering biomaterials surfaces to modulate the host response Yu K, Mei Y, Hadjesfandiari N, Kizhakkedathu JN 2014 Colloids Surf B Biointerfaces View Researchers Basic research
Immunogenicity of murine mPEG-red blood cells and the risk of anti-PEG antibodies in human blood donors Le Y, Toyofuku WM, Scott MD 2017 Exp Hematol View Researchers Basic research
Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution Imran ul-haq M, Lai BF, Chapanian R, Kizhakkedathu JN 2012 Biomaterials View Researchers Basic research
IVIG regulates the survival of human but not mouse neutrophils Schneider C, Wicki S, Graeter S, Timcheva TM, Keller CW, Quast I, Leontyev D, Djoumerska-Alexieva IK, Kasermann F, Jakob SM, Peyta D, Branch D, Cummings J, Kaufmann T, Simon H, Von Gunten S 2017 Sci Rep View Researchers Basic research
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Jr., Semple JW 2017 Blood Adv View Researchers Basic research
Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags Buckley K, Atkins CG, Chen D, Schulze HG, Devine DV, Blades MW, Turner RFB 2016 Analyst View Researchers New or improved product or process
Platelet MicroRNAs: An Overview Dahiya N, Sarachana T, Vu L, Becker KG, Wood WH, Zhang Y, Atreya CD 2015 Transfus Med Rev View Researchers Basic research
Preserving and using germplasm and dissociated embryonic cells for conserving Caribbean and Pacific coral Hagedorn M, Carter V, Martorana K, Paresa MK, Acker J, Baums IB, Borneman E, Brittsan M, Byers M, Henley M, Laterveer M, Leong JA, McCarthy M, Meyers S, Nelson BD, Petersen D, Tiersch T, Uribe RC, Woods E, Wildt D 2012 PLoS One View Researchers Basic research
The immune-stimulation capacity of liposome-treated red blood cells da Silveira Cavalcante L, Branch DR, Duong TT, Yeung RSM, Acker JP, Holovati JL 2017 J Liposome Res View Researchers Basic research
Utility of cross-matched platelet transfusions in patients with hypoproliferative thrombocytopenia: a systematic review Vassallo RR, Fung M, Rebulla P, Duquesnoy R, Saw CL, Slichter SJ, Tanael S, Shehata N, International Collaboration for Guideline Development Implementation Evaluation for Transfusion Therapies Collaborators 2013 Transfusion View Researchers Clinical research
Anti-M Clarke G, Cote J, Lane D 2018 Blood.ca website View Researchers Basic research
Systematic review of fondaparinux for heparin-induced thrombocytopenia: When there are no randomized controlled trials Linkins L, Hu G, Warkentin TE 2018 Res Pract Thromb Haemost View Researchers Clinical research
How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry Patriquin CJ, Kiss T, Caplan S, Chin-Yee I, Grewal K, Grossman J, Larratt L, Marceau D, Nevill T, Sutherland DR, Wells RA, Leber B 2019 Eur J Haematol View Researchers Clinical research
A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss Sheffield WP, Eltringham-Smith LJ, Bhakta V 2018 BMC Biotechnol View Researchers Basic research
Evaluating the Clinical Effect of Female Blood Donors of Child-Bearing Age on Maternal and Neonatal Outcomes: A Cohort Study Chassé M, Tinmouth A, Goldman M, O'Brien SF, Hawken S, Murphy MSQ, Walker M, Sprague AE, Wilson K, van Walraven C, Fergusson DA 2019 Transfus Med Rev View Researchers Clinical research
Isoagglutinin-reduced immunoglobulin retains efficacy in mouse models of immune thrombocytopenia and rheumatoid arthritis and is less likely to cause intravenous immunoglobulin–associated hemolysis Cen SY, Branch DR 2020 Transfusion View Researchers Basic research
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fc? receptor inhibition Norris PAA, Kaur G, Khan R, Zhu G, Ni H, Lazarus AH 2021 Blood View Researchers Basic research
Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing Tremblay T, Branch DR, Loubaki L 2020 Transfusion View Researchers New or improved product or process
Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin Eltringham-Smith LJ, Bhakta V, Sheffield WP 2021 J Biotechnol View Researchers Basic research
Five novel FY null alleles associated with typing discrepancies Vege S, Floch A, Lomas-Frances C, Clarke G, Westhoff CM 2021 Transfusion View Researchers Benchmarking and standard setting
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study Nasreen S, Calzavara AJ, Sundaram ME, MacDonald SE, Righolt CH, Pai M, Field TS, Zhou LW, Wilson SE, Kwong JC 2021 BMJ Open View Researchers Clinical research
Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity Khan H, Jain S, Gallant RC, Syed MH, Zamzam A, Al-Omran M, Rand ML, Ni H, Abdin R, Qadura M 2021 J Pers Med View Researchers New or improved product or process