Blood Product Manufacturing and Quality Assessment:
Craig’s research efforts reside at the interface of development research and the manufacturing supply chain of blood components. His Medical Lab Technologist credentials, complemented by extensive work experience at Canadian Blood Services, and coupled with lean six sigma training, provides unique expertise which he applies to the development of quality control standards for blood and blood components.
Adequate quality control standards are key to ensuring a safe and efficient blood supply. As we better understand the functional and quality attributes of blood products we are able to influence more suitable and current standards along with streamlined manufacturing processes.
Craig’s group looks beyond the current quality control standards to increase our understanding of blood product function and to develop new standards. Most recently, his group did a study on red blood cell quality indicators and the impact of implementing semi-automated processes on the quality of red blood cells.
Craig’s group also provides a centralized trouble shooting support for Canadian Blood Services operations. With extensive knowledge of Canadian Blood Services’ products, the group solves product manufacturing problems and develops opportunities for improvement of blood components manufacturing, storage and shipping.
Sheffield WP, Bhakta V, Jenkins C: Stability of coagulation protein activities in single units or pools of cryoprecipitate during storage at 20-24°C for up to 24 h. Vox Sang 2015; doi: 10.1111/vox.12309 [Epub ahead of print].
Hansen AL, Kurach JD, Turner TR, Jenkins C, Busch MP, Norris PJ, Dugger J, Tomasulo PA, Devine DV, Acker JP: The effect of processing method on the in vitro characteristics of red blood cell products. Vox Sang 2015; 108:350-358
Acker JP, Hansen AL, Kurach JDR, Turner TR, Croteau I, Jenkins C: A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing. Transfusion 2014; doi:10.1111/trf.12679.
Sheffield WP, Bhakta V, Talbot K, Pryzdial ELG, Jenkins C: Quality of frozen transfusable plasma prepared from whole blood donations in Canada: An update. Transfus Apher Sci 2013; 49:440-6.
Mastronardi C, Schubert P, Levin E, Bhakta V, Yi Q-L, Hansen A, Stewart T, Jenkins C, Lefresne W, Sheffield W, Acker JP: Process improvement by eliminating mixing of whole blood units after an overnight hold prior to component production using the buffy coat method. Journal of Blood Transfusion 2013; 154838
Sheffield WP, Bhakta V, Mastronardi C, Ramirez‐Arcos S, Howe D, Jenkins C: Changes in coagulation factor activity and content of di (2‐ethylhexyl) phthalate in frozen plasma units during refrigerated storage for up to five days after thawing. Transfusion 2012; 52:493-502.