Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells Gierczak RF, Sutherland JS, Bhakta V, Toltl LJ, Liaw PC, Sheffield WP 2011 J Thromb Haemost View Researchers Basic research
The platelet "sugar high" in diabetes Ni H 2012 Blood View Researchers Other
Thrombolysis by chemically modified coagulation factor Xa Pryzdial ELG, Meixner SC, Talbot K, Eltringham-Smith LJ, Baylis JR, Lee FMH, Kastrup CJ, Sheffield WP 2016 J Thromb Haemost View Researchers Basic research
Serologic problems associated with administration of intravenous immune globulin (IVIg) Branch DR 2019 Immunohematology View Researchers Clinical research
A Retrospective Chart Review of Transfusion Practices in the Palliative Care Unit Setting Sirianni G, Perri G, Callum J, Gardner S, Berall A, Selby D 2018 Am J Hosp Palliat Care View Researchers Clinical research
Whole blood donors with antibodies Yan M 2019 Blood.ca website View Researchers Basic research
Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin alpha II beta 3 Signaling and Thrombus Growth Ya F, Xu XR, Shi Y, Gallant RC, Song F, Zuo X, Zhao Y, Tian Z, Zhang C, Xu X, Ling W, Ni H, Yang Y 2019 Mol Nutr Food Res View Researchers Basic research
Feasibility of photoacoustic imaging for the non-invasive quality management of stored blood bags Pinto RN, Hysi E, Bagga K, Sebastian JA, Douplik A, Acker JP, Kolios MC 2019 Vox Sang View Researchers New or improved product or process
Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation Iba T, Levy JH, Yamakawa K, Thachil J, Warkentin TE, Levi M, Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis 2019 J Thromb Haemost View Researchers New or improved product or process
Targeting ABL1 or ARG Tyrosine Kinases to Restrict HIV-1 Infection in Primary CD4+ T?Cells or in Humanized NSG Mice McCarthy SDS, Leontyev D, Nicoletti P, Binnington B, Kozlowski HN, Ostrowski M, Cochrane A, Branch DR, Wong RW 2019 J Acquir Immune Defic Syndr View Researchers Basic research
Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease Dubey S, Heinen S, Krantic S, McLaurin J, Branch DR, Hynynen K, Aubert I 2020 PLoS Pathog View Researchers Basic research
Proliferative and Regenerative Effect of Acetonic Extract of Feijoa sellowiana on Stem Cells Rasekh H, Hoseini Farahi M, Mehrabani D, Massoumi SJ, Ramzi M, Acker JP 2020 World J Plast Surg View Researchers Basic research
Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant Hamada M, Bhakta V, Andres SN, Sheffield WP 2021 Front Cardiovasc Med View Researchers Basic research
Estimating SARS-CoV-2 Seroprevalence in Canadian Blood Donors, April 2020 to March 2021: Improving Accuracy with Multiple Assays Tuite AR, Fisman D, Abe KT, Rathod B, Pasculescu A, Colwill K, Gingras A-C, Yi Q-L, O’Brien SF, Drews SJ, Pride DT 2022 Microbiol Spectr View Researchers Basic research
Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review Saeed S, Uzicanin S, Lewin A, Lieshout-Krikke R, Faddy H, Erikstrup C, Osiowy C, Seed CR, Steele WR, Davison K, Custer B, O'Brien SF, Assessment SR, Policy Sub-group of the Transfusion Transmitted Infectious Diseases Working Party of the International Society of Blood Transfusion 2022 Vox Sang View Researchers Basic research
Novel Mechanisms of Thrombopoietin Generation: The Essential Role of Kupffer Cells Karakas D, Li J, Ni H 2021 Blood View Researchers Basic research
Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein Greinacher A, Selleng K, Mayerle J, Palankar R, Wesche J, Reiche S, Aebischer A, Warkentin TE, Muenchhoff M, Hellmuth JC, Keppler OT, Duerschmied D, Lother A, Rieg S, Gawaz MP, Mueller KAL, Scheer CS, Napp M, Hahnenkamp K, Lucchese G, Vogelgesang A, Flöel A, Lovreglio P, Stufano A, Marschalek R, Thiele T 2021 Blood View Researchers Clinical research
