Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Extending the pre-processing holding time of whole blood beyond 48h reduces coagulation FVIII activity and immunoglobulin G content of recovered plasma Sheffield WP, Bhakta V, Jenkins C 2018 Transfus Apher Sci View Researchers New or improved product or process
High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT Warkentin TE, Sheppard JI, Linkins L, Arnold DM, Nazy I 2018 Blood View Researchers New or improved product or process
Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries Iorio A, Stonebraker JS, Chambost H, Makris M, Coffin D, Herr C, Germini F, for the Data Demographics Committee of the World Federation of Hemophilia 2019 Ann Intern Med View Researchers Clinical research
Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? Levy JH, Ghadimi K, Faraoni D, van Diepen S, Levy B, Hotchkiss R, Connors JM, Iba T, Warkentin TE 2019 J Thromb Haemost View Researchers Clinical research
Portrayal of umbilical cord blood research in the North American popular press: promise or hype? Marcon AR, Allan D, Barber M, Murdosh B, Caulfield T 2020 Regen Med View Researchers Other
Current techniques and the future of lung preservation Lautner LJ, Freed DH, Nagendran J, Acker JP 2020 Cryobiology View Researchers Basic research
Extension of platelet shelf life with an improved bacterial testing algorithm Ramirez-Arcos S, Evans S, McIntyre T, Pang C, Yi Q-L, DiFranco C, Goldman M 2020 Transfusion View Researchers New or improved product or process
Screening of Feijoa (Acca Sellowiana (O. Berg) Burret) Fruit Effect on Proliferation and Apoptosis using Bone Marrow derived Stem Cells Model Rasekh H, Mahrabani D, Hosseini Farahi M, Masoumi S, Acker J 2021 Electron J Gen Med View Researchers Basic research
Using blood donors and solid organ transplant donors and recipients to estimate the seroprevalence of cytomegalovirus and Epstein–Barr virus in Canada: A cross-sectional study Mabilangan C, Burton C, O'Brien S, Plitt S, Eurich DT, Preiksaitis J 2020 JAMMI View Researchers Clinical research
Determinants of the intention to participate in a programme of plasma donation for fractionation among men who have sex with men Veillette-Bourbeau L, Otis J, Lewin A, Godin G, Germain M, Daunais-Laurin G, Lalonde F, Caruso J, Myhal G, Pronovost F 2021 Vox Sang View Researchers MSM research
Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia Shen C, Liu M, Mackeigan DT, Chen ZY, Chen P, Karakas D, Li J, Norris PAA, Li J, Deng Y, Long C, Lai R, Ni H 2021 Arch Toxicol View Researchers Basic research
Aspirin nonsensitivity in patients with vascular disease: Assessment by light transmission aggregometry (aspirin nonsensitivity in vascular patients) Khan H, Zamzam A, Gallant RC, Syed MH, Rand ML, Ni H, Forbes TL, Al-Omran M, Qadura M 2021 Res Pract Thromb Haemost View Researchers Clinical research
Resistance of SARS-CoV-2 beta and gamma variants to plasma collected from Canadian blood donors during the spring of 2020 Drews SJ, Abe KT, Hu Q, Samson R, Gingras A-C, Colwill K, Rathod B, Wang J, Fazel-Zarandi M, Yi Q-L, Robinson A, Wood H, Tuite A, Fisman D, Evans DH, Lin Y-CJ, O'Brien SF 2022 Transfusion View Researchers Clinical research
Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice Eltringham-Smith LJ, Meixner SC, Pryzdial ELG, Sheffield WP 2023 Sci Rep View Researchers Basic research
Closed system processing variables affect post-thaw quality characteristics of cryopreserved red cell concentrates Howell A, Turner TR, Hansen A, Lautner LJ, Yi Q, Acker JP 2022 Transfusion View Researchers Basic research
Development and validation of a sensitive flow cytometric method for determining CECs in RBC products Li W, Acker JP 2022 Clin Chim Acta View Researchers New or improved product or process
Minimal impact of anticoagulant on in vitro whole blood quality throughout a 35-day cold-storage regardless of leukoreduction timing Schubert P, Culibrk B, Bhakta V, Closas T, Sheffield WP, Devine DV, McTaggart K 2022 Transfusion View Researchers Basic research
Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke Zhang Z, Shen C, Fang M, Han Y, Long C, Liu W, Yang M, Liu M, Zhang D, Cao Q, Chen X, Fang Y, Lu Q, Hou Z, Li Y, Liu Z, Lei X, Ni H, Lai R 2022 Cell Mol Life Sci View Researchers Basic research
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium Jimenez-Diaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gomez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martinez MS, Miller G, Rodriguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK 2014 PNAS View Researchers Basic research
A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V 2014 J Thromb Thrombolysis View Researchers Basic research
Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness Arnold DM, Lauzier F, Rabbat C, Zytaruk N, Barlow Cash B, Clarke F, Heels-Ansdell D, Guyatt G, Walter SD, Davies A, Cook DJ, PROTECT Investigators on behalf of the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Clinical Trials Group 2013 Thromb Res View Researchers Clinical research
Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol English SW, Fergusson D, Chassé M, Turgeon A, Lauzier F, Griesdale D, Algird A, Kramer A, Tinmouth A, Lum C 2016 BMJ Open View Researchers Clinical research
Comparative characterisation of the biofilm-production abilities of Staphylococcus epidermidis isolated from human skin and platelet concentrates Taha M, Kohnen C, Mallya S, Kou Y, Zapata A, Ramirez-Arcos S 2018 J Med Microbiol View Researchers New or improved product or process
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia Li J, van der Wal DE, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B, Carrim N, Grozovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai Z-m, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM, Ni H 2015 Nat Commun View Researchers Basic research
Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol Lalu MM, Moher D, Marshall J, Fergusson D, Mei SH, Macleod M, Griffin G, Turgeon AF, Rudnicki M, Fishman J, Avey MT, Skidmore B, Grimshaw JM, Stewart DJ, Singh K, McIntyre L 2014 Syst Rev View Researchers Clinical research
Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury Cho N, Nguyen DH, Satkunendrarajah K, Branch DR, Fehlings MG 2012 J Neuroinflammation View Researchers Basic research
Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R 2018 Blood View Researchers Basic research
Improved resolution in extracellular vesicle populations using 405 instead of 488 nm side scatter McVey MJ, Spring CM, Kuebler WM 2018 J Extracell Vesicles View Researchers Basic research
Introduction to the Special Issue: Teaching Healthcare Operations Research, Part 1 Blake J 2016 INFORMS Transactions on Education View Researchers Other
Microparticle and mitochondrial release during extended storage of different types of platelet concentrates Marcoux G, Duchez A-C, Rousseau M, Levesque T, Boudreau LH, Thibault L, Boilard E 2016 Platelets View Researchers Basic research
Nanoformulated water-soluble paclitaxel to enhance drug efficacy and reduce hemolysis side effect Gu W, Chen J, Patra P, Yang X, Gu Q, Wei L, Acker J, Kong B 2017 J Biomater Appl View Researchers Basic research
p38 mitogen-activated protein kinase regulates mitochondrial function and microvesicle release in riboflavin- and ultraviolet light–treated apheresis platelet concentrates Chen Z, Schubert P, Bakkour S, Culibrk B, Busch MP, Devine DV 2017 Transfusion View Researchers Basic research
Plasma fibronectin supports hemostasis and regulates thrombosis Wang Y, Reheman A, Spring CM, Kalantari J, Marshall AH, Wolberg AS, Gross PL, Weitz JI, Rand ML, Mosher DF, Freedman J, Ni H 2014 J Clin Invest View Researchers Basic research
Positioning new treatments in the management of immune thrombocytopenia Arnold DM 2013 Pediatr Blood Cancer View Researchers Clinical research
Riboflavin and ultraviolet illumination affects selected platelet mRNA transcript amounts differently Klein-Bosgoed C, Schubert P, Devine DV 2016 Transfusion View Researchers Basic research
