Sex-mismatched red blood cell transfusions and mortality

What is this research about?

When a unit of red blood cells is selected for transfusion, compatibility is determined by the blood type of the donor and the recipient, but not their sex. However, observational studies that have looked at the relationship between donor characteristics and patient outcomes suggest that identifying a compatible donor may involve knowing more than just their blood type. Research findings point to donor characteristics like sex, age and parity (the number of times a woman has carried a pregnancy to a viable stage), as factors that may affect patient outcomes after blood transfusion.

This study summarized evidence from studies that examined the impact of sex-mismatched transfusions (when a patient receives a red blood cell transfusion from a donor of the opposite sex) on patient outcomes.

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