Aslam R, Freedman J, Semple JW: Murine platelets express Toll-like receptor 2: A potential regulator of innate and adaptive immunity. Platelets 15(4): 267-269, 2004.
 Aslam R, Speck ER, Kim M, Crow AR, Bang KWA, Nestel FP, Ni H, Lazarus AH, Freedman J, Semple JW. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumour necrosis factor-α production in vivo. Blood 107(2):637-641, 2006.
 Semple JW, Aslam R, Kim M, Speck ER, Freedman J. Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG opsonized platelets. Blood. 109(11):4803-4805, 2007.
 Semple JW: Platelets play a direct role in sepsis-associated endothelial cell death. ThrombHaemost 99(2), 249, 2008.
 Semple JW. Infections, Antigen Presenting Cells, T cells and Immune Tolerance: Their Role in the Pathogenesis of Immune Thrombocytopenia (ITP). HematolOncol Clinics N Amer. 23(6): 1177-1192, 2009.
 Semple JW, Freedman J: Platelets and Innate Immunity. Cell Mol Life Sci. 67(4):499–511, 2010.
 Semple JW, Italiano Jr JE, Freedman J. Platelets and the immune continuum. Nature Rev Immunol. 11(4):264-274, 2011.
 Semple JW. Platelets have a Role as Immune Cells. Vox Sang. 7:1-5, 2012.
 Thon JN, Peters CG, Machlus K, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Wagner DD, Weyrich AS, Semple JW, Flaumenhaft R, Italiano Jr. JE. T-granules in human platelets function in TLR9 organization and signaling. J Cell Biol. 198(4):561- 574, 2012.
Acknowledgements: This research received financial support from multiple sources including Canadian Blood Services Blood Research and Development Program funded by the federal (Health Canada), provincial and territorial Ministries of Health. The views expressed herein do not necessarily represent the view of the federal government.
Keywords: Platelets, immunity, TLR, bacteria.
Want to know more? Contact Dr.John Semple at email@example.com.
Platelets are Immune Cells! (PDF)
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