Tissue factor and glycoprotein C on herpes simplex virus type 1 are protease-activated receptor 2 cofactors that enhance infection Sutherland MR, Ruf W, Pryzdial EL 2012 Blood View Researchers Basic research
Cardiac stress biomarkers after red blood cell transfusion in patients at risk for transfusion-associated circulatory overload: a prospective observational study Callum JL, Cohen R, Cressman AM, Strauss R, Armali C, Lin Y, Pendergrast J, Lieberman L, Scales DC, Skeate R, Ross H, Cserti-Gazdewich C 2018 Transfusion View Researchers Clinical research
Electronic patient identification for sample labeling reduces wrong blood in tube errors Kaufman RM, Dinh A, Cohn CS, Fung MK, Gorlin J, Melanson S, Murphy MF, Ziman A, Elahie AL, Chasse D, Degree L, Dunbar NM, Dzik WH, Flanagan P, Gabert K, Ipe TS, Jackson B, Lane D, Raspollini E, Ray C, Sharon Y, Ellis M, Selleng K, Staves J, Yu P, Zeller M, Yazer M, BEST Collaborative 2018 Transfusion View Researchers Clinical research
Trends in IVIG use at a tertiary care Canadian center and impact of provincial use mitigation strategies: 10-year retrospective study with interrupted time series analysis Murphy MSQ, Tinmouth A, Goldman M, Chasse M, Colas JA, Saidenberg E, Shehata N, Fergusson D, Forster AJ, Wilson K 2019 Transfusion View Researchers Clinical research
Syndrome respiratoire aigu post-transfusionnel (TRALI) Petraszko T 2019 Blood.ca website View Researchers Clinical research
Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia Vollenberg R, Jouni R, Norris PAA, Burg-Roderfeld M, Cooper N, Rummel MJ, Bein G, Marini I, Bayat B, Burack R, Lazarus AH, Bakchoul T, Sachs UJ 2019 Haematologica View Researchers Basic research
ResearchUnit: Fighting inflammation with inflammation Lazarus A 2019 Blood.ca website View Researchers Clinical research
Treating murine inflammatory diseases with an anti-erythrocyte antibody Crow AR, Kapur R, Koernig S, Campbell IK, Jen C-C, Mott PJ, Marjoram D, Khan R, Kim M, Brasseit J, Cruz-Leal Y, Amash A, Kahlon S, Yougbare I, Ni H, Zuercher AW, Käsermann F, Semple JW, Lazarus AH 2019 Sci Transl Med View Researchers Basic research
A comparative study of platelet factor 4-enhanced platelet activation assays for the diagnosis of heparin-induced thrombocytopenia Rubino JG, Arnold DM, Warkentin TE, Smith JW, Kelton JG, Nazy I 2021 J Thromb Haemost View Researchers Basic research
Half a Century of Wilson & Jungner: Reflections on the Governance of Population Screening Sturdy S, Miller F, Hogarth S, Armstrong N, Chakraborty P, Cressman C, Dobrow M, Flitcroft K, Grossman D, Harris R, Hoebee B, Holloway K, Kinsinger L, Krag M, Löblová O, Löwy I, Mackie A, Marshall J, O'Hallahan J, Rabeneck L, Raffle A, Reid L, Shortland G, Steele R, Tarini B, Taylor-Phillips S, Towler B, van der Veen N, Zappa M 2020 Wellcome Open Res View Researchers Other
Public Goods, or Goods for the Public? The Commercialization of Academic Health Research Holloway K, Herder M 2020 Health Matters: Evidence, Critical Social Science, and Health Care in Canada View Researchers Ethical, legal and social implications research
Targeted recruitment of optimal donors for unrelated hematopoietic cell transplantation: The Stem Cell Club process Fingrut W, Messner HA, Allan D 2020 Hematol Oncol Stem Cell Ther View Researchers New or improved product or process
Differential Leukocyte MicroRNA Responses Following Pan T Cell, Allorecognition and Allosecretome-Based Therapeutic Activation Yang X, Toyofuku WM, Scott MD 2021 Arch Immunol Ther Exp View Researchers Basic research
Soy Isoflavones Inhibit Both GPIb-IX Signaling and ?IIb?3 Outside-In Signaling via 14-3-3? in Platelet Liu M, Wang G, Xu R, Shen C, Ni H, Lai R 2021 Molecules View Researchers Basic research
Degradation of red blood cell deformability during cold storage in blood bags Islamzada E, Matthews K, Lamoureux ES, Duffy SP, Scott MD, Ma H 2021 eJHaem View Researchers Basic research