Risk factors for neonatal thrombosis: A retrospective study conducted in a single Canadian intensive care unit Bhatia K, Solanki S, Paes B, Chan AKC, Bhatt MD 2022 Pediatr Blood Cancer View Researchers Clinical research
Mitapivat versus Placebo for Pyruvate Kinase Deficiency Al-Samkari H, Galactéros F, Glenthøj A, Rothman JA, Andres O, Grace RF, Morado-Arias M, Layton DM, Onodera K, Verhovsek M, Barcellini W, Chonat S, Judge MP, Zagadailov E, Xu R, Hawkins P, Beynon V, Gheuens S, van Beers EJ 2022 N Engl J Med View Researchers Clinical research
Chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential novel biomarkers of warm autoimmune hemolytic anemia Branch DR, Leger RM, Sakac d, Yi Q, Duong T, Yeung RSM, Binnington B, Bloch EM 2022 Blood Adv View Researchers Basic research
Adjudicating the Diagnosis of Immune Thrombocytopenia in a Clinical Research Study Gabe C, Mahamad S, John M, Duncan J, Kelton J, Arnold D 2023 TH Open View Researchers Clinical research
Hepatitis B Blood Donor Screening Data: An Under-Recognized Resource for Canadian Public Health Surveillance O’Brien SF, Reedman CN, Osiowy C, Bolotin S, Yi Q-L, Lourenço L, Lewin A, Binka M, Caffrey N, Drews SJ 2023 Viruses View Researchers Clinical research
Rapid potency assessment of autologous peripheral blood stem cells by intracellular flow cytometry: the PBSC-IL-3-pSTAT5 assay Simard C, Fournier D, Pineault N, Trépanier P 2022 Cytotherapy View Researchers New or improved product or process
A role for red cell clearance in antibody-mediated inhibition of erythrocyte alloimmunization? Marjoram D, Cruz-Leal Y, Bernardo L, Lazarus AH 2017 ISBT Sci Ser View Researchers Basic research
Anti-A and anti-B: what are they and where do they come from? Branch DR 2015 Transfusion View Researchers Other
Bacteria can proliferate in thawed cryoprecipitate stored at room temperature for longer than 4 h Ramirez-Arcos S, Jenkins C, Sheffield W 2017 Vox Sang View Researchers Basic research
Chapter 33: Synthesis of N-(4-Methoxybenzyl)-2-(α-d-glucopyranosyl) acetamide Roy R, Vidal S, Briard JG, Shiao TC, Ben RN 2015 Carbohydrate Chemistry: Proven Synthetic Methods, Volume 3 View Researchers Basic research
Comparison of methods for the purification of alpha-1 acid glycoprotein from human plasma McCurdy TR, Bhakta V, Eltringham-Smith LJ, Gataiance S, Fox-Robichaud AE, Sheffield WP 2011 J Biomed Biotechnol View Researchers Basic research
Dissociation of SERPINE1 mRNA from the translational repressor proteins Ago2 and TIA-1 upon platelet activation Corduan A, Ple H, Laffont B, Wallon T, Plante I, Landry P, Provost P 2015 Thromb Haemost View Researchers Basic research
Effect of texture of platelet bags on bacterial and platelet adhesion Hadjesfandiari N, Schubert P, Fallah Toosi S, Chen Z, Culibrk B, Ramirez-Arcos S, Devine DV, Brooks DE 2016 Transfusion View Researchers Basic research
Fanconi anemia proteins and their interacting partners: a molecular puzzle Kaddar T, Carreau M 2012 Anemia View Researchers Basic research
Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cells Shirvaikar N, Marquez-Curtis LA, Ratajczak MZ, Janowska-Wieczorek A 2011 Stem Cells Dev View Researchers Basic research
Liposomes alter thermal phase behavior and composition of red blood cell membranes Stoll C, Stadnick H, Kollas O, Holovati JL, Glasmacher B, Acker JP, Wolkers WF 2011 Biochim Biophys Acta View Researchers Basic research
