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What is the utility of selecting platelets by cross-matching?

What is this research about?

Hypoproliferative thrombocytopenia (HT) occurs when the production of blood platelets by the bone marrow is reduced. HT may occur in patients with leukemia, aplastic anemia or in cancer patients after chemotherapy. In patients with HT, platelets are transfused to increase the platelet count to prevent excessive bleeding. Immune system recognition of mismatches between the platelet donor and recipient can cause ineffective responses to platelet transfusion. Cross-matching platelets is a method of selecting compatible platelets for patients with HT, in particular, in hospitals where access to large panels of HLA-typed platelet donors is limited.

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