Microfluidic analysis of red blood cell deformability as a means to assess hemin-induced oxidative stress resulting from Plasmodium falciparum intraerythrocytic parasitism Matthews K, Duffy SP, Myrand-Lapierre M-E, Ang RR, Li L, Scott MD, Ma H 2017 Integr Biol View Researchers Basic research
MT1-MMP association with membrane lipid rafts facilitates G-CSF?induced hematopoietic stem/progenitor cell mobilization Shirvaikar N, Marquez-Curtis LA, Shaw AR, Turner AR, Janowska-Wieczorek A 2010 Exp Hematol View Researchers Basic research
Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K–Akt Song F, Zhu Y, Shi Z, Tian J, Deng X, Ren J, Andrews MC, Ni H, Ling W, Yang Y 2014 Thromb Haemost View Researchers Basic research
Proteolytic modulation of factor Xa-antithrombin complex enhances fibrinolysis in plasma Talbot K, Meixner SC, Pryzdial EL 2013 Biochim Biophys Acta View Researchers Basic research
Red blood cell transfusion and mortality effect in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis protocol English SW, Chassé M, Turgeon AF, Tinmouth A, Boutin A, Pagliarello G, Fergusson D, McIntyre L 2015 Syst Rev View Researchers Clinical research
Small molecule phagocytosis inhibitors for immune cytopenias Neschadim A, Kotra LP, Branch DR 2016 Autoimmun Rev View Researchers Basic research
Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules Corcilius L, Santhakumar G, Stone RS, Capicciotti CJ, Joseph S, Matthews JM, Ben RN, Payne RJ 2013 Bioorg Med Chem View Researchers Basic research
The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game Ratajczak MZ, Kim C, Janowska-Wieczorek A, Ratajczak J 2012 ScientificWorldJournal View Researchers Basic research
The role of complement in the trafficking of hematopoietic stem/progenitor cells Janowska-Wieczorek A, Marquez-Curtis LA, Shirvaikar N, Ratajczak MZ 2012 Transfusion View Researchers Basic research
Transfusion medicine data as product Skeate RC 2013 Transfusion View Researchers Other
The association between blood donor sex and age and transfusion recipient mortality: an exploratory analysis Heddle NM, Cook RJ, Liu Y, Zeller M, Barty R, Acker JP, Eikelboom J, Arnold DM 2019 Transfusion View Researchers Clinical research
Evaluation of the functional properties of cryopreserved buffy coat-derived monocytes for monocyte monolayer assay Kipkeu BJ, Shyian ML, da Silveira Cavalcante L, Duong TT, Yeung RSM, Binnington B, Branch DR, Acker JP, Holovati JL 2018 Transfusion View Researchers Basic research
Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31) Turley E, McGowan EC, Hyland CA, Schoeman EM, Flower RL, Skoll A, Delisle MF, Nelson T, Clarke G, Au N 2018 Transfusion View Researchers Clinical research
Age-Separated RBCs Show Changes in Oxygen Carrying Capacity and Rigidity During Hypothermic Storage Mykhailova O, Li W, Acker J 2019 Probl Cryobiol Cryomed View Researchers Basic research
Decoding the metabolic landscape of pathophysiological stress-induced cell death in anucleate red blood cells Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A 2020 Blood Transfus View Researchers Basic research
Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia Li X, Sheng Z, Sun Y, Wang Y, Xu M, Zhang Z, Li H, Shao L, Zhang Y, Yu J, Ma C, Gao C, Hou M, Ni H, Peng J, Ma J, Feng Q 2020 Haematologica View Researchers Basic research
Multi-laboratory assay for harmonization of enumeration of viable CD34+ and CD45+ cells in frozen cord blood units Fournier D, Lewin A, Simard C, Trépanier P, Néron S, Ballerini L, Codinach M, Elmoazzen H, Halpenny M, Kogler G, Liedtke S, Louis I, Molluna CA, Pineault N, Prasath A, Querol S, Saccardi R, Sutherland DR, Thérien C, Urbani S 2020 Cytotherapy View Researchers Benchmarking and standard setting